Article
Cardiac & Cardiovascular Systems
Matthew R. Alexander, Samuel Hank, Bethany L. Dale, Lauren Himmel, Xue Zhong, Charles D. Smart, Daniel J. Fehrenbach, Yuhan Chen, Nitin Prabakaran, Brian Tirado, Megan Centrella, Mingfang Ao, Liping Du, Yu Shyr, Daniel Levy, Meena S. Madhur
Summary: Research suggests that the Trp encoding allele of rs3184504 may be causal for hypertension and renal dysfunction, in part due to the loss of SH2B3-mediated repression of T cell IL-12 signaling leading to enhanced IFNg production.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Review
Plant Sciences
Zheng Ying, Muhammad Awais, Reshmi Akter, Fengjiao Xu, Sul Baik, Daehyo Jung, Deok Chun Yang, Gi-Young Kwak, Wenying You
Summary: Discriminating plant species, cultivars, and landraces is challenging, but SNP markers have proven to be a reliable tool for differentiating Panax ginseng and similar species. This article provides a cost-effective guide for SNP marker analysis in a traditional laboratory setting.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemical Research Methods
Miranda N. Emaus, Jared L. Anderson
Summary: Sequence-specific DNA extractions using ion-tagged oligonucleotides (ITOs) combined with a hydrophobic magnetic ionic liquid (MIL) show high selectivity and sensitivity in extracting diluted BRAF V600E mutations, allowing for the differentiation of low abundance mutations during qPCR analysis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Psychiatry
Kumaraswamy Naidu Chitrala, Prakash Nagarkatti, Mitzi Nagarkatti
Summary: This study analyzed the impact of deleterious SNPs in the COMT gene associated with PTSD using computational approaches and molecular dynamic simulations. The SNP rs4680 (V158M) in COMT was found to have a deleterious effect on PTSD. Results from molecular dynamics simulations showed significant structural fluctuations between wild-type and mutant forms of the COMT protein.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Justyna Basak, Danuta Piotrzkowska, Ireneusz Majsterek, Ewa Kucharska
Summary: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system with no cure and unclear etiology. This study aimed to identify SNPs associated with an increased risk of developing MS. The findings suggest that the GG AGO1 rs636832 and AA GEMIN4 rs7813 genotypes are associated with an increased risk of MS.
Article
Immunology
Yan Li, Wei Li, Li Huang, Huijia Li, Peipeng He, Chao Xue
Summary: This study investigated the association between microscopic polyangiitis and the single nucleotide polymorphism rs807185 in autophagy-associated gene 4A (ATG4A) in the Chinese population. Using multiplex polymerase chain reaction and high-throughput sequencing, it was found that the control group had a higher frequency of the A allele of rs807185 compared to the microscopic polyangiitis group, suggesting that the A allele of rs807185 may have a protective effect against microscopic polyangiitis in the Chinese population. However, the molecular mechanisms remain unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Alison Paolo N. Bareng, Lynn Grignard, Ralph Reyes, Kim Fornace, Freya Spencer, Ma Lourdes Macalinao, Jennifer Luchavez, Fe Esperanza Espino, Chris Drakeley, Julius Clemence R. Hafalla
Summary: This study provides 2016 data on the prevalence of key single nucleotide polymorphisms (SNPs) associated with antimalarial drug resistance in Palawan, Philippines. The findings suggest that the current drugs remain effective and there is limited importation and establishment of resistant parasites in the area. The study also recognizes clear temporal trends in the prevalence of certain mutations, consistent with a change in antimalarial drug policy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Concetta Scimone, Luigi Donato, Simona Alibrandi, Concetta Alafaci, Angela D'Ascola, Sergio Vinci, Rosalia D'Angelo, Antonina Sidoti
Summary: This study reveals the importance of epitranscriptomic modifications in gene expression regulation and suggests the involvement of altered epitranscriptome profile in the development of CCM. These findings provide new insights for further investigation into the pathogenesis of CCM.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Cell Biology
Farbod Bahreini, Elham Rayzan, Nima Rezaei
Summary: Breast cancer, a multifactorial disease, may have an increased risk due to alterations in microRNA sequences. miR-SNPs are potential biomarkers for early detection of breast cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jonas Schmidt, Sandro Berghaus, Frithjof Blessing, Holger Herbeck, Josef Blessing, Peter Schierack, Stefan Rodiger, Dirk Roggenbuck, Folker Wenzel
Summary: Nanopore sequencing has great potential for clinical diagnostics, but further validation and certification are required.
Article
Plant Sciences
Xi-ou Xiao, Ning Zhang, Hui Jin, Huaijun Si
Summary: This study evaluated the genetic diversity and population structure of 135 autotetraploid potatoes using SLAF-seq methods. Analysis of 3,397,137 high-quality SNPs revealed that the classification of these potatoes based on SNP profiles did not correlate with their geographical origins. Furthermore, 71 PARMS-SNP markers were successfully used to analyze 190 autotetraploid potato varieties. Overall, these novel SNP markers provide a solid foundation for potato genetic diversity analysis, DUS testing, and plant variety protection.
Article
Medicine, General & Internal
Piotr Macek, Mieszko Wieckiewicz, Rafal Poreba, Pawel Gac, Katarzyna Bogunia-Kubik, Marta Dratwa, Anna Wojakowska, Grzegorz Mazur, Helena Martynowicz
Summary: This study investigated the relationship between SNP of the TERT gene and the severity of sleep bruxism, and identified the independent risk factors for sleep bruxism. The results showed that one SNP of TERT was associated with the episode index of phasic bruxism, and the lack of this SNP, male sex, and arterial hypertension were independent risk factors for phasic bruxism.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Food Science & Technology
Joanna Bucka-Kolendo, Barbara Sokolowska
Summary: This study evaluated the impact of high hydrostatic pressure (HHP) on stress-response mechanism-related genes in lactic acid bacteria (LAB). The findings showed changes in gene expression after HHP treatment, but no correlation with single nucleotide polymorphisms (SNPs). The number and diversity of mutations varied among different genes. Further research is needed to understand the general mechanisms and changes in membranes' composition, proteome, and gene expression patterns.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2022)
Article
Gastroenterology & Hepatology
Kara Wegermann, Melanie E. Garrett, Jiayin Zheng, Andrea Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein-Chung Chow, Cynthia D. Guy, Anna Mae Diehl, Allison Ashley-Koch, Ayako Suzuki
Summary: The study found that sex and menopausal status significantly influence the effect of metabolism-related single nucleotide polymorphisms (SNPs) on the development of fibrosis in nonalcoholic fatty liver disease (NAFLD), with 10 loci identified to be relevant to fibrosis progression.
HEPATOLOGY COMMUNICATIONS
(2021)