Maresin 2 is an analgesic specialized pro-resolution lipid mediator in mice by inhibiting neutrophil and monocyte recruitment, nociceptor neuron TRPV1 and TRPA1 activation, and CGRP release

Harnessing Inflammation Resolution in Arthritis: Current Understanding of Specialized Pro-resolving Lipid Mediators’ Contribution to Arthritis Physiopathology and Future Perspectives

(2021) Tiago H. Zaninelli et al.   Frontiers in Physiology

Diosmin Treats Lipopolysaccharide-Induced Inflammatory Pain and Peritonitis by Blocking NF-κB Activation in Mice

(2020) Victor Fattori et al.   JOURNAL OF NATURAL PRODUCTS

Imbalance of pro-resolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis

(2020) Benjamin L. Allen et al.   PAIN

ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020

(2020) Elliott Lilley et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification

(2020) Maja Payrits et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential

(2020) Bao-Chun Jiang et al.   PHARMACOLOGY & THERAPEUTICS

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling

(2020) Yi-hao Wang et al.   Frontiers in Neuroscience

Neuroimmune communication in infection and pain: Friends or foes?

(2020) Victor Fattori et al.   IMMUNOLOGY LETTERS

The specialised pro‐resolving lipid mediator maresin 1 reduces inflammatory pain with a long‐lasting analgesic effect

(2019) Victor Fattori et al.   BRITISH JOURNAL OF PHARMACOLOGY

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Specialized pro-resolving lipid mediators: A new class of non-immunosuppressive and non-opioid analgesic drugs

(2019) Victor Fattori et al.   PHARMACOLOGICAL RESEARCH

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

(2018) Jesmond Dalli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential effects of lipopolysaccharide on mouse sensory TRP channels

(2018) Brett Boonen et al.   CELL CALCIUM

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

(2018) Pankaj Baral et al.   NATURE MEDICINE

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314

(2018) Kimbria J. Blake et al.   Nature Communications

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice

(2018) Linlin Zhang et al.   Frontiers in Pharmacology

Pro-resolving mediator maresin 1 ameliorates pain hypersensitivity in a rat spinal nerve ligation model of neuropathic pain

(2018) Jie Gao et al.   Journal of Pain Research

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

(2017) M Codagnone et al.   Mucosal Immunology

Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-κB activation in mice

(2017) Victor Fattori et al.   PHARMACOLOGICAL RESEARCH

Resolvin D1 Inhibits Mechanical Hypersensitivity in Sciatica by Modulating the Expression of Nuclear Factor-κB, Phospho-extracellular Signal–regulated Kinase, and Pro- and Antiinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion

(2016) Zhi-hua Liu et al.   ANESTHESIOLOGY

Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state

(2016) Sarah A. Woller et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

(2016) Alessandra Cadete Martini et al.   Journal of Neuroinflammation

Naringenin reduces inflammatory pain in mice

(2016) Felipe A. Pinho-Ribeiro et al.   NEUROPHARMACOLOGY

Lipopolysaccharide-induced hemolysis: Evidence for direct membrane interactions

(2016) Stephan Brauckmann et al.   Scientific Reports

Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB

(2015) Kenji W. Ruiz-Miyazawa et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Nonsteroidal Anti-inflammatory Drugs and Risk of Incident Heart Failure: A Systematic Review and Meta-analysis of Observational Studies

(2015) Patompong Ungprasert et al.   CLINICAL CARDIOLOGY

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

(2015) Christine M. Sandiego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First total synthesis of the macrophage derived anti-inflammatory and pro-resolving lipid mediator Maresin 2

(2015) Ana R. Rodriguez et al.   TETRAHEDRON LETTERS

Analgesic effects of botulinum neurotoxin type A in a model of allyl isothiocyanate- and capsaicin-induced pain in mice

(2015) Siro Luvisetto et al.   TOXICON

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw

(2014) Igor L. Calil et al.   PLoS One

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

(2014) Raja-Elie E. Abdulnour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS

(2012) Martin Giera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Resolvin E1 Inhibits Neuropathic Pain and Spinal Cord Microglial Activation Following Peripheral Nerve Injury

(2012) Zhen-Zhong Xu et al.   Journal of Neuroimmune Pharmacology

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation

(2012) Antonio Recchiuti et al.   Frontiers in Immunology

Prospects for treating osteoarthritis: enzyme–protein interactions regulating matrix metalloproteinase activity

(2012) Evan Meszaros et al.   Therapeutic Advances in Chronic Disease

Transcriptomic analyses of murine resolution-phase macrophages

(2011) M. J. Stables et al.   BLOOD

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Specialized pro-resolving lipid mediators in the inflammatory response: An update

(2010) Gerard Bannenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipoxin A4 attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects

(2010) FP Conte et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Causes and Consequences of Inadequate Management of Acute Pain

(2010) Raymond Sinatra   PAIN MEDICINE

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

Chemokines as pain mediators and modulators

(2008) Fletcher A White et al.   Current Opinion in Anesthesiology

Crucial role of neutrophils in the development of mechanical inflammatory hypernociception

(2008) T. M. Cunha et al.   JOURNAL OF LEUKOCYTE BIOLOGY