The TWEAK-Fn14 system as a potential drug target

Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction

(2013) Tatyana Novoyatleva et al.   BASIC RESEARCH IN CARDIOLOGY

Fibroblast Growth Factor Inducible (Fn14)-specific Antibodies Concomitantly Display Signaling Pathway-specific Agonistic and Antagonistic Activity

(2013) Steffen Salzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier

(2013) Delphine Stephan et al.   Journal of Neuroinflammation

A Polymeric Nanomedicine Diminishes Inflammatory Events in Renal Tubular Cells

(2013) Álvaro C. Ucero et al.   PLoS One

TWEAK in Inclusion-Body Myositis Muscle

(2012) Roberta Morosetti et al.   AMERICAN JOURNAL OF PATHOLOGY

Elevated Expression of Fn14 in Non-Small Cell Lung Cancer Correlates with Activated EGFR and Promotes Tumor Cell Migration and Invasion

(2012) Timothy G. Whitsett et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis

(2012) Yumin Xia et al.   CLINICAL IMMUNOLOGY

TWEAK signals through JAK–STAT to induce tumor cell apoptosis

(2012) Mark S. Chapman et al.   CYTOKINE

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Tumor necrosis factor–like weak inducer of apoptosis increases CC chemokine ligand 20 production in interleukin 1β–stimulated human gingival fibroblasts

(2012) Yoshitaka Hosokawa et al.   HUMAN IMMUNOLOGY

Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb

(2012) Debra T. Chao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism

(2012) Nadine Bakkar et al.   JOURNAL OF CELL BIOLOGY

The TWEAK Receptor Fn14 Is a Therapeutic Target in Melanoma: Immunotoxins Targeting Fn14 Receptor for Malignant Melanoma Treatment

(2012) Hong Zhou et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The cytokine tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 have a neuroprotective effect in the central nervous system

(2012) Ramiro Echeverry et al.   Journal of Neuroinflammation

The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

(2012) P. K. Paul et al.   MOLECULAR AND CELLULAR BIOLOGY

TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-кB pathway

(2012) Hui-Na Chen et al.   MOLECULAR BIOLOGY REPORTS

Cdc42 and the Guanine Nucleotide Exchange Factors Ect2 and Trio Mediate Fn14-Induced Migration and Invasion of Glioblastoma Cells

(2012) S. P. Fortin et al.   MOLECULAR CANCER RESEARCH

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

(2012) Francois Gonzalvez et al.   MOLECULAR CELL

Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling

(2012) Joshua J Sims et al.   NATURE METHODS

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

TWEAK Affects Keratinocyte G2/M Growth Arrest and Induces Apoptosis through the Translocation of the AIF Protein to the Nucleus

(2012) Sanaa Sabour Alaoui et al.   PLoS One

Inflammatory Cytokines and Survival Factors from Serum Modulate Tweak-Induced Apoptosis in PC-3 Prostate Cancer Cells

(2012) Ana Belen Sanz et al.   PLoS One

TWEAK and cIAP1 Regulate Myoblast Fusion Through the Noncanonical NF- B Signaling Pathway

(2012) E. K. Enwere et al.   Science Signaling

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

Prognostic Significance of TWEAK Expression in Colorectal Cancer and Effect of Its Inhibition on Invasion

(2011) Been-Ren Lin et al.   ANNALS OF SURGICAL ONCOLOGY

Elevated fibroblast growth factor-inducible 14 expression promotes gastric cancer growth via nuclear factor-κB and is associated with poor patient outcome

(2011) Oh-Hyung Kwon et al.   CANCER LETTERS

Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome

(2011) Mingguo Huang et al.   CARCINOGENESIS

Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes

(2011) Jiro Yamana et al.   CELLULAR IMMUNOLOGY

Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice—A Pathway Associated With Ulcerative Colitis

(2011) Rei Kawashima et al.   GASTROENTEROLOGY

TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses

(2011) Linda C. Burkly et al.   IMMUNOLOGICAL REVIEWS

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Mediates p38 Mitogen-Activated Protein Kinase Activation and Signal Transduction in Peripheral Blood Mononuclear Cells from Patients with Lupus Nephritis

(2011) Liu Zhi-Chun et al.   INFLAMMATION

Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14)

(2011) Andrea Fick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

(2011) Rebecca Feltham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlations of Urinary Biomarkers, TNF-Like Weak Inducer of Apoptosis (TWEAK), Osteoprotegerin (OPG), Monocyte Chemoattractant Protein-1 (MCP-1), and IL-8 with Lupus Nephritis

(2011) Amal El-shehaby et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Development of an Fn14 agonistic antibody as an anti-tumor agent

(2011) Jennifer S. Michaelson et al.   mAbs

Development and Characterization of a Potent Immunoconjugate Targeting the Fn14 Receptor on Solid Tumor Cells

(2011) H. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Soluble Tumor Necrosis Factor-like Weak Inducer of Apoptosis Plasma Levels as a Novel Biomarker of Endothelial Function in Prevalent Orthotopic Heart Transplant Recipients

(2011) P. Przybylowski et al.   TRANSPLANTATION PROCEEDINGS

Genetic Ablation of TWEAK Augments Regeneration and Post-Injury Growth of Skeletal Muscle in Mice

(2010) Ashwani Mittal et al.   AMERICAN JOURNAL OF PATHOLOGY

Peripheral Artery Disease Is Associated With a High CD163/TWEAK Plasma Ratio

(2010) Juan A. Moreno et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differences in the predictive value of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in advanced ischemic and non-ischemic heart failure

(2010) Bernhard Richter et al.   ATHEROSCLEROSIS

Soluble TWEAK is markedly upregulated in patients with ST-elevation myocardial infarction and related to an adverse short-term outcome

(2010) Emmanuel Chorianopoulos et al.   ATHEROSCLEROSIS

Superior serum half life of albumin tagged TNF ligands

(2010) Nicole Müller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antibodies to TWEAK Receptor Inhibit Human Tumor Growth through Dual Mechanisms

(2010) P. A. Culp et al.   CLINICAL CANCER RESEARCH

The TWEAK–Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice

(2010) Ashwani Mittal et al.   JOURNAL OF CELL BIOLOGY

The Interaction between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and its Receptor Fibroblast Growth Factor-Inducible 14 Promotes the Recruitment of Neutrophils into the Ischemic Brain

(2010) Woldeab B Haile et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF- B Pathway

(2010) C. Roos et al.   JOURNAL OF IMMUNOLOGY

Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury

(2010) Kiyohiko Hotta et al.   KIDNEY INTERNATIONAL

Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

(2010) Chao Zheng et al.   MOLECULAR CELL

Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death

(2010) W.B. Haile et al.   NEUROSCIENCE

TWEAK Activates the Non-Canonical NFκB Pathway in Murine Renal Tubular Cells: Modulation of CCL21

(2010) Ana B. Sanz et al.   PLoS One

Fn14-TRAIL, a Chimeric Intercellular Signal Exchanger, Attenuates Experimental Autoimmune Encephalomyelitis

(2009) Marjaneh Razmara et al.   AMERICAN JOURNAL OF PATHOLOGY

Fn14-Fc Fusion Protein Regulates Atherosclerosis in ApoE −/− Mice and Inhibits Macrophage Lipid Uptake In Vitro

(2009) Kitty Schapira et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) Enhances Vascular and Renal Damage Induced by Hyperlipidemic Diet in ApoE-Knockout Mice

(2009) Begoña Muñoz-García et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK

(2009) Emmanuel Chorianopoulos et al.   BASIC RESEARCH IN CARDIOLOGY

TWEAK promotes ovarian cancer cell metastasis via NF-κB pathway activation and VEGF expression

(2009) Lan Dai et al.   CANCER LETTERS

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

(2009) A Wicovsky et al.   CELL DEATH AND DIFFERENTIATION

A Novel Role for Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) in the Development of Cardiac Dysfunction and Failure

(2009) Mohit Jain et al.   CIRCULATION

TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells

(2009) Hua-Xin Gao et al.   CYTOKINE

Decreased soluble TWEAK levels predict an adverse prognosis in patients with chronic stable heart failure

(2009) Emmanuel Chorianopoulos et al.   EUROPEAN JOURNAL OF HEART FAILURE

Expression and function of fibroblast growth factor-inducible 14 in human corneal myofibroblasts

(2009) Nobuyuki Ebihara et al.   EXPERIMENTAL EYE RESEARCH

Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia

(2009) Ana B. Sanz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TNF-Like Weak Inducer of Apoptosis (TWEAK) Activates Proinflammatory Signaling Pathways and Gene Expression through the Activation of TGF- -Activated Kinase 1

(2009) M. Kumar et al.   JOURNAL OF IMMUNOLOGY

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Stimulation of Glioma Cell Survival Is Dependent on Akt2 Function

(2009) S. P. Fortin et al.   MOLECULAR CANCER RESEARCH

Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study

(2009) Noa Schwartz et al.   ARTHRITIS RESEARCH & THERAPY

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Attenuates the Action of Insulin in Hepatocytes

(2008) Feng Feng et al.   ENDOCRINOLOGY

TWEAK/Fn14 Pathway: A Nonredundant Role in Intestinal Damage in Mice Through a TWEAK/Intestinal Epithelial Cell Axis

(2008) Taeko Dohi et al.   GASTROENTEROLOGY

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis

(2008) Nadine Bakkar et al.   JOURNAL OF CELL BIOLOGY

TWEAK is expressed at the cell surface of monocytes during multiple sclerosis

(2008) S. Desplat-Jego et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model

(2008) Heather A. Iocca et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression of TWEAK and Its Receptor Fn14 in the Multiple Sclerosis Brain: Implications for Inflammatory Tissue Injury

(2008) Barbara Serafini et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation

(2008) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke

(2008) Ioana Inta et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Fibroblast Growth Factor-Inducible 14 Receptor Is Highly Expressed in HER2-Positive Breast Tumors and Regulates Breast Cancer Cell Invasive Capacity

(2008) A. L. Willis et al.   MOLECULAR CANCER RESEARCH

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

(2008) Jeffrey A. Winkles   NATURE REVIEWS DRUG DISCOVERY

Relationship of serum TWEAK level to cytokine level, disease activity, and response to anti‐TNF treatment in patients with rheumatoid arthritis

(2008) M‐C. Park et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY