Resident cardiac macrophages: Heterogeneity and function in health and disease

Long-term cardiovascular outcomes of COVID-19

(2022) Yan Xie et al.   NATURE MEDICINE

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

(2022) Sarah A. Dick et al.   Science Immunology

Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy

(2022) Xudong Liao et al.   JCI Insight

Single‐Cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction

(2022) Kaiyu Jin et al.   Small Methods

Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart

(2022) Hengwei Jin et al.   CIRCULATION RESEARCH

COVID-19–Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review

(2022) Raghed Almamlouk et al.   CLINICAL MICROBIOLOGY AND INFECTION

A cardioimmunologist’s toolkit: genetic tools to dissect immune cells in cardiac disease

(2022) Anthony Wong et al.   Nature Reviews Cardiology

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

(2022) Mark Chaffin et al.   NATURE

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies

(2022) Daniel Reichart et al.   SCIENCE

Cardiac macrophage density in Covid-19 infection: relationship to myocyte necrosis and acute lung injury

(2022) Husam Jum'ah et al.   CARDIOVASCULAR PATHOLOGY

Myocardial Inflammation and Dysfunction in COVID-19–Associated Myocardial Injury

(2021) Ludwig T. Weckbach et al.   Circulation-Cardiovascular Imaging

Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart

(2021) Thomas J. Cahill et al.   DEVELOPMENT

Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels

(2021) Ana Simon-Chica et al.   CARDIOVASCULAR RESEARCH

Cardiac macrophages prevent sudden death during heart stress

(2021) Junichi Sugita et al.   Nature Communications

Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury

(2021) Shi-Hao Ni et al.   CARDIOVASCULAR RESEARCH

Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress

(2021) Rysa Zaman et al.   IMMUNITY

Resident cardiac macrophages mediate adaptive myocardial remodeling

(2021) Nicole R. Wong et al.   IMMUNITY

Cardiac macrophage subsets differentially regulate lymphatic network remodeling during pressure overload

(2021) Mathilde Bizou et al.   Scientific Reports

Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis

(2021) Xavier S. Revelo et al.   CIRCULATION RESEARCH

Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung

(2020) Eniko Sajti et al.   NATURE IMMUNOLOGY

Transcriptional and Cellular Diversity of the Human Heart

(2020) Nathan R. Tucker et al.   CIRCULATION

Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis

(2020) Xiumeng Hua et al.   CIRCULATION

Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-induced Cardiomyopathy Through the SR-A1-c-Myc Axis

(2020) Hanwen Zhang et al.   CIRCULATION RESEARCH

Establishment and Maintenance of the Macrophage Niche

(2020) Martin Guilliams et al.   IMMUNITY

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

(2020) Masataka Nishiga et al.   Nature Reviews Cardiology

Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases

(2020) Diana Lindner et al.   JAMA Cardiology

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

(2020) José A. Nicolás-Ávila et al.   CELL

Cells of the adult human heart

(2020) Monika Litviňuková et al.   NATURE

The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages

(2020) David M. Calcagno et al.   Science Immunology

Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

(2020) Jonathan R. Brestoff et al.   Cell Metabolism

A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

(2020) Jung-Seok Kim et al.   IMMUNITY

Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium

(2020) Rysa Zaman et al.   CURRENT OPINION IN IMMUNOLOGY

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

(2019) Geetika Bajpai et al.   CIRCULATION RESEARCH

Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis

(2019) Atsushi Anzai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart

(2019) Yueli Cui et al.   Cell Reports

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

Endothelial cell–cardiomyocyte crosstalk in heart development and disease

(2019) Andrea Colliva et al.   JOURNAL OF PHYSIOLOGY-LONDON

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

(2019) Nona Farbehi et al.   eLife

Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis

(2019) Justin F. Deniset et al.   IMMUNITY

Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling

(2019) Zhaoning Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge

(2019) Friedrich Felix Hoyer et al.   IMMUNITY

Decoding human fetal liver haematopoiesis

(2019) Dorin-Mirel Popescu et al.   NATURE

A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart

(2019) Michaela Asp et al.   CELL

Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload–Driven Heart Failure Reveals Extent of Immune Activation

(2019) Elisa Martini et al.   CIRCULATION

The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction

(2018) Joaquim Miguel Vieira et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac macrophages promote diastolic dysfunction

(2018) Maarten Hulsmans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The human heart contains distinct macrophage subsets with divergent origins and functions

(2018) Geetika Bajpai et al.   NATURE MEDICINE

Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy

(2018) Xudong Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

(2018) Hwee Ying Lim et al.   IMMUNITY

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

(2018) Sarah A. Dick et al.   NATURE IMMUNOLOGY

Cardiac lymphatics in health and disease

(2018) Ebba Brakenhielm et al.   Nature Reviews Cardiology

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

(2018) Anat Shemer et al.   Nature Communications

Do patients have worse outcomes in heart failure than in cancer? A primary care-based cohort study with 10-year follow-up in Scotland

(2017) Mamas A. Mamas et al.   EUROPEAN JOURNAL OF HEART FAILURE

A CD103 + Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis

(2017) Xavier Clemente-Casares et al.   IMMUNITY

A heart–brain–kidney network controls adaptation to cardiac stress through tissue macrophage activation

(2017) Katsuhito Fujiu et al.   NATURE MEDICINE

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

Efferocytosis and Outside-In Signaling by Cardiac Phagocytes. Links to Repair, Cellular Programming, and Intercellular Crosstalk in Heart

(2017) Matthew DeBerge et al.   Frontiers in Immunology

Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration

(2016) Virpi Talman et al.   CELL AND TISSUE RESEARCH

Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial InfarctionCLINICAL PERSPECTIVE

(2016) Orianne Henri et al.   CIRCULATION

Primitive Embryonic Macrophages are Required for Coronary Development and MaturationNovelty and Significance

(2016) Jamison Leid et al.   CIRCULATION RESEARCH

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart FailureNovelty and Significance

(2016) Hendrik B. Sager et al.   CIRCULATION RESEARCH

Chronic Heart Failure and Inflammation

(2016) Sarah A. Dick et al.   CIRCULATION RESEARCH

α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart

(2016) Aleksandr Stotland et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heart Failure: Diagnosis, Management and Utilization

(2016) Arati Inamdar et al.   Journal of Clinical Medicine

Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells

(2015) Partha Dutta et al.   Cell Stem Cell

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis

(2015) Carolina Jaquenod De Giusti et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

(2014) Ingo Hilgendorf et al.   CIRCULATION RESEARCH

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

Silencing of CCR2 in myocarditis

(2014) Florian Leuschner et al.   EUROPEAN HEART JOURNAL

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Macrophages are required for neonatal heart regeneration

(2014) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac fibroblasts mediate IL-17A–driven inflammatory dilated cardiomyopathy

(2014) Lei Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-Investigator Letter on Reproducibility of Neonatal Heart Regeneration following Apical Resection

(2014) Hesham A. Sadek et al.   Stem Cell Reports

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile

(2012) Alexander R. Pinto et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Oncostatin M Is a Major Mediator of Cardiomyocyte Dedifferentiation and Remodeling

(2011) Thomas Kubin et al.   Cell Stem Cell

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function

(2010) Ranjeet M. Dongaonkar et al.   CARDIOVASCULAR RESEARCH

Impaired Infarct Healing in Atherosclerotic Mice With Ly-6ChiMonocytosis

(2010) Peter Panizzi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

(2009) Laurent Chorro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

(2008) Masako Kohyama et al.   NATURE