Endothelial cell–cardiomyocyte crosstalk in heart development and disease

Apelin and APJ orchestrate complex tissue-specific control of cardiomyocyte hypertrophy and contractility in the hypertrophy-heart failure transition

(2018) Victoria Nicole Parikh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The ontogeny, activation and function of the epicardium during heart development and regeneration

(2018) Filipa C. Simões et al.   DEVELOPMENT

The epicardium as a hub for heart regeneration

(2018) Jingli Cao et al.   Nature Reviews Cardiology

Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases

(2018) Yan Li et al.   Nature Reviews Cardiology

Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO

(2018) Vincent F. M. Segers et al.   Frontiers in Physiology

Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia

(2018) Tsering Stobdan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pilot Study of Endothelin Receptor Blockade in Heart Failure with Diastolic Dysfunction and Pulmonary Hypertension (BADDHY-Trial)

(2017) B. Koller et al.   Heart Lung and Circulation

Endothelial Mesenchymal Transition in Hypoxic Microvascular Endothelial Cells and Paracrine Induction of Cardiomyocyte Apoptosis Are Mediated via TGFβ1/SMAD Signaling

(2017) Isabella Sniegon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coculturing with endothelial cells promotes in vitro maturation and electrical coupling of human embryonic stem cell–derived cardiomyocytes

(2017) Jennifer Pasquier et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

In vitro models of the cardiac microenvironment to study myocyte and non-myocyte crosstalk: bioinspired approaches beyond the polystyrene dish

(2017) Celinda M. Kofron et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome

(2017) Jiani C. Yin et al.   Nature Communications

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

(2017) Rahul Rai et al.   Cell Reports

Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and DysfunctionNovelty and Significance

(2016) Lin Zhao et al.   CIRCULATION RESEARCH

Hypoxia-induced endothelial-mesenchymal transition is associated with RASAL1 promoter hypermethylation in human coronary endothelial cells

(2016) Xingbo Xu et al.   FEBS LETTERS

Thioredoxin Uses a GSH-independent Route to Deglutathionylate Endothelial Nitric-oxide Synthase and Protect against Myocardial Infarction

(2016) Jaganathan Subramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast revascularization of the injured area is essential to support zebrafish heart regeneration

(2016) Rubén Marín-Juez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

(2016) Stephanie M. Ravenscroft et al.   TOXICOLOGICAL SCIENCES

Notch-independent RBPJ controls angiogenesis in the adult heart

(2016) Ramón Díaz-Trelles et al.   Nature Communications

Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes MellitusSignificance

(2015) Amy Pei-Ling Chiu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes

(2015) Nahuel A. Garcia et al.   CARDIOVASCULAR RESEARCH

Endothelial Cells Regulate Cardiac Myocyte Reorganisation Through β1-Integrin Signalling

(2015) Yu Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Functional Recovery of a Human Neonatal Heart After Severe Myocardial InfarctionNovelty and Significance

(2015) Bernhard J. Haubner et al.   CIRCULATION RESEARCH

Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension

(2015) Germán E. González et al.   JOURNAL OF HYPERTENSION

Endothelin-1 upregulation mediates aging-related cardiac fibrosis

(2015) Xianwei Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endothelial Cells Control Pancreatic Cell Fate at Defined Stages through EGFL7 Signaling

(2015) Der-I Kao et al.   Stem Cell Reports

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Physiological regulation of lipoprotein lipase

(2014) Sander Kersten   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

(2014) H. I. Chen et al.   DEVELOPMENT

Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells

(2014) Xiaohong Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Vascular Endothelial Growth Factor-B in Physiology and Disease

(2014) Maija Bry et al.   PHYSIOLOGICAL REVIEWS

Vascular Endothelium Derived Endothelin-1 Is Required for Normal Heart Function after Chronic Pressure Overload in Mice

(2014) Susi Heiden et al.   PLoS One

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy

(2014) K. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-Investigator Letter on Reproducibility of Neonatal Heart Regeneration following Apical Resection

(2014) Hesham A. Sadek et al.   Stem Cell Reports

Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes

(2013) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca2+ in adult cardiac myocytes

(2013) Clémence Merlen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Impairment of Endothelial-Myocardial Interaction Increases the Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury

(2013) Thorsten M. Leucker et al.   PLoS One

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

Functional 3-D cardiac co-culture model using bioactive chitosan nanofiber scaffolds

(2012) Ali Hussain et al.   BIOTECHNOLOGY AND BIOENGINEERING

Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling

(2012) Bingruo Wu et al.   CELL

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

(2012) Carolina E. Hagberg et al.   NATURE

APJ acts as a dual receptor in cardiac hypertrophy

(2012) Maria Cecilia Scimia et al.   NATURE

Matricellular Proteins in Cardiac Adaptation and Disease

(2012) Nikolaos G. Frangogiannis   PHYSIOLOGICAL REVIEWS

Characterization of potential S-nitrosylation sites in the myocardium

(2011) Mark J. Kohr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Therapeutic angiogenesis for myocardial ischemia revisited: basic biological concepts and focus on latest clinical trials

(2011) Sofoclis Mitsos et al.   ANGIOGENESIS

The ATP-Binding Cassette Transporter ABCG2 Protects Against Pressure Overload–Induced Cardiac Hypertrophy and Heart Failure by Promoting Angiogenesis and Antioxidant Response

(2011) Yasutomi Higashikuni et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism

(2011) Federica Accornero et al.   CIRCULATION RESEARCH

Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

(2011) Nathaniel L. Tulloch et al.   CIRCULATION RESEARCH

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy

(2010) Katrien Lemmens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cell Communications in the Heart

(2010) Daniela Tirziu et al.   CIRCULATION

Triglyceride lipases and atherosclerosis

(2010) Gunilla Olivecrona et al.   CURRENT OPINION IN LIPIDOLOGY

DIP2A Functions as a FSTL1 Receptor

(2010) Noriyuki Ouchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronary arteries form by developmental reprogramming of venous cells

(2010) Kristy Red-Horse et al.   NATURE

Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid

(2009) Fang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction

(2009) Lorena Zentilin et al.   FASEB JOURNAL

Targeting angiogenesis to restore the microcirculation after reperfused MI

(2009) Anja M. van der Laan et al.   Nature Reviews Cardiology

Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue

(2009) K. R. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thyroid hormone and angiogenesis

(2009) Mary K. Luidens et al.   VASCULAR PHARMACOLOGY

Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus

(2008) Naoto Sasaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cell Coculture Within Tissue-Engineered Cardiomyocyte Sheets Enhances Neovascularization and Improves Cardiac Function of Ischemic Hearts

(2008) H. Sekine et al.   CIRCULATION