Chiral Posttranslational Modification to Lysine ε-Amino Groups

Histone H2B Deacylation Selectivity: Exploring Chromatin’s Dark Matter with an Engineered Sortase

(2022) Zhipeng A. Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

(2022) Carlos Moreno-Yruela et al.   Science Advances

The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway

(2021) He Huang et al.   Science Advances

Chemical Catalysis Intervening to Histone Epigenetics

(2021) Tamiko Nozaki et al.   ACCOUNTS OF CHEMICAL RESEARCH

Sirtuin 2 Regulates Protein LactoylLys Modifications

(2021) Erin Q. Jennings et al.   CHEMBIOCHEM

Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation

(2021) Kevin B. Koronowski et al.   Cell Reports

Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation

(2021) Sophie Trefely et al.   MOLECULAR CELL

Photo Cross‐Linking Probes Containing ϵ‐ N ‐Thioacyllysine and ϵ‐ N ‐Acyl‐(δ‐aza)lysine Residues

(2020) Michael Bæk et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chromatin as a key consumer in the metabolite economy

(2020) Katharine L. Diehl et al.   Nature Chemical Biology

Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues

(2020) Erika L. Varner et al.   Open Biology

Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea

(2020) Mingming Gao et al.   Frontiers in Microbiology

Identification of human D lactate dehydrogenase deficiency

(2019) Glen R. Monroe et al.   Nature Communications

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

(2019) Xingrun Zhang et al.   Cell Discovery

Chemoenzymatic Semisynthesis of Proteins

(2019) Robert E. Thompson et al.   CHEMICAL REVIEWS

Chemical Probes Reveal Sirt2’s New Function as a Robust “Eraser” of Lysine Lipoylation

(2019) Yusheng Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease

(2018) Elizabeth A Rowland et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

How many human proteoforms are there?

(2018) Ruedi Aebersold et al.   Nature Chemical Biology

A chemical reporter facilitates the detection and identification of lysine HMGylation on histones

(2018) Xiucong Bao et al.   Chemical Science

Lipoic acid metabolism and mitochondrial redox regulation

(2017) Ashley Solmonson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Class I Histone Deacetylases in a “Complex” Environment

(2017) Christopher J. Millard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

(2017) Martin Pannek et al.   Nature Communications

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

(2016) Andreas S. Madsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

(2016) Iacopo Galleano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Structure of p300 in complex with acyl-CoA variants

(2016) Zuzanna Kaczmarska et al.   Nature Chemical Biology

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats

(2016) Shannon L. Kesl et al.   Nutrition & Metabolism

Chemical proteomics approaches to examine novel histone posttranslational modifications

(2015) Xin Li et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

(2015) Pedro Gomes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Developing diazirine-based chemical probes to identify histone modification ‘readers’ and ‘erasers’

(2015) Tangpo Yang et al.   Chemical Science

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The glyoxalase pathway: the first hundred years… and beyond

(2013) Marta Sousa Silva et al.   BIOCHEMICAL JOURNAL

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

(2013) R. E. Moellering et al.   SCIENCE

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Human Serum Metabolome

(2011) Nikolaos Psychogios et al.   PLoS One

Crystal Structures of Human HMG-CoA Synthase Isoforms Provide Insights into Inherited Ketogenesis Disorders and Inhibitor Design

(2010) Naeem Shafqat et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology