ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions

Residues of the minimal sequence of G0S2 collectively contribute to ATGL inhibition while C-and N-terminal extensions promote binding to ATGL

(2022) L. Riegler-Berket et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation

(2022) Benedikt Kien et al.   JOURNAL OF LIPID RESEARCH

Structural and functional insights into ABHD5, a ligand-regulated lipase co-activator

(2022) Yan Yuan Tseng et al.   Scientific Reports

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

(2022) Rucha Patel et al.   NATURE

PNPLA1-Mediated Acylceramide Biosynthesis and Autosomal Recessive Congenital Ichthyosis

(2022) Fansi Zeng et al.   Metabolites

Chanarin‐Dorfman Syndrome: A comprehensive review

(2021) Erol Cakmak et al.   LIVER INTERNATIONAL

Non-alcoholic fatty liver disease: An overview of risk factors, pathophysiological mechanisms, diagnostic procedures, and therapeutic interventions

(2021) Samar H. Gerges et al.   LIFE SCIENCES

Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice

(2021) Ayumi Kato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Understanding FAHFAs: From structure to metabolic regulation

(2020) Kristyna Brejchova et al.   PROGRESS IN LIPID RESEARCH

Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides

(2020) Kristyna Brejchova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PNPLA3, CGI-58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice

(2019) Yang Wang et al.   HEPATOLOGY

An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis

(2019) Xiao Zhang et al.   Cells

Protein-protein interactions regulate the activity of Adipose Triglyceride Lipase in intracellular lipolysis

(2019) Natalia Kulminskaya et al.   BIOCHIMIE

ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes

(2019) Melanie Korbelius et al.   Cell Reports

Perilipin 3Deficiency Stimulates Thermogenic Beige Adipocytes ThroughPPARαActivation

(2018) Yun Kyung Lee et al.   DIABETES

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase

(2018) Krishna M. Padmanabha Das et al.   JOURNAL OF LIPID RESEARCH

Molecular mechanism of the ichthyosis pathology of Chanarin–Dorfman syndrome: Stimulation of PNPLA1-catalyzed ω-O-acylceramide production by ABHD5

(2018) Yusuke Ohno et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

ABHD5 stimulates PNPLA1-mediated ω-O-acylceramide biosynthesis essential for a functional skin permeability barrier

(2018) Benedikt Kien et al.   JOURNAL OF LIPID RESEARCH

Perilipin‐2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra‐hepatocyte actions

(2018) David J. Orlicky et al.   JOURNAL OF PHYSIOLOGY-LONDON

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

(2017) Soumik BasuRay et al.   HEPATOLOGY

PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier

(2017) Mélanie Pichery et al.   HUMAN MOLECULAR GENETICS

Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts

(2017) Linda Andersson et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides

(2017) Susanne Grond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation

(2017) Susanne Grond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

(2017) Yusuke Ohno et al.   Nature Communications

PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

(2017) Tetsuya Hirabayashi et al.   Nature Communications

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

(2017) Xiaodong Zhang et al.   eLife

Molecular Basis of ABHD5 Lipolysis Activation

(2017) Matthew A. Sanders et al.   Scientific Reports

Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets

(2017) Pengfei Zheng et al.   Scientific Reports

Identification mouse patatin-like phospholipase domain containing protein 1 as a skin-specific and membrane-associated protein

(2016) Ping-An Chang et al.   GENE

Perilipin 5 is protective in the ischemic heart

(2016) Christina Drevinge et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome

(2016) Andrew E. Libby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation

(2016) Caleb C. Lord et al.   Cell Reports

Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle

(2016) Claire Laurens et al.   Scientific Reports

Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle

(2015) Matthew A. Sanders et al.   Cell Metabolism

Muscle-Specific Deletion of Comparative Gene Identification-58 (CGI-58) Causes Muscle Steatosis but Improves Insulin Sensitivity in Male Mice

(2015) Ping Xie et al.   ENDOCRINOLOGY

Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling

(2015) Peter Hofer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids

(2015) Doris Jaeger et al.   JOURNAL OF HEPATOLOGY

Transgenic CGI-58 expression in macrophages alleviates the atherosclerotic lesion development in ApoE knockout mice

(2014) Ping Xie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Early onset of Chanarin-Dorfman syndrome with severe liver involvement in a patient with a complex rearrangement of ABHD5 promoter

(2014) Sara Missaglia et al.   BMC Medical Genetics

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

The Interplay of Protein Kinase A and Perilipin 5 Regulates Cardiac Lipolysis

(2014) Nina M. Pollak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis

(2014) Madeleine Goeritzer et al.   JOURNAL OF LIPID RESEARCH

CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization

(2014) Anita Sahu-Osen et al.   JOURNAL OF LIPID RESEARCH

Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity

(2014) Derek McMahon et al.   JOURNAL OF LIPID RESEARCH

Chanarin-Dorfman syndrome: Clinical report and novel mutation in ABHD5 gene

(2014) PM Tamhankar et al.   Journal of Postgraduate Medicine

Intestinal Cgi-58 Deficiency Reduces Postprandial Lipid Absorption

(2014) Ping Xie et al.   PLoS One

Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis

(2014) S. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice

(2014) Hongming Miao et al.   Cell Reports

Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism

(2013) Caleb C. Lord et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Formation and functions of the corneocyte lipid envelope (CLE)

(2013) Peter M. Elias et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Nonsyndromic types of ichthyoses - an update

(2013) Heiko Traupe et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Functional Cardiac Lipolysis in Mice Critically Depends on Comparative Gene Identification-58

(2013) Kathrin A. Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice

(2013) Feng Guo et al.   JOURNAL OF LIPID RESEARCH

Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction

(2013) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease

(2013) James L. McManaman et al.   JOURNAL OF LIPID RESEARCH

Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

(2013) Nina M. Pollak et al.   JOURNAL OF LIPID RESEARCH

Identification of human patatin-like phospholipase domain-containing protein 1 and a mutant in human cervical cancer HeLa cells

(2013) Ping-An Chang et al.   MOLECULAR BIOLOGY REPORTS

Acitretin-Responsive Ichthyosis in Chanarin-Dorfman Syndrome with a Novel Mutation in theABHD5/CGI-58 Gene

(2013) Rangan Srinivasaraghavan et al.   PEDIATRIC DERMATOLOGY

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

(2013) J. L. Cantley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice

(2012) Rotonya M. Carr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Subclinical myopathy in a child with neutral lipid storage disease and mutations in the PNPLA2 gene

(2012) Chiara Fiorillo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase

(2012) Manju Kumari et al.   Cell Metabolism

CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action

(2012) C. C. Lord et al.   DIABETES

Inherited ichthyoses/generalized Mendelian disorders of cornification

(2012) Matthias Schmuth et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function

(2012) Daniela Tavian et al.   HUMAN MOLECULAR GENETICS

Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases

(2012) Thomas O. Eichmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

(2012) Kenta Kuramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis

(2012) John Zhong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58

(2012) Pierre-Marie Badin et al.   JOURNAL OF LIPID RESEARCH

PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans

(2012) Anaïs Grall et al.   NATURE GENETICS

C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages

(2012) E Aflaki et al.   Cell Death & Disease

Steatohepatitis and liver cirrhosis in Chanarin-Dorfman syndrome with a new ABDH5 mutation

(2012) E. Cakmak et al.   Clinics and Research in Hepatology and Gastroenterology

An exceptional mutational event leading to Chanarin-Dorfman syndrome in a large consanguineous family

(2011) L. Samuelov et al.   BRITISH JOURNAL OF DERMATOLOGY

Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis

(2011) Elma Aflaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Loss of ceramide synthase 3 causes lethal skin barrier disruption

(2011) Richard Jennemann et al.   HUMAN MOLECULAR GENETICS

Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages

(2011) Elma Aflaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein

(2011) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Frame Shift Mutations Affecting the Carboxyl Terminus of Perilipin Increase Lipolysis by Failing to Sequester the Adipose Triglyceride Lipase (ATGL) Coactivator AB-hydrolase-containing 5 (ABHD5)

(2011) Sheetal Gandotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease

(2011) Yongcheng Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands

(2011) T. D. Russell et al.   JOURNAL OF CELL SCIENCE

Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice

(2011) Noboru Nakagawa et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

The PNPLA3 rs738409 148M/M Genotype Is a Risk Factor for Liver Cancer in Alcoholic Cirrhosis but Shows No or Weak Association in Hepatitis C Cirrhosis

(2011) Hans Dieter Nischalke et al.   PLoS One

Macrophage Adipose Triglyceride Lipase Deficiency Attenuates Atherosclerotic Lesion Development in Low-Density Lipoprotein Receptor Knockout Mice

(2010) Bart Lammers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase

(2010) Xingyuan Yang et al.   Cell Metabolism

Molecular analysis of Chanarin-Dorfman syndrome (CDS) patients: Identification of novel mutations in the ABHD5 gene

(2010) Serap Emre et al.   European Journal of Medical Genetics

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

(2010) Weiqin Chen et al.   HEPATOLOGY

PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

(2010) Elizabeth K. Speliotes et al.   HEPATOLOGY

Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase

(2010) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

(2010) Prakash G. Chandak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal Region of Comparative Gene Identification-58 (CGI-58) Is Important for Lipid Droplet Binding and Activation of Adipose Triglyceride Lipase

(2010) Astrid Gruber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral Lipid Storage Leads to Acylceramide Deficiency, Likely Contributing to the Pathogenesis of Dorfman–Chanarin Syndrome

(2010) Yoshikazu Uchida et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

(2010) J. Mark Brown et al.   JOURNAL OF LIPID RESEARCH

Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009

(2010) Vinzenz Oji et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Clinical and genetic characterization of Chanarin-Dorfman Syndrome patients: first report of large deletions in the ABHD5 gene

(2010) Chiara Redaelli et al.   Orphanet Journal of Rare Diseases

Investigation and Functional Characterization of Rare Genetic Variants in the Adipose Triglyceride Lipase in a Large Healthy Working Population

(2010) Stefan Coassin et al.   PLoS Genetics

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5

(2009) Martina Schweiger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

ABHD5/CGI-58 facilitates the assembly and secretion of apolipoprotein B lipoproteins by McA RH7777 rat hepatoma cells

(2009) Jorge M. Caviglia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

(2009) Perry E. Bickel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

(2009) S Romeo et al.   INTERNATIONAL JOURNAL OF OBESITY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Hormone-sensitive Lipase Requires Two Steps, Protein Phosphorylation and Binding to the PAT-1 Domain of Lipid Droplet Coat Proteins

(2009) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin Controls Lipolysis by Regulating the Interactions of AB-hydrolase Containing 5 (Abhd5) and Adipose Triglyceride Lipase (Atgl)

(2009) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth Retardation, Impaired Triacylglycerol Catabolism, Hepatic Steatosis, and Lethal Skin Barrier Defect in Mice Lacking Comparative Gene Identification-58 (CGI-58)

(2009) Franz P. W. Radner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase

(2009) Gabriela Montero-Moran et al.   JOURNAL OF LIPID RESEARCH

Variant in PNPLA3 is associated with alcoholic liver disease

(2009) Chao Tian et al.   NATURE GENETICS

Clinical and genetic characterization of Chanarin–Dorfman syndrome

(2008) Claudio Bruno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance

(2008) M. Bell et al.   DIABETES

Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects

(2008) T. Yanagi et al.   HUMAN MOLECULAR GENETICS

CGI-58, the Causative Gene for Chanarin-Dorfman Syndrome, Mediates Acylation of Lysophosphatidic Acid

(2008) Ananda K. Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic review series: Skin Lipids.Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism

(2008) Peter M. Elias et al.   JOURNAL OF LIPID RESEARCH

Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions

(2008) Petra C. Kienesberger et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS