Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

(2021) Peng Xiao et al.   CELL

Structural insights into the human D1 and D2 dopamine receptor signaling complexes

(2021) Youwen Zhuang et al.   CELL

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

(2021) Fulai Zhou et al.   CELL RESEARCH

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling

(2021) Hadar Israeli et al.   SCIENCE

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

(2021) Ruben Sanchez-Garcia et al.   Communications Biology

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

(2020) Shanshan Ma et al.   MOLECULAR CELL

Structural basis of ligand recognition and self-activation of orphan GPR52

(2020) Xi Lin et al.   NATURE

Melanocortin 5 receptor signaling pathway in health and disease

(2020) Yahong Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

(2020) Kuglae Kim et al.   CELL

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Structure and dynamics of the active Gs-coupled human secretin receptor

(2020) Maoqing Dong et al.   Nature Communications

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

(2020) Jia Duan et al.   Nature Communications

Structural basis for activation of the growth hormone-releasing hormone receptor

(2020) Fulai Zhou et al.   Nature Communications

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment

(2019) Peter Kühnen et al.   TRENDS IN MOLECULAR MEDICINE

Alpha-melanocyte stimulating hormone in ghrelin-elicited feeding and gut motility

(2019) Hsien-Hao Huang et al.   Journal of the Chinese Medical Association

Assembly of a GPCR-G Protein Complex

(2019) Yang Du et al.   CELL

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

(2019) Luca A. Lotta et al.   CELL

The melanocortin pathway and control of appetite-progress and therapeutic implications

(2019) Giulia Baldini et al.   JOURNAL OF ENDOCRINOLOGY

Interaction between genes involved in energy intake regulation and diet in obesity

(2019) L. Crovesy et al.   NUTRITION

ACTH signalling and adrenal development: lessons from mouse models

(2019) Tatiana V Novoselova et al.   Endocrine Connections

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

The melanocortin-1 receptor reversely regulates the melanin synthesis and migration of melanoma cells via dimerization-induced conformational changes

(2019) Jisu Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The constitutive activity of melanocortin‐4 receptors in cAMP pathway is allosterically modulated by zinc and copper ions

(2019) Reet Link et al.   JOURNAL OF NEUROCHEMISTRY

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

(2018) Tristan Ian Croll   Acta Crystallographica Section D-Structural Biology

Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

(2018) Yanyong Kang et al.   NATURE

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

(2018) Yi-Lynn Liang et al.   NATURE

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

(2018) Yi-Lynn Liang et al.   NATURE

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

(2017) Yi-Lynn Liang et al.   NATURE

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

(2017) Yan Zhang et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?

(2017) Davids Fridmanis et al.   Frontiers in Endocrinology

The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer

(2016) Ping Liu et al.   ACTA PHARMACOLOGICA SINICA

60 YEARS OF POMC: Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides

(2016) Robert M Dores et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides

(2016) Niamh X Cawley et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Melanocortin 1 Receptor: Structure, Function, and Regulation

(2016) Erin M. Wolf Horrell et al.   Frontiers in Genetics

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Assessment of gene expression levels of proopiomelanocortin (POMC) and melanocortin-1 receptor (MC1R) in vitiligo

(2015) Noha A Nagui et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

An α-MSH Analog in Erythropoietic Protoporphyria

(2015) Thomas A. Luger et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A general protocol for the generation of Nanobodies for structural biology

(2014) Els Pardon et al.   Nature Protocols

Neural melanocortin receptors in obesity and related metabolic disorders

(2013) Clemence Girardet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Hypothalamic Control of Lipid Metabolism: Focus on Leptin, Ghrelin and Melanocortins

(2011) Carlos Diéguez et al.   NEUROENDOCRINOLOGY

Physiological factors that regulate skin pigmentation

(2009) Yuji Yamaguchi et al.   BIOFACTORS

Constitutive Expression of MC1R in HaCaT Keratinocytes Inhibits Basal and UVB-induced TNF-α Production

(2009) Geneviève Garcin et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY