Principles of antibody-mediated TNF receptor activation

The tetravalent anti-DR5 antibody without cross-linking direct induces apoptosis of cancer cells

(2015) Fengtao Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

(2015) Ann L. White et al.   CANCER CELL

Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor

(2015) Kyriakos P. Papadopoulos et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding

(2015) Jinghua Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles and mechanisms of CD95 activation

(2014) Harald Wajant   BIOLOGICAL CHEMISTRY

Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity

(2014) Jonathan D. Graves et al.   CANCER CELL

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy

(2014) Yannick Bulliard et al.   IMMUNOLOGY AND CELL BIOLOGY

Dominant Negative Effects of Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL) Receptor 4 on TRAIL Receptor 1 Signaling by Formation of Heteromeric Complexes

(2014) Simon Neumann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies

(2014) Shravan Madireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fcγ Receptor Dependency of Agonistic CD40 Antibody in Lymphoma Therapy Can Be Overcome through Antibody Multimerization

(2014) Ann L. White et al.   JOURNAL OF IMMUNOLOGY

Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction

(2014) Heather A Huet et al.   mAbs

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells

(2014) M H Tuthill et al.   ONCOGENE

HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity

(2014) Saravana Kanagavelu et al.   PLoS One

Mechanistic Basis for Functional Promiscuity in the TNF and TNF Receptor Superfamilies: Structure of the LIGHT:DcR3 Assembly

(2014) Weifeng Liu et al.   STRUCTURE

Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR

(2014) James W. Purcell et al.   Frontiers in Immunology

TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK

(2014) José Antonio Carmona Arana et al.   Frontiers in Immunology

Structure of the extracellular domains of human andXenopusFn14: implications in the evolution of TWEAK and Fn14 interactions

(2013) Maria Pellegrini et al.   FEBS Journal

Safety, pharmacokinetics, and pharmacodynamics of the DR5 antibody LBY135 alone and in combination with capecitabine in patients with advanced solid tumors

(2013) Sunil Sharma et al.   INVESTIGATIONAL NEW DRUGS

Fibroblast Growth Factor Inducible (Fn14)-specific Antibodies Concomitantly Display Signaling Pathway-specific Agonistic and Antagonistic Activity

(2013) Steffen Salzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

(2013) Yannick Bulliard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo

(2013) Johannes Trebing et al.   mAbs

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

(2013) Omid Vafa et al.   METHODS

Tetravalent Antibody-scTRAIL Fusion Proteins with Improved Properties

(2013) O. Seifert et al.   MOLECULAR CANCER THERAPEUTICS

APG350 Induces Superior Clustering of TRAIL Receptors and Shows Therapeutic Antitumor Efficacy Independent of Cross-Linking via Fc  Receptors

(2013) C. Gieffers et al.   MOLECULAR CANCER THERAPEUTICS

Dimerization of LT R by LT 1 2 is necessary and sufficient for signal transduction

(2013) J. Sudhamsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antitumor activities of agonistic anti-TNFR antibodies require differential Fc RIIB coengagement in vivo

(2013) F. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD95 in cancer: tool or target?

(2013) Ana Martin-Villalba et al.   TRENDS IN MOLECULAR MEDICINE

S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS

(2012) Heng Ru et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Properties of mouse and human IgG receptors and their contribution to disease models

(2012) P. Bruhns   BLOOD

Signaling Active CD95 Receptor Molecules Trigger Co-translocation of Inactive CD95 Molecules into Lipid Rafts

(2012) Isabell Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin

(2012) X. Luan et al.   JOURNAL OF IMMUNOLOGY

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc  receptor engagement

(2012) F. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

(2012) Christopher A. Nelson et al.   STRUCTURE

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells

(2011) Nicholas S. Wilson et al.   CANCER CELL

Engineering death receptor ligands for cancer therapy

(2011) Harald Wajant et al.   CANCER LETTERS

Antibody-based fusion proteins to target death receptors in cancer

(2011) Marco de Bruyn et al.   CANCER LETTERS

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

(2011) Tsunehiro Mizushima et al.   GENES TO CELLS

Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14)

(2011) Andrea Fick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystallographic and Mutational Analysis of the CD40-CD154 Complex and Its Implications for Receptor Activation

(2011) Hyun-Jung An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

(2011) Rebecca Feltham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

(2011) P. A. Ramsland et al.   JOURNAL OF IMMUNOLOGY

Interaction with Fc RIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody

(2011) A. L. White et al.   JOURNAL OF IMMUNOLOGY

The Crystal Structure of Death Receptor 6 (DR6): A Potential Receptor of the Amyloid Precursor Protein (APP)

(2011) Miriam Kuester et al.   JOURNAL OF MOLECULAR BIOLOGY

Development of an Fn14 agonistic antibody as an anti-tumor agent

(2011) Jennifer S. Michaelson et al.   mAbs

Expression and Purification of a Natural N-Terminal Pre-ligand Assembly Domain of Tumor Necrosis Factor Receptor 1 (TNFR1 PLAD) and Preliminary Activity Determination

(2011) Jin Cao et al.   PROTEIN JOURNAL

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE

Decoy Strategies: The Structure of TL1A:DcR3 Complex

(2011) Chenyang Zhan et al.   STRUCTURE

Soluble multi-trimeric TNF superfamily ligand adjuvants enhance immune responses to a HIV-1 Gag DNA vaccine

(2011) Saravana K. Kanagavelu et al.   VACCINE

LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts

(2010) Jing Li et al.   DRUG DEVELOPMENT RESEARCH

Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF- B Pathway

(2010) C. Roos et al.   JOURNAL OF IMMUNOLOGY

Structural and Functional Insights of RANKL-RANK Interaction and Signaling

(2010) C. Liu et al.   JOURNAL OF IMMUNOLOGY

Asymmetric Recruitment of cIAPs by TRAF2

(2010) Peter D. Mace et al.   JOURNAL OF MOLECULAR BIOLOGY

Dimers and multimers of monoclonal IgG1 exhibit higher in vitro binding affinities to Fcγ receptors

(2010) Yin Luo et al.   mAbs

Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

(2010) Chao Zheng et al.   MOLECULAR CELL

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

(2010) Yanli Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis

(2010) H. M. Ta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily

(2010) Fahu He et al.   PROTEIN SCIENCE

Solution of the Structure of the TNF-TNFR2 Complex

(2010) Y. Mukai et al.   Science Signaling

Solution NMR Investigation of the CD95/FADD Homotypic Death Domain Complex Suggests Lack of Engagement of the CD95 C Terminus

(2010) Diego Esposito et al.   STRUCTURE

1.8 Å structure of murine GITR ligand dimer expressed inDrosophila melanogasterS2 cells

(2009) Kausik Chattopadhyay et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biochemical and Structural Characterization of the Human TL1A Ectodomain,

(2009) Chenyang Zhan et al.   BIOCHEMISTRY

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

(2009) A Wicovsky et al.   CELL DEATH AND DIFFERENTIATION

Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways

(2009) Daniela Berg et al.   FEBS Journal

The Structure of the Trimer of Human 4-1BB Ligand Is Unique among Members of the Tumor Necrosis Factor Superfamily

(2009) Eun-Young Won et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Activity of Ectodysplasin A Is Conditioned by Its Collagen and Heparan Sulfate Proteoglycan-binding Domains

(2009) Lee Kim Swee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

(2009) A. Wyzgol et al.   JOURNAL OF IMMUNOLOGY

Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin

(2009) Dan Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

(2009) Fiona L. Scott et al.   NATURE

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

(2009) Lorraine A. O’ Reilly et al.   NATURE

A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes

(2008) A. Yada et al.   ANNALS OF ONCOLOGY

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization

(2008) Nicole Müller et al.   FEBS Journal

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

(2008) K. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for ligand-mediated mouse GITR activation

(2008) Z. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily

(2008) K. Chattopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA