SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling

The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia

(2016) David B. Kurland et al.   Journal of Neuroinflammation

Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial

(2016) Kevin N Sheth et al.   LANCET NEUROLOGY

Structural and functional significance of water permeation through cotransporters

(2016) Thomas Zeuthen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular pathophysiology of cerebral edema

(2015) Jesse A Stokum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sur1-Trpm4 Cation Channel Expression in Human Cerebral Infarcts

(2015) Rupal I. Mehta et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The TRPM4 channel inhibitor 9-phenanthrol

(2014) R Guinamard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aggregation state determines the localization and function of M1– and M23–aquaporin-4 in astrocytes

(2014) Alex J. Smith et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of Astrocyte-Mediated Cerebral Edema

(2014) Jesse A. Stokum et al.   NEUROCHEMICAL RESEARCH

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Astrocytic Ca2+ waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia

(2013) Qi-ping Dong et al.   NEUROBIOLOGY OF DISEASE

TRPM4 inhibition promotes angiogenesis after ischemic stroke

(2013) Kok Poh Loh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation

(2012) Esther Steiner et al.   GLIA

The Sulfonylurea Receptor 1 (Sur1)-Transient Receptor Potential Melastatin 4 (Trpm4) Channel

(2012) Seung Kyoon Woo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aquaporin 4: a player in cerebral edema and neuroinflammation

(2012) Andrew M Fukuda et al.   Journal of Neuroinflammation

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

GATA6 reporter gene reveals myocardial phenotypic heterogeneity that is related to variations in gap junction coupling

(2011) Mathieu C. Rémond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Peptide Mimetic of the Connexin43 Carboxyl Terminus Reduces Gap Junction Remodeling and Induced Arrhythmia Following Ventricular Injury

(2011) Michael P. O'Quinn et al.   CIRCULATION RESEARCH

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

(2011) V. Benfenati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Na–K–Cl Co-transporter in astrocyte swelling

(2010) Arumugam R. Jayakumar et al.   METABOLIC BRAIN DISEASE

Water-Transporting Proteins

(2009) Thomas Zeuthen   JOURNAL OF MEMBRANE BIOLOGY

De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury

(2009) Volodymyr Gerzanich et al.   NATURE MEDICINE

Functional and molecular interactions between aquaporins and Na,K-ATPase

(2009) N.B. Illarionova et al.   NEUROSCIENCE

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

(2009) J. D. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photothrombosis ischemia stimulates a sustained astrocytic Ca2+signalingin vivo

(2008) Shinghua Ding et al.   GLIA