Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways

Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels

(2017) Vigdis Andersen Eidsvaag et al.   GLIA

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

Pathogenesis of Brain Edema and Investigation into Anti-Edema Drugs

(2015) Shotaro Michinaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Different Dynamics of Aquaporin 4 and Glutamate Transporter-1 Distribution in the Perineuronal and Perivascular Compartments during Ischemic Stroke

(2014) Laurentiu Mogoanta et al.   BRAIN PATHOLOGY

Ultrastructural alterations of human cortical capillary basement membrane in human brain oedema

(2014) Orlando José Castejón   FOLIA NEUROPATHOLOGICA

Aquaporins: important but elusive drug targets

(2014) Alan S. Verkman et al.   NATURE REVIEWS DRUG DISCOVERY

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Fgf2 improves functional recovery-decreasing gliosis and increasing radial glia and neural progenitor cells after spinal cord injury

(2014) Yona Goldshmit et al.   Brain and Behavior

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

(2014) Gemma Llovera et al.   Jove-Journal of Visualized Experiments

Temporal Dynamics of Cerebral Blood Flow, Cortical Damage, Apoptosis, Astrocyte–Vasculature Interaction and Astrogliosis in the Pericontusional Region after Traumatic Brain Injury

(2014) Sonia Villapol et al.   Frontiers in Neurology

Disruption of dystroglycan–laminin interactions modulates water uptake by astrocytes

(2013) Brian T. Hawkins et al.   BRAIN RESEARCH

Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia

(2013) S Engelhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stroke-induced opposite and age-dependent changes of vessel-associated markers in co-morbid transgenic mice with Alzheimer-like alterations

(2013) Cheryl A. Hawkes et al.   EXPERIMENTAL NEUROLOGY

Posttraumatic Reduction of Edema with Aquaporin-4 RNA Interference Improves Acute and Chronic Functional Recovery

(2013) Andrew M Fukuda et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of aquaporin-4 significantly increases regional cerebral blood flow

(2013) Hironaka Igarashi et al.   NEUROREPORT

Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling

(2012) Oliver Braganza et al.   EPILEPSIA

Aquaporin-4 Positron Emission Tomography Imaging of the Human Brain: First Report

(2012) Yuji Suzuki et al.   JOURNAL OF NEUROIMAGING

Inflammation modulates expression of laminin in the central nervous system following ischemic injury

(2012) Kyungmin Ji et al.   Journal of Neuroinflammation

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Development of a Novel Ligand, [11C]TGN-020, for Aquaporin 4 Positron Emission Tomography Imaging

(2011) Yukihiro Nakamura et al.   ACS Chemical Neuroscience

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Brain Water Mobility Decreases after Astrocytic Aquaporin-4 Inhibition Using RNA Interference

(2010) Jérôme Badaut et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

(2010) Hironaka Igarashi et al.   NEUROLOGICAL SCIENCES

Effects of Granulocyte-Colony Stimulating Factor After Stroke in Aged Rats

(2010) Aurel Popa-Wagner et al.   STROKE

Identification of Aquaporin 4 inhibitors using in vitro and in silico methods

(2008) Vincent J. Huber et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Vascular Endothelial Growth Factor Receptor-1 Regulates Postnatal Angiogenesis Through Inhibition of the Excessive Activation of Akt

(2008) Jun-ichiro Nishi et al.   CIRCULATION RESEARCH

Glial Cell Aquaporin-4 Overexpression in Transgenic Mice Accelerates Cytotoxic Brain Swelling

(2008) Baoxue Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE