Impact of Physical Activity and Exercise on the Epigenome in Skeletal Muscle and Effects on Systemic Metabolism

The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle

(2021) Mohd-Firdaus Maasar et al.   Frontiers in Physiology

METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels

(2021) Li-Ting Diao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise

(2021) Vandré C. Figueiredo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Short‐term running exercise alters DNA methylation patterns in neuronal nitric oxide synthase and brain‐derived neurotrophic factor genes in the mouse hippocampus and reduces anxiety‐like behaviors

(2021) Yuki Tomiga et al.   FASEB JOURNAL

Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle

(2021) Bradley A. Ruple et al.   FASEB JOURNAL

Exercise and ribosome biogenesis in skeletal muscle hypertrophy: Impact of genetic and epigenetic factors

(2021) Robert Solsona et al.   JOURNAL OF PHYSIOLOGY-LONDON

Protective role of physical activity patterns prior to COVID-19 confinement with the severity/duration of respiratory pathologies consistent with COVID-19 symptoms in Spanish populations

(2021) Pedro Ángel Latorre-Román et al.   Research in Sports Medicine

Impact of Exercise on Gut Microbiota in Obesity

(2021) Jerónimo Aragón-Vela et al.   Nutrients

Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501

(2021) Maria Goldberg et al.   Translational Psychiatry

Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health

(2021) Kristine Williams et al.   Molecular Metabolism

Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration

(2021) Shu-Juan Xie et al.   Frontiers in Cell and Developmental Biology

The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise

(2020) Ivan J. Vechetti et al.   JOURNAL OF PHYSIOLOGY-LONDON

Muscle-organ crosstalk: the emerging roles of myokines

(2020) Mai Charlotte Krogh Severinsen et al.   ENDOCRINE REVIEWS

Adaptive responses of histone modifications to resistance exercise in human skeletal muscle

(2020) Changhyun Lim et al.   PLoS One

The Interplay Between Exercise Metabolism, Epigenetics, and Skeletal Muscle Remodelling

(2020) Robert A. Seaborne et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit

(2020) Sean L. McGee et al.   Nature Reviews Endocrinology

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

(2020) Alexandra Chadt et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Sarcoplasmic Hypertrophy in Skeletal Muscle: A Scientific “Unicorn” or Resistance Training Adaptation?

(2020) Michael D. Roberts et al.   Frontiers in Physiology

The Role of Nutri(epi)genomics in Achieving the Body’s Full Potential in Physical Activity

(2020) Irene Petracci et al.   Antioxidants

DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity

(2020) D. C. Turner et al.   Scientific Reports

Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex

(2020) Hiroshi Maejima et al.   BRAIN RESEARCH

Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases

(2019) Nabil Karnib et al.   NEUROPSYCHOPHARMACOLOGY

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

(2019) Sabrina Chriett et al.   Scientific Reports

Physical Exercise and Epigenetic Modifications in Skeletal Muscle

(2019) Manuel Widmann et al.   SPORTS MEDICINE

Epigenetic changes in healthy human skeletal muscle following exercise– a systematic review

(2019) Macsue Jacques et al.   Epigenetics

Epigenetic Responses to Acute Resistance Exercise in Trained vs. Sedentary Men

(2019) James R. Bagley et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Exercise Modalities Improve Aversive Memory and Survival Rate in Aged Rats: Role of Hippocampal Epigenetic Modifications

(2019) Louisiana Carolina Ferreira de Meireles et al.   MOLECULAR NEUROBIOLOGY

The roles of DNA, RNA and histone methylation in ageing and cancer

(2019) Ewa M. Michalak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exercise enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic alterations in senescence-accelerated mice prone 8

(2019) Xiang Li et al.   NEUROSCIENCE LETTERS

Epigenetics and Exercise

(2019) Sean L. McGee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Recent Data on Cellular Component Turnover: Focus on Adaptations to Physical Exercise

(2019) Anthony MJ Sanchez et al.   Cells

Histone lactylation links metabolism and gene regulation

(2019) Luke T. Izzo et al.   NATURE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Histone Lactylation: A New Role for Glucose Metabolism

(2019) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

(2019) Harry MacKay et al.   Nature Communications

Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods

(2019) Krzysztofik et al.   International Journal of Environmental Research and Public Health

Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

(2019) Jelena Stevanović et al.   Molecular Metabolism

Hippocampal microRNA-mRNA regulatory network is affected by physical exercise

(2018) Jansen Fernandes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Exercise enhances cognitive function and neurotrophin expression in the hippocampus accompanied by changes in epigenetic programming in senescence-accelerated mice

(2018) Hiroshi Maejima et al.   NEUROSCIENCE LETTERS

Exercise and low-level GABA A receptor inhibition modulate locomotor activity and the expression of BDNF accompanied by changes in epigenetic regulation in the hippocampus

(2018) Hiroshi Maejima et al.   NEUROSCIENCE LETTERS

Exercise training alters the genomic response to acute exercise in human adipose tissue

(2018) Odile Fabre et al.   Epigenomics

Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma

(2018) Eric Hervouet et al.   Clinical Epigenetics

Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes

(2018) Natalie A. Stephens et al.   DIABETES CARE

Endocrine Crosstalk Between Skeletal Muscle and the Brain

(2018) Julien Delezie et al.   Frontiers in Neurology

The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease

(2018) Céline Tiffon   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining

(2018) R. A. Seaborne et al.   Scientific Data

Skeletal Muscle PGC1α −1 Nucleosome Position and −260 nt DNA Methylation Determine Exercise Response and Prevent Ectopic Lipid Accumulation in Men

(2017) Sudip Bajpeyi et al.   ENDOCRINOLOGY

Skeletal muscle and resistance exercise training; the role of protein synthesis in recovery and remodeling

(2017) Chris McGlory et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Role of Exercise and TFAM in Preventing Skeletal Muscle Atrophy

(2017) Nicholas T. Theilen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The RNA modification landscape in human disease

(2017) Nicky Jonkhout et al.   RNA

An Exercise‐Only Intervention in Obese Fathers Restores Glucose and Insulin Regulation in Conjunction with the Rescue of Pancreatic Islet Cell Morphology and MicroRNA Expression in Male Offspring

(2017) Nicole McPherson et al.   Nutrients

ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation

(2017) Suman Das et al.   Cell Reports

Adaptations to Endurance and Strength Training

(2017) David C. Hughes et al.   Cold Spring Harbor Perspectives in Medicine

Exercise and the Skeletal Muscle Epigenome

(2017) Sean L. McGee et al.   Cold Spring Harbor Perspectives in Medicine

Skeletal Muscle myomiR Are Differentially Expressed by Endurance Exercise Mode and Combined Essential Amino Acid and Carbohydrate Supplementation

(2017) Lee M. Margolis et al.   Frontiers in Physiology

Concurrent exercise incorporating high-intensity interval or continuous training modulates mTORC1 signaling and microRNA expression in human skeletal muscle

(2016) Jackson J. Fyfe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Treadmill exercise induces age and protocol-dependent epigenetic changes in prefrontal cortex of Wistar rats

(2016) Laura Reck Cechinel et al.   BEHAVIOURAL BRAIN RESEARCH

Physical exercise affects the epigenetic programming of rat brain and modulates the adaptive response evoked by repeated restraint stress

(2016) R.K. Kashimoto et al.   BEHAVIOURAL BRAIN RESEARCH

Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c

(2016) Jin-Sik Bae et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The impact of endurance exercise on global and AMPK gene-specific DNA methylation

(2016) Tanya S. King-Himmelreich et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Carnitine transport and fatty acid oxidation

(2016) Nicola Longo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Muscle-specific microRNAs in skeletal muscle development

(2016) Martin Horak et al.   DEVELOPMENTAL BIOLOGY

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

(2016) Dan Zhou et al.   Epigenetics

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

(2016) Krisztina Marosi et al.   JOURNAL OF NEUROCHEMISTRY

Neural Contributions to Muscle Fatigue

(2016) JANET L. TAYLOR et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Treadmill exercise induces selective changes in hippocampal histone acetylation during the aging process in rats

(2016) Louisiana Carolina Ferreira de Meireles et al.   NEUROSCIENCE LETTERS

MicroRNA expression profiling in skeletal muscle reveals different regulatory patterns in high and low responders to resistance training

(2016) Riki Ogasawara et al.   PHYSIOLOGICAL GENOMICS

How Muscle Structure and Composition Influence Meat and Flesh Quality

(2016) Anne Listrat et al.   TheScientificWorldJOURNAL

Genetic and environmental influences interact with age and sex in shaping the human methylome

(2016) Jenny van Dongen et al.   Nature Communications

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

How Muscle Structure and Composition Influence Meat and Flesh Quality

(2016) Anne Listrat et al.   Scientific World Journal

Acute stress affects the global DNA methylation profile in rat brain: Modulation by physical exercise

(2015) Gelson M. Rodrigues et al.   BEHAVIOURAL BRAIN RESEARCH

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

(2015) Nolan J. Hoffman et al.   Cell Metabolism

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction

(2015) Bethany E. Schaffer et al.   Cell Metabolism

Effects of sleeping with reduced carbohydrate availability on acute training responses

(2015) Stephen C. Lane et al.   JOURNAL OF APPLIED PHYSIOLOGY

miR-212 downregulation contributes to the protective effect of exercise against non-alcoholic fatty liver via targeting FGF-21

(2015) Junjie Xiao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

(2015) Michael J. Joyner et al.   PHYSIOLOGICAL REVIEWS

Exercise training and DNA methylation in humans

(2014) S. Voisin et al.   Acta Physiologica

Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats

(2014) Ferenc Torma et al.   BRAIN RESEARCH BULLETIN

Skeletal Muscle: A Brief Review of Structure and Function

(2014) Walter R. Frontera et al.   CALCIFIED TISSUE INTERNATIONAL

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Treadmill Exercise Alters Histone Acetyltransferases and Histone Deacetylases Activities in Frontal Cortices from Wistar Rats

(2014) Christiano Spindler et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of thePgc-1αGene and Age-Dependent Metabolic Dysfunction in the Offspring

(2014) Rhianna C. Laker et al.   DIABETES

Dynamic epigenetic responses to muscle contraction

(2014) Morten Rasmussen et al.   DRUG DISCOVERY TODAY

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training

(2014) Maléne E Lindholm et al.   Epigenetics

Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling

(2014) Donato A. Rivas et al.   FASEB JOURNAL

Spontaneous Running Wheel Improves Cognitive Functions of Mouse Associated with miRNA Expressional Alteration in Hippocampus Following Traumatic Brain Injury

(2014) Tian-hao Bao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers

(2014) Ying-li Lu et al.   Journal of Zhejiang University-SCIENCE B

The effect of exercise on epigenetic modifications of PGC1: The impact on type 2 diabetes

(2014) Júlia M. Santos et al.   MEDICAL HYPOTHESES

Histone H3 phosphorylation near the nucleosome dyad alters chromatin structure

(2014) Justin A. North et al.   NUCLEIC ACIDS RESEARCH

Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity

(2014) David S. Rowlands et al.   PHYSIOLOGICAL GENOMICS

DNA Methylation in Mammals

(2014) E. Li et al.   Cold Spring Harbor Perspectives in Biology

Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise

(2014) Marta Cosín-Tomás et al.   Frontiers in Aging Neuroscience

Mitochondrial and cellular mechanisms for managing lipid excess

(2014) Miguel A. Aon et al.   Frontiers in Physiology

Circulating micrornas as potential biomarkers of aerobic exercise capacity

(2013) Frank C. Mooren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

Epigenetic regulation of muscle phenotype and adaptation: a potential role in COPD muscle dysfunction

(2013) Esther Barreiro et al.   JOURNAL OF APPLIED PHYSIOLOGY

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training

(2013) Aaron P. Russell et al.   JOURNAL OF PHYSIOLOGY-LONDON

Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus

(2013) Gisele Agustini Lovatel et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy

(2013) Salma Awad et al.   NUCLEIC ACIDS RESEARCH

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Correction: Molecular Networks of Human Muscle Adaptation to Exercise and Age

(2013) Bethan E. Phillips et al.   PLoS Genetics

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

(2013) Tina Rönn et al.   PLoS Genetics

Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling

(2012) Zsolt Radak et al.   ANTIOXIDANTS & REDOX SIGNALING

Epigenetic Regulation and Measurement of Epigenetic Changes

(2012) K. E. Stephens et al.   Biological Research for Nursing

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

(2012) Romain Barrès et al.   Cell Metabolism

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes

(2012) M. D. Nitert et al.   DIABETES

Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: A preliminary study

(2012) Viviane Rostirola Elsner et al.   EXPERIMENTAL GERONTOLOGY

Running-induced epigenetic and gene expression changes in the adolescent brain

(2012) Jean LeBeau Abel et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Muscle protein synthesis in response to nutrition and exercise

(2012) P. J. Atherton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Run for your life

(2012) Timothy Noakes et al.   NATURE

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Epigenetics: A New Bridge between Nutrition and Health

(2012) Sang-Woon Choi et al.   Advances in Nutrition

Principles of Exercise Physiology: Responses to Acute Exercise and Long-term Adaptations to Training

(2012) Anita M. Rivera-Brown et al.   PM&R

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Epigenetic Modifications

(2011) Diane E. Handy et al.   CIRCULATION

Different Molecular and Structural Adaptations with Eccentric and Conventional Strength Training in Elderly Men and Women

(2011) Matthias Mueller et al.   GERONTOLOGY

Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men

(2010) A. C. Alibegovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation

(2010) F. Gomez-Pinilla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Intracellular Ca2+ Signaling in Skeletal Muscle

(2010) Eva R. Chin   EXERCISE AND SPORT SCIENCES REVIEWS

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

(2010) V. K. Rakyan et al.   GENOME RESEARCH

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype

(2010) Pernille Keller et al.   JOURNAL OF APPLIED PHYSIOLOGY

High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression

(2010) Peter K. Davidsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle

(2010) Søren Nielsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome

(2010) Robert S. Illingworth et al.   PLoS Genetics

Molecular responses to strength and endurance training: Are they incompatible?This paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

(2009) John A. Hawley   Applied Physiology Nutrition and Metabolism

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Exercise-induced histone modifications in human skeletal muscle

(2009) Sean L. McGee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise Improves Cognitive Responses to Psychological Stress through Enhancement of Epigenetic Mechanisms and Gene Expression in the Dentate Gyrus

(2009) Andrew Collins et al.   PLoS One

Ca2+/Calmodulin-dependent Protein Kinases

(2008) M. T. Swulius et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of theN-methyl-d-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway

(2008) Yalini Chandramohan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE