Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

(2018) James C. Cronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K + Channel THIK-1

(2018) Christian Madry et al.   NEURON

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

(2018) C. Stremmel et al.   Nature Communications

Hematopoietic Gene Therapies for Metabolic and Neurologic Diseases

(2017) Alessandra Biffi   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Genetic Barcodes Facilitate Competitive Clonal Analyses In Vivo

(2017) Tim Aranyossy et al.   HUMAN GENE THERAPY

Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

(2017) Diana Varol et al.   IMMUNITY

Protective and Pathological Immunity during Central Nervous System Infections

(2017) Robyn S. Klein et al.   IMMUNITY

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

(2017) Kazuyuki Takata et al.   IMMUNITY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C − Cells

(2017) Alexander Mildner et al.   IMMUNITY

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

(2017) Tuan Leng Tay et al.   NATURE NEUROSCIENCE

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

(2017) Rosa C. Paolicelli et al.   NEURON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Limitations and challenges of genetic barcode quantification

(2017) Lars Thielecke et al.   Scientific Reports

Microglia in Alzheimer’s disease: A multifaceted relationship

(2016) Ayman ElAli et al.   BRAIN BEHAVIOR AND IMMUNITY

P2Y12receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases

(2016) Alexander Mildner et al.   GLIA

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Sall1 is a transcriptional regulator defining microglia identity and function

(2016) Anne Buttgereit et al.   NATURE IMMUNOLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Neuronal morphometry directly from bitmap images

(2014) Tiago A Ferreira et al.   NATURE METHODS

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

(2014) D. A. Jaitin et al.   SCIENCE

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Busulfan Conditioning Enhances Engraftment of Hematopoietic Donor-derived Cells in the Brain Compared With Irradiation

(2013) Fiona L Wilkinson et al.   MOLECULAR THERAPY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Bone Marrow Cell Recruitment to the Brain in the Absence of Irradiation or Parabiosis Bias

(2013) Katrin Kierdorf et al.   PLoS One

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

(2013) A. Biffi et al.   SCIENCE

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation

(2012) A. Capotondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Simple Neurite Tracer: open source software for reconstruction, visualization and analysis of neuronal processes

(2011) M. H. Longair et al.   BIOINFORMATICS

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY