TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes

Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN- / 

(2014) S. M. Ngoi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Overlapping Functions of TLR7 and TLR9 for Innate Defense against a Herpesvirus Infection

(2014) Nicolas Zucchini et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses

(2014) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

The role of interferon alpha in initiation of type I diabetes in the NOD mouse

(2011) Qing Li et al.   CLINICAL IMMUNOLOGY

IFN-α-producing PDCA-1+Siglec-H− B cells mediate innate immune defense by activating NK cells

(2011) Yan Bao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

(2011) Boyoun Park et al.   IMMUNITY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

(2011) Zhiqiang Zhang et al.   IMMUNITY

RNA sensor–induced type I IFN prevents diabetes caused by a β cell–tropic virus in mice

(2011) Stephen A. McCartney et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Viral infection prevents diabetes by inducing regulatory T cells through NKT cell–plasmacytoid dendritic cell interplay

(2011) Julien Diana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway

(2011) S. Davidson et al.   JOURNAL OF IMMUNOLOGY

The type I interferon system in the development of lupus

(2011) Lars Rönnblom et al.   SEMINARS IN IMMUNOLOGY

RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection

(2011) A. M. A. Nasirudeen et al.   PLoS Neglected Tropical Diseases

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Natural killer cells are required for accelerated type 1 diabetes driven by interferon-β

(2010) A. Alba et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Recognition of viruses by cytoplasmic sensors

(2010) Courtney Wilkins et al.   CURRENT OPINION IN IMMUNOLOGY

Protection against or triggering of Type 1 diabetes? Different roles for viral infections

(2010) Tobias Boettler et al.   Expert Review of Clinical Immunology

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice

(2010) Philipp A. Lang et al.   HEPATOLOGY

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

(2010) Melissa Swiecki et al.   IMMUNITY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

TLR9 Contributes to the Recognition of EBV by Primary Monocytes and Plasmacytoid Dendritic Cells

(2010) S. Fiola et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Polyinosinic:Polycytidylic Acid Boosts the Generation of Memory CD8 T Cells through Melanoma Differentiation-Associated Protein 5 Expressed in Stromal Cells

(2010) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Induction and Inhibition of Type I Interferon Responses by Distinct Components of Lymphocytic Choriomeningitis Virus

(2010) S. Zhou et al.   JOURNAL OF VIROLOGY

Respiratory Syncytial Virus-Mediated NF- B p65 Phosphorylation at Serine 536 Is Dependent on RIG-I, TRAF6, and IKK 

(2010) F. Yoboua et al.   JOURNAL OF VIROLOGY

Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

(2010) Matteo Iannacone et al.   NATURE

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host

(2010) Didier Hober et al.   Nature Reviews Endocrinology

Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes

(2010) Kate Downes et al.   PLoS One

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

(2010) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

(2010) A. L. Blasius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection

(2010) Michael H. Hühn et al.   VIROLOGY

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium

(2010) Louise Slater et al.   PLoS Pathogens

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

(2010) Leonid Gitlin et al.   PLoS Pathogens

Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q

(2009) M. Yoshizaki et al.   BLOOD

Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells

(2009) R. Colisson et al.   BLOOD

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection

(2009) Christian Steinberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

NKT Cell-Plasmacytoid Dendritic Cell Cooperation via OX40 Controls Viral Infection in a Tissue-Specific Manner

(2009) Julien Diana et al.   IMMUNITY

Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5

(2009) Taeko Shigemoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells

(2009) Stephen McCartney et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: TLR-Dependent Viral Recognition Along with Type I IFN Positive Feedback Signaling Masks the Requirement of Viral Replication for IFN-  Production in Plasmacytoid Dendritic Cells

(2009) Y. Kumagai et al.   JOURNAL OF IMMUNOLOGY

Poly I:C-Induced Activation of NK Cells by CD8 + Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways

(2009) T. Miyake et al.   JOURNAL OF IMMUNOLOGY

Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses

(2009) Q. Wang et al.   JOURNAL OF IMMUNOLOGY

Both RIG-I and MDA5 RNA Helicases Contribute to the Induction of Alpha/Beta Interferon in Measles Virus-Infected Human Cells

(2009) S. Ikegame et al.   JOURNAL OF VIROLOGY

Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

(2009) A. Pichlmair et al.   JOURNAL OF VIROLOGY

MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus

(2009) J. P. Wang et al.   JOURNAL OF VIROLOGY

A virus–gene collaboration

(2009) Matthias von Herrath   NATURE

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

The activating receptor NKp46 is essential for the development of type 1 diabetes

(2009) Chamutal Gur et al.   NATURE IMMUNOLOGY

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

Toll-Like Receptor 3 Signaling on Macrophages Is Required for Survival Following Coxsackievirus B4 Infection

(2009) Martin J. Richer et al.   PLoS One

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Characterization of the Interferon-Producing Cell in Mice Infected with Listeria monocytogenes

(2009) Silvia Stockinger et al.   PLoS Pathogens

Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

(2009) Christiane Stahl-Hennig et al.   PLoS Pathogens

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS

Hematopoietic cell-derived interferon controls viral replication and virus-induced disease

(2008) P. A. Lang et al.   BLOOD

Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

(2008) Babacar Cisse et al.   CELL

Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections

(2008) Ken J. Ishii et al.   Cell Host & Microbe

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

(2008) J. S. Allen et al.   DIABETES

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

RNA recognition and signal transduction by RIG-I-like receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNOLOGICAL REVIEWS

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling

(2008) S. Liao et al.   JOURNAL OF GENERAL VIROLOGY

Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia

(2008) J. K. Roth-Cross et al.   JOURNAL OF VIROLOGY

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

(2008) S. Daffis et al.   JOURNAL OF VIROLOGY

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

(2008) Sheng Cui et al.   MOLECULAR CELL

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

Translational control of the innate immune response through IRF-7

(2008) Rodney Colina et al.   NATURE

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

(2008) C. Trumpfheller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

(2008) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-  initiates type 1 diabetes in nonobese diabetic mice

(2008) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key Role of Splenic Myeloid DCs in the IFN-αβ Response to Adenoviruses In Vivo

(2008) György Fejer et al.   PLoS Pathogens

MDA-5 Recognition of a Murine Norovirus

(2008) Stephen A. McCartney et al.   PLoS Pathogens