Studying synapses in human brain with array tomography and electron microscopy

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Synaptic alterations in the rTg4510 mouse model of tauopathy

(2012) Katherine J. Kopeikina et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced NMDA Receptor-Dependent Thalamic Excitation and Network Oscillations in Stargazer Mice

(2012) C. J. Lacey et al.   JOURNAL OF NEUROSCIENCE

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease

(2012) Nikita Rudinskiy et al.   NATURE NEUROSCIENCE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Three-Dimensional, Tomographic Super-Resolution Fluorescence Imaging of Serially Sectioned Thick Samples

(2012) Siddharth Nanguneri et al.   PLoS One

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Quantitative analysis of glutamatergic innervation of the mouse dorsal raphe nucleus using array tomography

(2011) Mariano Soiza-Reilly et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Three-Dimensional Microstructural Changes in Murine Abdominal Aortic Aneurysms Quantified Using Immunofluorescent Array Tomography

(2011) Sanaz Saatchi et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis

(2011) Sabine Koch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Characterization of Genetically Targeted Neuron Types in the Zebrafish Optic Tectum

(2011) Estuardo Robles et al.   Frontiers in Neural Circuits

Synapse loss in dementias

(2010) Ryan Clare et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Single-Synapse Analysis of a Diverse Synapse Population: Proteomic Imaging Methods and Markers

(2010) Kristina D. Micheva et al.   NEURON

Synaptic Protection in the Brain of WldS Mice Occurs Independently of Age but Is Sensitive to Gene-Dose

(2010) Ann K. Wright et al.   PLoS One

High resolution three-dimensional reconstruction of the collagenous matrix of the human optic nerve head

(2009) Moritz Winkler et al.   BRAIN RESEARCH BULLETIN

Pseudoreplication is (still) a problem.

(2009) Todd M. Freeberg et al.   JOURNAL OF COMPARATIVE PSYCHOLOGY

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of recent methods for efficiently quantifying immunogold and other nanoparticles using TEM sections through cells, tissues and organs

(2008) Terry M. Mayhew et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON