Neuroimmune communication in infection and pain: Friends or foes?

Unraveling the Plastic Peripheral Neuroimmune Interactome

(2020) Aakanksha Jain et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough

(2020) Cody R. Ruhl et al.   CELL

Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain

(2020) Paulino Barragán-Iglesias et al.   JOURNAL OF NEUROSCIENCE

Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis

(2019) Yu Hao et al.   MEDIATORS OF INFLAMMATION

Neuro-immune crosstalk and allergic inflammation

(2019) Hiroki Kabata et al.   JOURNAL OF CLINICAL INVESTIGATION

The specialised pro‐resolving lipid mediator maresin 1 reduces inflammatory pain with a long‐lasting analgesic effect

(2019) Victor Fattori et al.   BRITISH JOURNAL OF PHARMACOLOGY

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice

(2019) Sergio M. Borghi et al.   Journal of Neuroinflammation

Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity

(2019) Jonathan A. Cohen et al.   CELL

Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

(2019) Hiroyuki Nagashima et al.   IMMUNITY

Cartilage-binding antibodies induce pain through immune complex–mediated activation of neurons

(2019) Alex Bersellini Farinotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine

(2019) Richard B. Lipton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting nitric oxide as a key modulator of sepsis, arthritis and pain

(2019) Fernando Spiller et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

(2019) Heping Xu et al.   IMMUNITY

Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of Migraine

(2019) Richard B. Lipton et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation

(2019) Nadine Serhan et al.   NATURE IMMUNOLOGY

Specialized pro-resolving lipid mediators: A new class of non-immunosuppressive and non-opioid analgesic drugs

(2019) Victor Fattori et al.   PHARMACOLOGICAL RESEARCH

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

(2018) Felipe A. Pinho-Ribeiro et al.   CELL

Differential effects of lipopolysaccharide on mouse sensory TRP channels

(2018) Brett Boonen et al.   CELL CALCIUM

Lipoxin A4 inhibits UV radiation-induced skin inflammation and oxidative stress in mice

(2018) R.M. Martinez et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome

(2018) Wen-Wu Li et al.   Journal of Neuroinflammation

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

(2018) Pankaj Baral et al.   NATURE MEDICINE

Pulmonary neuroendocrine cells amplify allergic asthma responses

(2018) Pengfei Sui et al.   SCIENCE

Neuronal–immune system cross-talk in homeostasis

(2018) Henrique Veiga-Fernandes et al.   SCIENCE

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314

(2018) Kimbria J. Blake et al.   Nature Communications

Neuro–Immune Cell Units: A New Paradigm in Physiology

(2018) Cristina Godinho-Silva et al.   Annual Review of Immunology

Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids

(2018) Charles N. Serhan et al.   JOURNAL OF IMMUNOLOGY

Mast Cells in Neuroimmune Interactions

(2018) Paul Forsythe   TRENDS IN NEUROSCIENCES

Targeting IL-33/ST2 signaling: regulation of immune function and analgesia

(2017) Victor Fattori et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

(2017) Jesmond Dalli et al.   IMMUNITY

Blocking CGRP in migraine patients – a review of pros and cons

(2017) Marie Deen et al.   JOURNAL OF HEADACHE AND PAIN

Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis

(2017) Susmit Suvas   JOURNAL OF IMMUNOLOGY

Bacterial Signaling to the Nervous System through Toxins and Metabolites

(2017) Nicole J. Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Neuroimmune–Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia

(2017) Jaqueline R. Silva et al.   JOURNAL OF NEUROSCIENCE

HSV-1 interaction to 3-O-sulfated heparan sulfate in mouse-derived DRG explant and profiles of inflammatory markers during virus infection

(2017) Harsh Sharthiya et al.   JOURNAL OF NEUROVIROLOGY

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

(2017) M Codagnone et al.   Mucosal Immunology

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

(2017) Felipe A. Pinho-Ribeiro et al.   TRENDS IN IMMUNOLOGY

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis

(2017) Kenta Maruyama et al.   Cell Reports

Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype

(2017) Haifa Xia et al.   Scientific Reports

The Role of Substance P in Pulmonary Clearance of Bacteria in Comparative Injury Models

(2016) Terry Hsieh et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuro-Immune Interactions at Barrier Surfaces

(2016) Henrique Veiga-Fernandes et al.   CELL

A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine

(2016) Tiffini Voss et al.   CEPHALALGIA

Leishmania infection: painful or painless?

(2016) Sergio M. Borghi et al.   PARASITOLOGY RESEARCH

Neutrophils and arthritis: Role in disease and pharmacological perspectives

(2016) Victor Fattori et al.   PHARMACOLOGICAL RESEARCH

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

(2016) Frieda A. Koopman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase

(2016) Lei Huang et al.   PLoS Pathogens

Infecções graves em pacientes com artrite reumatoide em uso de anakinra, rituximab ou abatacept: revisão sistemática de estudos observacionais

(2016) Vanderlea Poeys Cabral et al.   Revista Brasileira De Reumatologia

Identification of novel mechanisms involved in generating localized vulvodynia pain

(2015) Megan L. Falsetta et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Vasoactive intestinal peptide reduces the inflammatory profile in mice infected with Trypanosoma cruzi

(2015) Pulchéria Maria Silva Higyno et al.   EXPERIMENTAL PARASITOLOGY

Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity

(2015) Sakeen W. Kashem et al.   IMMUNITY

Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes

(2015) Chin-Wei Wang et al.   INFECTION AND IMMUNITY

Mast Cell-Mediated Mechanisms of Nociception

(2015) Anupam Aich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gp120 in the pathogenesis of human immunodeficiency virus-associated pain

(2014) Su-Bo Yuan et al.   ANNALS OF NEUROLOGY

Autonomic regulation of cellular immune function

(2014) Denise L. Bellinger et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

Neuroimmunological communication via CGRP promotes the development of a regulatory phenotype in TLR4-stimulated macrophages

(2014) Mariona Baliu-Piqué et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vagus nerve controls resolution and pro-resolving mediators of inflammation

(2014) Valbona Mirakaj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Morphine Induces Defects in Early Response of Alveolar Macrophages to Streptococcus pneumoniae by Modulating TLR9-NF- B Signaling

(2014) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

(2014) Lorena Riol-Blanco et al.   NATURE

Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw

(2014) Igor L. Calil et al.   PLoS One

Neuroendocrine regulation of inflammation

(2014) Caroline J. Padro et al.   SEMINARS IN IMMUNOLOGY

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Prevention of infection caused by immunosuppressive drugs in gastroenterology

(2013) Katarzyna Orlicka et al.   Therapeutic Advances in Chronic Disease

Substance P Affects Growth Factors in Pseudomonas aeruginosa–Infected Mouse Cornea

(2012) Megan E. B. Foldenauer et al.   CORNEA

Opiate Drug Use and the Pathophysiology of NeuroAIDS

(2012) Kurt F. Hauser et al.   CURRENT HIV RESEARCH

Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis

(2012) Gabriela Jusek et al.   IMMUNOBIOLOGY

TRPV1 Deletion Enhances Local Inflammation and Accelerates the Onset of Systemic Inflammatory Response Syndrome

(2012) E. S. Fernandes et al.   JOURNAL OF IMMUNOLOGY

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

The Role of Mast Cells in the Defence against Pathogens

(2012) Mirjam Urb et al.   PLoS Pathogens

Role and Relevance of Mast Cells in Fungal Infections

(2012) R. Saluja et al.   Frontiers in Immunology

Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation

(2012) Antonio Recchiuti et al.   Frontiers in Immunology

Epidemiology of HIV-Related Neuropathy: A Systematic Literature Review

(2011) Sabyasachi Ghosh et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Relevance of mast cell–nerve interactions in intestinal nociception

(2011) Sophie A. van Diest et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transcriptomic analyses of murine resolution-phase macrophages

(2011) M. J. Stables et al.   BLOOD

17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

(2011) S Bang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Toll-like receptor 2/MyD88 signaling mediates zymosan-induced joint hypernociception in mice: Participation of TNF-α, IL-1β and CXCL1/KC

(2011) Ana T.G. Guerrero et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

(2011) A. Diogenes et al.   JOURNAL OF DENTAL RESEARCH

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1

(2011) Liang Huang et al.   PAIN

Repeated Vulvovaginal Fungal Infections Cause Persistent Pain in a Mouse Model of Vulvodynia

(2011) M. A. Farmer et al.   Science Translational Medicine

Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2

(2010) Brian P. Tancowny et al.   IMMUNOLOGY

The impact of varicella zoster virus: Chronic pain

(2010) Wim Opstelten et al.   JOURNAL OF CLINICAL VIROLOGY

Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

(2010) Christine McCary et al.   JOURNAL OF NEUROIMMUNOLOGY

Dendritic Cells Transduced With Lentiviral Vectors Expressing VIP Differentiate Into VIP-secreting Tolerogenic-like DCs

(2010) Miguel G Toscano et al.   MOLECULAR THERAPY

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Substance P alters the in vitro LPS responsiveness of bovine monocytes and blood-derived macrophages

(2010) Anja Sipka et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Influence of Dendritic Cells on Viral Pathogenicity

(2009) Giulia Freer et al.   PLoS Pathogens

Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1

(2008) Alejo Chorny et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Morphological relationships between peptidergic nerve fibers and immunoglobulin A-producing lymphocytes in the mouse intestine

(2007) Maiko Shibata et al.   BRAIN BEHAVIOR AND IMMUNITY