Cerebral edema after ischemic stroke: Pathophysiology and underlying mechanisms

A Fluorogenic ONOO–-Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage

(2022) Linfeng Xing et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Post-stroke Impairment of the Blood–Brain Barrier and Perifocal Vasogenic Edema Is Alleviated by Endovascular Mesenchymal Stem Cell Administration: Modulation of the PKCδ/MMP9/AQP4-Mediated Pathway

(2022) Aishika Datta et al.   MOLECULAR NEUROBIOLOGY

Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era

(2022) Marc Fisher et al.   Nature Reviews Neurology

Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice

(2022) Guo-Yuan Yang et al.   Neural Regeneration Research

Teriparatide induces angiogenesis in ischemic cerebral infarction zones of rats through AC/PKA signaling and reduces ischemia-reperfusion injury

(2022) Moliang Xiong et al.   BIOMEDICINE & PHARMACOTHERAPY

Review of net water uptake in the management of acute ischemic stroke

(2022) XiaoQing Cheng et al.   EUROPEAN RADIOLOGY

Roles of Nitric Oxide in Brain Ischemia and Reperfusion

(2022) Yijie Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Correlation Between Computed Tomography-Based Tissue Net Water Uptake and Volumetric Measures of Cerebral Edema After Reperfusion Therapy

(2022) Felix C. Ng et al.   STROKE

Automated Measurement of Net Water Uptake From Baseline and Follow-Up CTs in Patients With Large Vessel Occlusion Stroke

(2022) Atul Kumar et al.   Frontiers in Neurology

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

(2021) Salim S. Virani et al.   CIRCULATION

Favorable Venous Outflow Profiles Correlate With Favorable Tissue-Level Collaterals and Clinical Outcome

(2021) Tobias D. Faizy et al.   STROKE

Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review

(2021) Yi Yao et al.   Frontiers in Aging Neuroscience

Association between pre-treatment perfusion profile and cerebral edema after reperfusion therapies in ischemic stroke

(2021) Felix C Ng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Molecular mechanisms of brain water transport

(2021) Nanna MacAulay   NATURE REVIEWS NEUROSCIENCE

Association of Venous Outflow Profiles and Successful Vessel Reperfusion After Thrombectomy

(2021) Tobias Djamsched Faizy et al.   NEUROLOGY

Venous Outflow Profiles Are Linked to Cerebral Edema Formation at Noncontrast Head CT after Treatment in Acute Ischemic Stroke Regardless of Collateral Vessel Status at CT Angiography

(2021) Tobias D. Faizy et al.   RADIOLOGY

The role of glymphatic system in the cerebral edema formation after ischemic stroke

(2021) Caihong Ji et al.   EXPERIMENTAL NEUROLOGY

Carnosine Protects against Cerebral Ischemic Injury by Inhibiting Matrix-Metalloproteinases

(2021) Eun-Hye Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of the noninvasive imaging techniques in monitoring and understanding the evolution of brain edema

(2021) Andre Obenaus et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Midline Shift Greater than 3 mm Independently Predicts Outcome After Ischemic Stroke

(2021) Morgan E. McKeown et al.   Neurocritical Care

Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis

(2021) Felix C. Ng et al.   STROKE

Cerebral Edema Formation After Stroke: Emphasis on Blood–Brain Barrier and the Lymphatic Drainage System of the Brain

(2021) Sichao Chen et al.   Frontiers in Cellular Neuroscience

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?

(2021) Yan-mei Qiu et al.   Frontiers in Immunology

TNF-α Receptor Inhibitor Alleviates Metabolic and Inflammatory Changes in a Rat Model of Ischemic Stroke

(2021) Shih-Yi Lin et al.   Antioxidants

Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies

(2021) Anamaria Jurcau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review

(2021) Ruchira M. Jha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphodiesterase 10A Is a Critical Target for Neuroprotection in a Mouse Model of Ischemic Stroke

(2021) Mustafa C. Beker et al.   MOLECULAR NEUROBIOLOGY

The short form of the SUR1 and its functional implications in the damaged brain

(2021) Penélope Aguilera et al.   Neural Regeneration Research

Microvascular Dysfunction in Blood-Brain Barrier Disruption and Hypoperfusion Within the Infarct Posttreatment Are Associated With Cerebral Edema

(2021) Felix C. Ng et al.   STROKE

NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood–brain barrier integrity in murine stroke

(2021) Maximilian Bellut et al.   Cell Death & Disease

Adjunctive cytoprotective therapies in acute ischemic stroke: a systematic review

(2021) I. A. Mulder et al.   Fluids and Barriers of the CNS

Systemic inflammation status at admission affects the outcome of intracerebral hemorrhage by increasing perihematomal edema but not the hematoma growth

(2020) Sérgio Fonseca et al.   ACTA NEUROLOGICA BELGICA

Emerging Pharmacological Treatments for Cerebral Edema: Evidence from Clinical Studies

(2020) Jesse A. Stokum et al.   Annual Review of Pharmacology and Toxicology

Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels After Focal Cerebral Ischemia in Rats

(2020) Jinqiao Wang et al.   Dose-Response

Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins

(2020) Lars Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a

(2020) Jinwei Zhang et al.   Nature Communications

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

(2020) Philip Kitchen et al.   CELL

Targeting Myeloid-Specific Integrin α9β1 Improves Short and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis And Inflammation

(2020) Nirav Dhanesha et al.   CIRCULATION RESEARCH

microRNA-1906 protects cerebral ischemic injury through activating Janus kinase 2/signal transducer and activator of transcription 3 pathway in rats

(2020) Xiunan Yu et al.   NEUROREPORT

Neurovascular Unit Dysfunction and Neurodegenerative Disorders

(2020) Xing Yu et al.   Frontiers in Neuroscience

Resveratrol reduces cerebral edema through inhibition of de novo SUR1 expression induced after focal ischemia

(2020) Iván Alquisiras-Burgos et al.   EXPERIMENTAL NEUROLOGY

Silencing matrix metalloproteinase 9 exerts a protective effect on astrocytes after oxygen-glucose deprivation and is correlated with suppression of aquaporin-4

(2020) Siyi Li et al.   NEUROSCIENCE LETTERS

Matrix Metalloproteinase-9 Relationship With Infarct Growth and Hemorrhagic Transformation in the Era of Thrombectomy

(2020) Laura Mechtouff et al.   Frontiers in Neurology

Association of Matrix Metalloproteinase 9 and Cellular Fibronectin and Outcome in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

(2020) Lu Wang et al.   Frontiers in Neurology

Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery

(2020) Sara Bernardo-Castro et al.   Frontiers in Neurology

Timing of Decompressive Craniectomy for Ischemic Stroke and Traumatic Brain Injury: A Review

(2019) Aatman Shah et al.   Frontiers in Neurology

Effect of intravenous injection of antagomiR-1 on brain ischemia

(2019) Anis Talebi et al.   MOLECULAR BIOLOGY REPORTS

MicroRNA-132 attenuates cerebral injury by protecting blood-brain-barrier in MCAO mice

(2019) Xiaokun Zuo et al.   EXPERIMENTAL NEUROLOGY

Exploratory Analysis of Oral Glibenclamide in Acute Ischemic Stroke

(2019) Kaibin Huang et al.   ACTA NEUROLOGICA SCANDINAVICA

Ischemic lesion growth in acute stroke: Water uptake quantification distinguishes between edema and tissue infarct

(2019) Gabriel Broocks et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypertonic saline downregulates endothelial cell-derived VEGF expression and reduces blood-brain barrier permeability induced by cerebral ischaemia via the VEGFR2/eNOS pathway

(2019) Qiaosheng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Calcitriol protects the Blood-Brain Barrier integrity against ischemic stroke and reduces vasogenic brain edema via antioxidant and antiapoptotic actions in rats

(2019) Nooshin Sadeghian et al.   BRAIN RESEARCH BULLETIN

The Medical Management of Cerebral Edema: Past, Present, and Future Therapies

(2019) Michael R. Halstead et al.   Neurotherapeutics

Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction

(2019) Pongpat Vorasayan et al.   STROKE

Cerebral Edema Associated With Large Hemispheric Infarction

(2019) David S. Liebeskind et al.   STROKE

Protective effect of edaravone on blood-brain barrier by affecting NRF-2/HO-1 signaling pathway

(2019) Jing Liu et al.   Experimental and Therapeutic Medicine

BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema

(2019) Melissa Pergakis et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke

(2019) Bo Chen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke

(2019) Alicia García-Culebras et al.   STROKE

N2 neutrophils may participate in spontaneous recovery after transient cerebral ischemia by inhibiting ischemic neuron injury in rats

(2019) Ying Hou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury: a literature review

(2019) Zili Feng et al.   MOLECULAR MEDICINE

Glimepiride and glibenclamide have comparable efficacy in treating acute ischemic stroke in mice

(2019) Xiaoqiang Wang et al.   NEUROPHARMACOLOGY

Selective mGluR1 Negative Allosteric Modulator Reduces Blood–Brain Barrier Permeability and Cerebral Edema After Experimental Subarachnoid Hemorrhage

(2019) Cheng Zhang et al.   Translational Stroke Research

Effect of Combination Therapy with Neuroprotective and Vasoprotective Agents on Cerebral Ischemia

(2018) Jiping Yang et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Cerebrolysin and Aquaporin 4 Inhibition Improve Pathological and Motor Recovery after Ischemic Stroke

(2018) Bogdan Catalin et al.   CNS & Neurological Disorders-Drug Targets

Sema4D/PlexinB1 inhibition ameliorates blood–brain barrier damage and improves outcome after stroke in rats

(2018) Yi-Fan Zhou et al.   FASEB JOURNAL

The Immune System and Stroke: From Current Targets to Future Therapy

(2018) Kyle Malone et al.   IMMUNOLOGY AND CELL BIOLOGY

Comparative Analysis of Markers of Mass Effect after Ischemic Stroke

(2018) Ann-Christin Ostwaldt et al.   JOURNAL OF NEUROIMAGING

Mannitol in Critical Care and Surgery Over 50+ Years

(2018) Weiliang Zhang et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

(2018) Ming-Shuo Sun et al.   Oxidative Medicine and Cellular Longevity

Impact of microRNAs on ischemic stroke: From pre- to post-disease

(2018) Guangwen Li et al.   PROGRESS IN NEUROBIOLOGY

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Long-Term Outcomes in Patients Aged ≤70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction

(2018) Kevin N. Sheth et al.   STROKE

Non-Invasive Multimodality Imaging Directly Shows TRPM4 Inhibition Ameliorates Stroke Reperfusion Injury

(2018) Bo Chen et al.   Translational Stroke Research

Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke

(2018) W. Taylor Kimberly et al.   JAMA Neurology

Thrombopoietin could protect cerebral tissue against ischemia-reperfusion injury by suppressing NF-κB and MMP-9 expression in rats

(2018) Wenjuan Wu et al.   International Journal of Medical Sciences

SUR1, TRPM4 and KIR6.2 – role in hemorrhagic progression of contusion

(2018) Volodymyr Gerzanich et al.   JOURNAL OF NEUROTRAUMA

Pathophysiology and treatment of cerebral edema in traumatic brain injury

(2018) Ruchira M. Jha et al.   NEUROPHARMACOLOGY

Futile Recanalization With Poor Clinical Outcome Is Associated With Increased Edema Volume After Ischemic Stroke

(2018) Jawed Nawabi et al.   INVESTIGATIVE RADIOLOGY

Aquaporins in brain edema

(2018) Tifenn Clément et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial

(2018) W. Taylor Kimberly et al.   NEUROLOGY

Complications of Decompressive Craniectomy

(2018) M. S. Gopalakrishnan et al.   Frontiers in Neurology

SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling

(2017) Jesse A. Stokum et al.   GLIA

Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways

(2017) Ionica Pirici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Strategies to Attenuate Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment for Acute Ischemic Stroke

(2017) Masato Kanazawa et al.   Journal of Atherosclerosis and Thrombosis

Computed tomography-based quantification of lesion water uptake identifies patients within 4.5 hours of stroke onset: A multicenter observational study

(2016) Jens Minnerup et al.   ANNALS OF NEUROLOGY

Ipsilateral Sinus Hypoplasia and Poor Leptomeningeal Collaterals as Midline Shift Predictors

(2016) Ondrej Volny et al.   Journal of Stroke & Cerebrovascular Diseases

Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial

(2016) Kevin N Sheth et al.   LANCET NEUROLOGY

Microglia and Monocyte-Derived Macrophages in Stroke

(2016) Eunhee Kim et al.   Neurotherapeutics

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

(2016) Renée J. Turner et al.   Frontiers in Cellular Neuroscience

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Ipsilateral Sinus Hypoplasia and Poor Leptomeningeal Collaterals as Midline Shift Predictors

(2016) Ondrej Volny et al.   Journal of Stroke & Cerebrovascular Diseases

Prominence of Medullary Veins on Susceptibility-Weighted Images Provides Prognostic Information in Patients with Subacute Stroke

(2015) X. Yu et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC

(2015) Xia Wei et al.   BRAIN RESEARCH

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Molecular pathophysiology of cerebral edema

(2015) Jesse A Stokum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation

(2015) Prabodh Sadana et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The central role of aquaporins in the pathophysiology of ischemic stroke

(2015) Jasmine Vella   Frontiers in Cellular Neuroscience

Mechanisms of Astrocyte-Mediated Cerebral Edema

(2014) Jesse A. Stokum et al.   NEUROCHEMICAL RESEARCH

Exploratory Analysis of Glyburide as a Novel Therapy for Preventing Brain Swelling

(2014) Kevin N. Sheth et al.   Neurocritical Care

Roles of aquaporins and matrix metalloproteinases in mouse brain edema formation induced by subacute exposure to 1,2-dichloroethane

(2014) Gaoyang Wang et al.   NEUROTOXICOLOGY AND TERATOLOGY

Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke

(2014) Thomas W.K. Battey et al.   STROKE

Effect of ischemic postconditioning on cerebral edema and the AQP4 expression following hypoxic-eschemic brain damage in neonatal rats

(2014) Ling Yu et al.   World Journal of Pediatrics

The significance of matrix metalloproteinase (MMP)-2 and MMP-9 in the ischemic stroke

(2013) Jacek Kurzepa et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Sulfonylurea Receptor 1 Expression in Human Cerebral Infarcts

(2013) Rupal I. Mehta et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

The Sulfonylurea Receptor 1 (Sur1)-Transient Receptor Potential Melastatin 4 (Trpm4) Channel

(2012) Seung Kyoon Woo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

(2012) Jiankun Cui et al.   Molecular Neurodegeneration

An Antagomir to MicroRNA Let7f Promotes Neuroprotection in an Ischemic Stroke Model

(2012) Amutha Selvamani et al.   PLoS One

Sequential Activation of Hypoxia-Inducible Factor 1 and Specificity Protein 1 is Required for Hypoxia-Induced Transcriptional Stimulation of Abcc8

(2011) Seung Kyoon Woo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Hyperosmolar Therapy for Intracranial Hypertension

(2011) Andrew Torre-Healy et al.   Neurocritical Care

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Physiology and pathophysiology of matrix metalloproteases

(2010) T. Klein et al.   AMINO ACIDS

Cotransport of water by the Na+-K+-2Cl−cotransporter NKCC1 in mammalian epithelial cells

(2010) Steffen Hamann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cerebral Ischemia–Reperfusion Injury in Rats—A 3 T MRI Study on Biphasic Blood–Brain Barrier Opening and the Dynamics of Edema Formation

(2009) Deepu R Pillai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Water transport between CNS compartments: contributions of aquaporins and cotransporters

(2009) N. MacAulay et al.   NEUROSCIENCE

Hypoplasia or Occlusion of the Ipsilateral Cranial Venous Drainage Is Associated With Early Fatal Edema of Middle Cerebral Artery Infarction

(2009) Wengui Yu et al.   STROKE

SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator

(2008) J. Aittoniemi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES