Journal
GENES AND IMMUNITY
Volume 10, Issue -, Pages S60-S63Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gene.2009.93
Keywords
autoimmune disease; VDR; genetic susceptibility; vitamin D; single nucleotide polymorphism; type I diabetes
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Human Genome Research Institute (NHGRI)
- National Institute of Child Health and Human Development (NICHD)
- Juvenile Diabetes Research Foundation International (JDRF)
- Wellcome Trust
- National Institute for Health Research Biomedical Research Centre
- National Center for Research Resources [U54 RR020278]
- [U01 DK062418]
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Type I diabetes (T1D) results from interactions between environmental exposures and genetic susceptibility leading to immune dysfunction and destruction of the insulin-producing beta cells of the pancreas. Vitamin D deficiency is likely to be one of the many environmental factors influencing T1D development and diagnosis, and, hence, the hormone receptor gene, VDR, was examined for association with T1D risk. The Type I Diabetes Genetics Consortium genotyped 38 single nucleotide polymorphisms (SNPs) in 1654 T1D nuclear families (6707 individuals, 3399 affected). Genotypes for 38 SNPs were assigned using the Illumina (ILMN) and Sequenom (SQN) technology. The analysis of data release as of July 2008 is reported for both platforms. No evidence of association of VDR SNPs with T1D at P<0.01 was obtained in the overall sample set, nor in subgroups analyses of the parent-of-origin, sex of offspring and HLA risk once adjusted for multiple testing. Genes and Immunity (2009) 10, S60-S63; doi:10.1038/gene.2009.93
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