The role and mechanism of histone lactylation in health and diseases

Lactylated Histone H3K18 as a Potential Biomarker for the Diagnosis and Predicting the Severity of Septic Shock

(2022) Xin Chu et al.   Frontiers in Immunology

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

(2022) Carlos Moreno-Yruela et al.   Science Advances

Lactate Activates Germline and Cleavage Embryo Genes in Mouse Embryonic Stem Cells

(2022) Qing Tian et al.   Cells

Impact of Physical Activity and Exercise on the Epigenome in Skeletal Muscle and Effects on Systemic Metabolism

(2022) Julio Plaza-Diaz et al.   Biomedicines

Chiral Posttranslational Modification to Lysine ε-Amino Groups

(2022) Carlos Moreno-Yruela et al.   ACCOUNTS OF CHEMICAL RESEARCH

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

(2022) Rui-Yuan Pan et al.   Cell Metabolism

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

(2022) Jia Xiong et al.   MOLECULAR CELL

Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress

(2022) Jingjing Lu et al.   Journal of Zhejiang University-SCIENCE B

Sirtuin 2 Regulates Protein LactoylLys Modifications

(2021) Erin Q. Jennings et al.   CHEMBIOCHEM

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

(2021) Kun Yang et al.   CELL DEATH AND DIFFERENTIATION

Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains

(2021) Xiaoxi Meng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer

(2021) Jun Jiang et al.   Frontiers in Oncology

A proteomic atlas of ligand–receptor interactions at the ovine maternal–fetal interface reveals the role of histone lactylation in uterine remodeling

(2021) Qianying Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

(2021) Wanting Yang et al.   Epigenetics & Chromatin

Protein lactylation induced by neural excitation

(2021) Hideo Hagihara et al.   Cell Reports

Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei

(2021) Naiwen Zhang et al.   Frontiers in Cell and Developmental Biology

Endothelial and T cell crosstalk: targeting metabolism as a therapeutic approach in chronic inflammation

(2020) Michelangelo Certo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lactate as a fulcrum of metabolism

(2020) George A. Brooks   Redox Biology

Harnessing inflammation resolving‐based therapeutic agents to treat pulmonary viral infections: What can the future offer to COVID‐19?

(2020) Lirlândia P. Sousa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins

(2020) Gianluca Figlia et al.   DEVELOPMENTAL CELL

Pattern recognition receptor‐mediated inflammation in diabetic vascular complications

(2020) Xu Wang et al.   MEDICINAL RESEARCH REVIEWS

Lung Myofibroblast Promote Macrophage Pro-fibrotic Activity Through Lactate-induced Histone Lactylation

(2020) Huachun Cui et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lactate Exposure Promotes Immunosuppressive Phenotypes in Innate Immune Cells

(2020) Rapeepat Sangsuwan et al.   Cellular and Molecular Bioengineering

Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea

(2020) Mingming Gao et al.   Frontiers in Microbiology

Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation

(2020) Ming Wang et al.   PHYTOMEDICINE

TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

(2020) Ricardo A. Irizarry-Caro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

(2019) Bérénice A. Benayoun et al.   GENOME RESEARCH

Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/Axl NF κB/Nrf2 axis

(2019) Dan-Qian Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microbiome–metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease

(2019) Ya-Long Feng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics

(2019) Xiucong Bao et al.   MOLECULAR CELL

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Salt, inflammation, IL-17 and hypertension

(2018) Ulrich O Wenzel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lactate metabolism: historical context, prior misinterpretations, and current understanding

(2018) Brian S. Ferguson et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Inflammation: The Common Pathway of Stress-Related Diseases

(2017) Yun-Zi Liu et al.   Frontiers in Human Neuroscience

Metabolic origins of spatial organization in the tumor microenvironment

(2017) Carlos Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate at the crossroads of metabolism, inflammation, and autoimmunity

(2016) Valentina Pucino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

Lactate is always the end product of glycolysis

(2015) Matthew J. Rogatzki et al.   Frontiers in Neuroscience

Post-Translational Modifications of Histones That Influence Nucleosome Dynamics

(2014) Gregory D. Bowman et al.   CHEMICAL REVIEWS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

(2014) Lunzhi Dai et al.   Nature Chemical Biology

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

(2014) Bryan G. Allen et al.   Redox Biology

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE