Article
Immunology
Seyed Mohammad Lellahi, Waqas Azeem, Yaping Hua, Benjamin Gabriel, Kristin Paulsen Rye, Hakon Reikvam, Karl-Henning Kalland
Summary: Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) are being considered as alternative options to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy. However, the low numbers of cDCs in peripheral blood and their extensive spontaneous apoptosis and death in culture within 24hrs pose challenges. The study found that GM-CSF improved the viability of both cDC1 and cDC2, while Flt3-L and IL-4 specifically increased the viability of cDC1 and cDC2, respectively. Combinations of these three cytokines further improved the viability of both cDCs at different time points.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Francisco J. Cueto, David Sancho
Summary: Current cancer immunotherapy efforts focus on enhancing T cell effector function, but stimulating dendritic cells (DCs) may improve treatment outcomes. Specifically, utilizing the Flt3/Flt3L axis to boost DC function shows promising potential for cancer immunotherapy.
Article
Immunology
Megan S. Molina, Emely A. Hoffman, Jessica Stokes, Nicole Kummet, Kyle A. Smith, Forrest Baker, Tiffany M. Zuniga, Richard J. Simpson, Emmanuel Katsanis
Summary: Flt3 ligand is crucial for DC homeostasis and development, controlling survival and proliferation by binding to its receptor on DCs' surface. Exposure to bendamustine increases Flt3 expression on both mouse and human-derived DCs, favoring the development of specific DC subsets. Bendamustine exposure is associated with a distinct regulatory phenotype, cytokine response, and T-cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Kayla R. Wilson, Jose A. Villadangos, Justine D. Mintern
Summary: Dendritic cells (DCs) play a crucial role in initiating immune responses. Understanding the Flt3 signaling pathway could provide new insights for vaccine development and treatment of autoimmune diseases.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Immunology
Moah Sohn, Hye Young Na, Hyun Soo Shin, Seul Hye Ryu, Sejung Park, Hyunju In, Wanho Choi, Ji Soo Park, Soomin Hwang, Min Kyung Chu, Chae Gyu Park
Summary: The study found that classical DC subsets in the peritoneal cavity regulate T cell responses differently, with cDC1s being superior in activating CD8 T cells and cDC2s prominently expressing homing receptors for CD4 T cells. The study also revealed that soluble factors from CD8 T cells stimulated by cDC1s, particularly IL-2, play a crucial role in controlling the overall gene expression of T cells. Overall, the different peritoneal cDC subsets effectively diversify T cell responses by altering the level of cytokines, such as IL-2, in the environment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tianxiao Liu, Zhaojie Meng, Jing Liu, Jie Li, Yuanyuan Zhang, Zhiyong Deng, Songyuan Luo, Minjie Wang, Qin Huang, Shuya Zhang, Pauline Fendt, Julie Devouassoux, Dazhu Li, Andrew Neil James McKenzie, Matthias Nahrendorf, Peter Libby, Junli Guo, Guo Ping Shi
Summary: This study revealed an indirect cardiac reparative role of ILC2 in post-MI hearts via the IL5, EOS, and DC mechanism.
CARDIOVASCULAR RESEARCH
(2023)
Article
Immunology
Alan Benard, Frederik J. Hansen, Florian Uhle, Bettina Kloesch, Franziska Czubayko, Anke Mittelstaedt, Anne Jacobsen, Paul David, Malgorzata J. Podolska, Anna Anthuber, Izabela Swierzy, Dominik Schaack, Petra Muehl-Zuerbes, Alexander Steinkasserer, Michael Weyand, Markus A. Weigand, Thorsten Brenner, Christian Krautz, Robert Gruetzmann, Georg F. Weber
Summary: IL-3 plays a crucial role in viral pneumonia during sepsis. Low levels of IL-3 are associated with increased herpes simplex virus (HSV) airway infections and reduced survival in septic patients. Mechanistically, IL-3 enhances antiviral immunity by promoting the recruitment of circulating plasmacytoid dendritic cells (pDCs) into the airways and enhancing pDC-mediated T cell activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lily Chan, Yeganeh Mehrani, Jessica A. Minott, Byram W. Bridle, Khalil Karimi
Summary: This research examined the effects of DC vaccination on ILC2 populations and their cytokine production. The results showed an increase in the number of ILC2s in certain areas in the absence of tumors, indicating a complex interplay between DC vaccines and ILC2s.
Article
Immunology
Katarzyna Wegierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygiel, Joanna Rossowska, Anna Wroblewska, Marta Switalska, Tomasz M. Goszczynski, Bozena Szermer-Olearnik, Elzbieta Pajtasz-Piasecka
Summary: This study aimed to determine whether administering HES-MTX before immunotherapy with anti-IL-10R antibodies would change the effectiveness of dendritic cell vaccines that overproduce proinflammatory cytokines IL-12, IL-15, or IL-18. The results showed that using the HES-MTX nanoconjugate created optimal conditions for the effective action of these vaccines in a murine colon carcinoma model. The treatment schedule may be promising in anticancer therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jin Zhang, Zhenghui Li, Akila Chandrasekar, Shun Li, Albert Ludolph, Tobias Maria Boeckers, Markus Huber-Lang, Francesco Roselli, Florian Olde Heuvel
Summary: The consequences of systemic inflammation after traumatic brain injury (TBI) are a significant burden on almost all organs, with inflammation and immunosuppression occurring concurrently. The spleen, as one of the main immune regulatory organs, interacts extensively with the brain. Nerve fibers and brain-derived circulating mediators have been observed to directly interact with immune cells in the spleen along the brain-spleen axis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuena Yang, Beiting Su, Jing Liu, Li Zheng, Peizhi Tao, Yusen Lin, Xiaoling Zou, Hailing Yang, Wenbin Wu, Ping Meng, Tiantuo Zhang, Hongtao Li
Summary: Tobacco smoke exposure is a significant risk factor for the development and progression of asthma. CpG oligodeoxynucleotide (CpG-ODN) has been shown to inhibit TSLP-dendritic cells and reduce Th2/Th17-related inflammatory response in smoke-related asthma, but the mechanism is unclear. In this study, a combined house dust mite (HDM)/cigarette smoke extract (CSE) model was used to investigate the effects of CpG-ODN on airway inflammation and immune response. The results demonstrated that CpG-ODN attenuated airway inflammation, collagen deposition, and goblet cell hyperplasia in the combined model. In vitro experiments also showed that CpG-ODN inhibited TSLP production in bronchial epithelial cells. The underlying mechanism may involve the downregulation of the IL-33/ST2 axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Giorgia De Simone, Francesco Andreata, Camille Bleriot, Valeria Fumagalli, Chiara Laura, Jose M. Garcia-Manteiga, Pietro Di Lucia, Stefano Gilotto, Xenia Ficht, Federico F. De Ponti, Elisa B. Bono, Leonardo Giustini, Gioia Ambrosi, Marta Mainetti, Paola Zordan, Alexandre P. Benechet, Micol Rava, Svetoslav Chakarov, Federica Moalli, Marc Bajenoff, Luca G. Guidotti, Florent Ginhoux, Matteo Iannacone
Summary: The study identified a subset of KCs, referred to as KC2, that can cross-present hepatocellular antigens under IL-2 administration to improve T cell antiviral function. By sensing IL-2 and presenting antigens, KC2 can overcome the tolerogenic potential of the hepatic microenvironment, suggesting new strategies for enhancing hepatic T cell immunity.
Article
Immunology
Fatemeh Ahmadi, Fredrik Junghus, Christian Ashworth, Amanda Lappalainen, Urs Morbe, Knut Kotarsky, William W. Agace
Summary: This study reveals that the post-weaning accumulation of Th1 cells in the intestine, which is microbiota-dependent, requires the expression of MHC-II and IL-27 by cDC1 cells. IL-27 derived from cDC1 cells plays a crucial role in maintaining the balance between Th1 and Th17 cells in the small intestinal lamina propria.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Cedric Bosteels, Kaat Fierens, Sofie De Prijck, Justine Van Moorleghem, Manon Vanheerswynghels, Caroline De Wolf, Aurelie Chalon, Catherine Collignon, Hamida Hammad, Arnaud M. Didierlaurent, Bart N. Lambrecht
Summary: The AS01 adjuvant system containing MPL and QS-21 in liposomal formulation is crucial for the recruitment and activation of dendritic cells, particularly cDC2s and inf-cDC2s, which play a significant role in priming antigen-specific T cell responses post-vaccination. Depletion of these DC subsets results in the abrogation of adaptive immune responses, highlighting their importance in the adjuvant activity of AS01.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Nils Scheib, Jessica Tiemann, Christian Becker, Hans Christian Probst, Verena Katharina Raker, Kerstin Steinbrink
Summary: This review discusses the important role of dendritic cells in initiating and regulating immune responses. It focuses on the changes in dendritic cells in skin diseases and the potential for therapeutic reprogramming. The interactions with regulatory T cells are also highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jeffrey D. Price, Chie Hotta-Iwamura, Yongge Zhao, Nicole M. Beauchamp, Kristin V. Tarbell
Letter
Endocrinology & Metabolism
Yongge Zhao, Kristin V. Tarbell
Review
Immunology
Jeffrey D. Pricet, Kristin V. Tarbell
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Medicine, Research & Experimental
Jeremie Decalf, Kristin V. Tarbell, Armanda Casrouge, Jeffrey D. Price, Grace Linder, Estelle Mottez, Philippe Sultanik, Vincent Mallet, Stanislas Pol, Darragh Duffy, Matthew L. Albert
EMBO MOLECULAR MEDICINE
(2016)
Article
Biochemical Research Methods
Matthew B. Dong, M. Jubayer Rahman, Kristin V. Tarbell
JOURNAL OF IMMUNOLOGICAL METHODS
(2016)
Article
Immunology
M. Jubayer Rahman, Gwendoline Rahir, Matthew B. Dong, Yongge Zhao, Kameron B. Rodrigues, Chie Hotta-Iwamura, Ye Chen, Alan Guerrero, Kristin V. Tarbell
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Allison M. W. Malloy, Tracy J. Ruckwardt, Kaitlyn M. Morabito, Annie W. Lau-Kilby, Barney S. Graham
JOURNAL OF IMMUNOLOGY
(2017)
Review
Cell Biology
Chie Hotta-Iwamura, Kristin V. Tarbell
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Cell Biology
Jeffrey D. Price, Nicole M. Beauchamp, Gwendoline Rahir, Yongge Zhao, Cosima C. Rieger, Annie W. Lau-Kilby, Kristin V. Tarbell
JOURNAL OF LEUKOCYTE BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Daphne A. Stanley, Anna N. Honko, Clement Asiedu, John C. Trefry, Annie W. Lau-Kilby, Joshua C. Johnson, Lisa Hensley, Virginia Ammendola, Adele Abbate, Fabiana Grazioli, Kathryn E. Foulds, Cheng Cheng, Lingshu Wang, Mitzi M. Donaldson, Stefano Colloca, Antonella Folgori, Mario Roederer, Gary J. Nabel, John Mascola, Alfredo Nicosia, Riccardo Cortese, Richard A. Koup, Nancy J. Sullivan
Article
Virology
Matthew S. Sutton, Amy Ellis-Connell, Alexis J. Balgeman, Gabrielle Barry, Andrea M. Weiler, Scott J. Hetzel, Yan Zhou, Annie W. Lau-Kilby, Rosemarie D. Mason, Kristin K. Biris, John R. Mascola, Nancy J. Sullivan, Mario Roederer, Thomas C. Friedrich, Shelby L. O'Conn
JOURNAL OF VIROLOGY
(2019)
Article
Immunology
Annie W. Lau-Kilby, Mathilde Turfkruyer, Margaret Kehl, Lijuan Yang, Ursula J. Buchholz, Kimberly Hickey, Allison M. W. Malloy
MUCOSAL IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
M. Jubayer Rahman, Kameron B. Rodrigues, Juan A. Quiel, Yi Liu, Vipul Bhargava, Yongge Zhao, Chie Hotta-Iwamura, Han-Yu Shih, Annie W. Lau-Kilby, Allison M. W. Malloy, Timothy W. Thoner, Kristin V. Tarbell