GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis

METTL3 is required for maintaining β-cell function

(2021) Xinzhi Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

(2020) Yuqin Wang et al.   Nature Communications

Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes

(2020) Xinzhi Li et al.   MOLECULAR THERAPY

Purβ promotes hepatic glucose production by increasing Adcy6 transcription

(2019) Linna Jia et al.   Molecular Metabolism

C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice

(2018) Runping Liu et al.   HEPATOLOGY

Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity

(2018) José Carlos Santos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification and Functional Characterization of Long Non-coding RNA MIR22HG as a Tumor Suppressor for Hepatocellular Carcinoma

(2018) Dong-Yan Zhang et al.   Theranostics

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases

(2018) Yi Xiong et al.   eLife

A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury

(2017) Xiaomeng Ren et al.   FASEB JOURNAL

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

(2017) Alexander Wree et al.   HEPATOLOGY

Thymic NF-κB-inducing kinase regulates CD4 + T cell-elicited liver injury and fibrosis in mice

(2017) Hong Shen et al.   JOURNAL OF HEPATOLOGY

Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure

(2017) Benjamin L. Woolbright et al.   JOURNAL OF HEPATOLOGY

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

(2017) Peng Li et al.   NATURE

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

(2016) Christian Krapp et al.   Cell Host & Microbe

Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury

(2016) Francisco Javier Cubero et al.   GASTROENTEROLOGY

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease

(2016) Danielle Pilla-Moffett et al.   JOURNAL OF MOLECULAR BIOLOGY

A long non-coding RNA,APOA4-AS, regulatesAPOA4expression depending on HuR in mice

(2016) Wangshu Qin et al.   NUCLEIC ACIDS RESEARCH

Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses

(2015) Yang Liu et al.   JOURNAL OF HEPATOLOGY

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

(2015) Etienne Meunier et al.   NATURE IMMUNOLOGY

Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis

(2014) Hong Shen et al.   HEPATOLOGY

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

STAT1-Dependent Signal Integration between IFNγ and TLR4 in Vascular Cells Reflect Pro-Atherogenic Responses in Human Atherosclerosis

(2014) Stefan Chmielewski et al.   PLoS One

SH2B1 in  -Cells Regulates Glucose Metabolism by Promoting  -Cell Survival and Islet Expansion

(2013) Z. Chen et al.   DIABETES

Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses

(2012) Z. Chen et al.   DIABETES

Liver Regeneration Signature in Hepatitis B Virus (HBV)-Associated Acute Liver Failure Identified by Gene Expression Profiling

(2012) Oriel Nissim et al.   PLoS One

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

(2012) A. R. Shenoy et al.   SCIENCE

c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice

(2011) Sanda Win et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma

(2011) Edmund Kwok-Kwan Tung et al.   LIVER INTERNATIONAL

Hepatocyte Death: A Clear and Present Danger

(2010) Harmeet Malhi et al.   PHYSIOLOGICAL REVIEWS

Apoptosis as a Mechanism for Liver Disease Progression

(2010) Maria Eugenia Guicciardi et al.   SEMINARS IN LIVER DISEASE

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY