Targeting fibroblast growth factor (FGF)-inducible 14 (Fn14) for tumor therapy
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting fibroblast growth factor (FGF)-inducible 14 (Fn14) for tumor therapy
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-10-21
DOI
10.3389/fphar.2022.935086
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A Novel TNFSF-Based Signature Predicts the Prognosis and Immunosuppressive Status of Lower-Grade Glioma
- (2022) Rui Tao et al. Biomed Research International
- Elevated fibroblast growth factor‐inducible 14 expression transforms proneural‐like gliomas into more aggressive and lethal brain cancer
- (2021) Nina P. Connolly et al. GLIA
- TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease
- (2021) Adrian Cordido et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Anti-Fn14 Antibody-Conjugated Nanoparticles Display Membrane TWEAK-Like Agonism
- (2021) Ahmed Aido et al. Pharmaceutics
- Identification of a Costimulatory Molecule Gene Signature to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma
- (2021) Ling Aye et al. Frontiers in Cell and Developmental Biology
- Decreased nonspecific adhesivity, receptor-targeted therapeutic nanoparticles for primary and metastatic breast cancer
- (2020) Jimena G. Dancy et al. Science Advances
- Aging‑associated genes TNFRSF12A and CHI3L1 contribute to thyroid cancer: An evidence for the involvement of hypoxia as a driver
- (2020) Meng Lian et al. Oncology Letters
- TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity
- (2019) Juliane Medler et al. Cell Death & Disease
- Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling
- (2019) Simone Füllsack et al. Cell Death & Disease
- Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold
- (2019) David W. Vredevoogd et al. CELL
- EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis
- (2019) Lechen Li et al. ONCOGENE
- Overexpression of Fn14 in gliomas: tumor progression and poor prognosis
- (2018) Dan Tan et al. Future Oncology
- Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas
- (2018) David S. Hersh et al. JOURNAL OF NEURO-ONCOLOGY
- The TNF receptor family member Fn14 is highly expressed in recurrent glioblastoma and in GBM patient-derived xenografts with acquired temozolomide resistance
- (2018) David S Hersh et al. NEURO-ONCOLOGY
- TWEAK and RIPK1 mediate a second wave of cell death during AKI
- (2018) Diego Martin-Sanchez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Src Promotes Metastasis of Human Non-Small Cell Lung Cancer Cells through Fn14-Mediated NF-κB Signaling
- (2018) Wei Wang et al. MEDICAL SCIENCE MONITOR
- Antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class
- (2018) Hans-Georg Lerchen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- TWEAK/Fn14 Interaction Confers Aggressive Properties to Cutaneous Squamous Cell Carcinoma
- (2018) Guanglei Hu et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis
- (2018) Mohamed A. Anany et al. Cell Death & Disease
- Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor–Mediated Destruction of Intestinal Epithelial Cells
- (2017) Thomas Grabinger et al. GASTROENTEROLOGY
- Phase I Study of Enavatuzumab, a First-in-Class Humanized Monoclonal Antibody Targeting the TWEAK Receptor, in Patients with Advanced Solid Tumors
- (2017) Elaine T. Lam et al. MOLECULAR CANCER THERAPEUTICS
- Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice
- (2017) Takuhito Sezaki et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells
- (2017) Shiming Ye et al. Journal of Immunology Research
- Predictive and Prognostic Brain Metastases Assessment in Luminal Breast Cancer Patients: FN14 and GRP94 from Diagnosis to Prophylaxis
- (2017) Antonio Martínez-Aranda et al. Frontiers in Oncology
- TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice
- (2017) Valvanera Fernández-Laso et al. Scientific Reports
- Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2
- (2016) Daniela Siegmund et al. FEBS Journal
- Fn14-Fc suppresses germinal center formation and pathogenic B cells in a lupus mouse model via inhibition of the TWEAK/Fn14 Pathway
- (2016) Hong-Ki Min et al. Journal of Translational Medicine
- SGEF Is Regulated via TWEAK/Fn14/NF- B Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
- (2016) S. P. F. Ensign et al. MOLECULAR CANCER RESEARCH
- More to Life than NF-κB in TNFR1 Signaling
- (2016) Adrian T. Ting et al. TRENDS IN IMMUNOLOGY
- TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion
- (2016) Cheryl L. Armstrong et al. Oncotarget
- Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD
- (2015) M. Chopra et al. BLOOD
- Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival
- (2015) Amelia J. Johnston et al. CELL
- Principles of antibody-mediated TNF receptor activation
- (2015) H Wajant CELL DEATH AND DIFFERENTIATION
- The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics
- (2015) J G Perez et al. ONCOGENE
- FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies
- (2015) Antonio Martínez-Aranda et al. Oncotarget
- Fibroblast growth factor-inducible 14 regulates cell growth and multidrug resistance of small-cell lung cancer through the nuclear factor-κB pathway
- (2014) Xiaoping Li et al. ANTI-CANCER DRUGS
- AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
- (2014) J. Yin et al. CANCER RESEARCH
- FN14 expression correlates with MET in NSCLC and promotes MET-driven cell invasion
- (2014) Timothy G. Whitsett et al. CLINICAL & EXPERIMENTAL METASTASIS
- A Phase I Monotherapy Study of RG7212, a First-in-Class Monoclonal Antibody Targeting TWEAK Signaling in Patients with Advanced Cancers
- (2014) U. N. Lassen et al. CLINICAL CANCER RESEARCH
- The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion
- (2014) Emily Cheng et al. MOLECULAR CANCER RESEARCH
- Development of Human Serine Protease-Based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC
- (2014) H. Zhou et al. MOLECULAR CANCER THERAPEUTICS
- TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis
- (2014) I Karl et al. Cell Death & Disease
- Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR
- (2014) James W. Purcell et al. Frontiers in Immunology
- TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK
- (2014) José Antonio Carmona Arana et al. Frontiers in Immunology
- Failure of Fibrotic Liver Regeneration in Mice Is Linked to a Severe Fibrogenic Response Driven by Hepatic Progenitor Cell Activation
- (2013) Kaori Kuramitsu et al. AMERICAN JOURNAL OF PATHOLOGY
- Roles of Fibroblast Growth Factor-inducible 14 in Hepatocellular Carcinoma
- (2013) Nan Li et al. Asian Pacific Journal of Cancer Prevention
- The TWEAK-Fn14 system as a potential drug target
- (2013) Harald Wajant BRITISH JOURNAL OF PHARMACOLOGY
- Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors
- (2013) H. Zhou et al. CANCER RESEARCH
- Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation
- (2013) Harshil D. Dhruv et al. CARCINOGENESIS
- Expression of TWEAK/Fn14 in neuroblastoma: Implications in tumorigenesis
- (2013) INGVILD PETTERSEN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Fibroblast Growth Factor Inducible (Fn14)-specific Antibodies Concomitantly Display Signaling Pathway-specific Agonistic and Antagonistic Activity
- (2013) Steffen Salzmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Src Homology 3 Domain-containing Guanine Nucleotide Exchange Factor Is Overexpressed in High-grade Gliomas and Promotes Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Fibroblast Growth Factor-inducible 14-induced Cell Migration and Invasion via Tumor Necrosis Factor Receptor-associated Factor 2
- (2013) Shannon P. Fortin Ensign et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo
- (2013) Johannes Trebing et al. mAbs
- The HER2- and Heregulin β1 (HRG)–Inducible TNFR Superfamily Member Fn14 Promotes HRG-Driven Breast Cancer Cell Migration, Invasion, and MMP9 Expression
- (2013) Kaushal Asrani et al. MOLECULAR CANCER RESEARCH
- Functional Expression of TWEAK and the Receptor Fn14 in Human Malignant Ovarian Tumors: Possible Implication for Ovarian Tumor Intervention
- (2013) Liying Gu et al. PLoS One
- Elevated Expression of Fn14 in Non-Small Cell Lung Cancer Correlates with Activated EGFR and Promotes Tumor Cell Migration and Invasion
- (2012) Timothy G. Whitsett et al. AMERICAN JOURNAL OF PATHOLOGY
- The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models
- (2012) Jennifer S. Michaelson et al. CANCER BIOLOGY & THERAPY
- ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals
- (2012) K. Shimada et al. CLINICAL CANCER RESEARCH
- The ‘complexities’ of life and death: Death receptor signalling platforms
- (2012) Laura S. Dickens et al. EXPERIMENTAL CELL RESEARCH
- Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb
- (2012) Debra T. Chao et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The TWEAK Receptor Fn14 Is a Therapeutic Target in Melanoma: Immunotoxins Targeting Fn14 Receptor for Malignant Melanoma Treatment
- (2012) Hong Zhou et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Cdc42 and the Guanine Nucleotide Exchange Factors Ect2 and Trio Mediate Fn14-Induced Migration and Invasion of Glioblastoma Cells
- (2012) S. P. Fortin et al. MOLECULAR CANCER RESEARCH
- Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors
- (2012) E. Varfolomeev et al. Science Signaling
- Prognostic Significance of TWEAK Expression in Colorectal Cancer and Effect of Its Inhibition on Invasion
- (2011) Been-Ren Lin et al. ANNALS OF SURGICAL ONCOLOGY
- Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey
- (2011) B. B. Aggarwal et al. BLOOD
- Elevated fibroblast growth factor-inducible 14 expression promotes gastric cancer growth via nuclear factor-κB and is associated with poor patient outcome
- (2011) Oh-Hyung Kwon et al. CANCER LETTERS
- Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome
- (2011) Mingguo Huang et al. CARCINOGENESIS
- TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses
- (2011) Linda C. Burkly et al. IMMUNOLOGICAL REVIEWS
- Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14)
- (2011) Andrea Fick et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization
- (2011) Rebecca Feltham et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of an Fn14 agonistic antibody as an anti-tumor agent
- (2011) Jennifer S. Michaelson et al. mAbs
- Development and Characterization of a Potent Immunoconjugate Targeting the Fn14 Receptor on Solid Tumor Cells
- (2011) H. Zhou et al. MOLECULAR CANCER THERAPEUTICS
- CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration
- (2011) Juanita Lopez et al. MOLECULAR CELL
- Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination
- (2011) E. C. Dueber et al. SCIENCE
- Genetic Ablation of TWEAK Augments Regeneration and Post-Injury Growth of Skeletal Muscle in Mice
- (2010) Ashwani Mittal et al. AMERICAN JOURNAL OF PATHOLOGY
- Superior serum half life of albumin tagged TNF ligands
- (2010) Nicole Müller et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway
- (2010) Dengfeng Wang et al. CANCER LETTERS
- Antibodies to TWEAK Receptor Inhibit Human Tumor Growth through Dual Mechanisms
- (2010) P. A. Culp et al. CLINICAL CANCER RESEARCH
- The TWEAK–Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice
- (2010) Ashwani Mittal et al. JOURNAL OF CELL BIOLOGY
- Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF- B Pathway
- (2010) C. Roos et al. JOURNAL OF IMMUNOLOGY
- Asymmetric Recruitment of cIAPs by TRAF2
- (2010) Peter D. Mace et al. JOURNAL OF MOLECULAR BIOLOGY
- Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury
- (2010) Kiyohiko Hotta et al. KIDNEY INTERNATIONAL
- Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation
- (2010) Chao Zheng et al. MOLECULAR CELL
- Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer
- (2010) RYO YORIKI et al. Experimental and Therapeutic Medicine
- Fn14-Fc Fusion Protein Regulates Atherosclerosis in ApoE −/− Mice and Inhibits Macrophage Lipid Uptake In Vitro
- (2009) Kitty Schapira et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- TWEAK promotes ovarian cancer cell metastasis via NF-κB pathway activation and VEGF expression
- (2009) Lan Dai et al. CANCER LETTERS
- TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling
- (2009) A Wicovsky et al. CELL DEATH AND DIFFERENTIATION
- TNF-Like Weak Inducer of Apoptosis (TWEAK) Activates Proinflammatory Signaling Pathways and Gene Expression through the Activation of TGF- -Activated Kinase 1
- (2009) M. Kumar et al. JOURNAL OF IMMUNOLOGY
- Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Stimulation of Glioma Cell Survival Is Dependent on Akt2 Function
- (2009) S. P. Fortin et al. MOLECULAR CANCER RESEARCH
- TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
- (2008) James E. Vince et al. JOURNAL OF CELL BIOLOGY
- The Fibroblast Growth Factor-Inducible 14 Receptor Is Highly Expressed in HER2-Positive Breast Tumors and Regulates Breast Cancer Cell Invasive Capacity
- (2008) A. L. Willis et al. MOLECULAR CANCER RESEARCH
- The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting
- (2008) Jeffrey A. Winkles NATURE REVIEWS DRUG DISCOVERY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started