Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies
Authors
Keywords
-
Journal
SCIENCE
Volume 377, Issue 6606, Pages -
Publisher
American Association for the Advancement of Science (AAAS)
Online
2022-08-05
DOI
10.1126/science.abo1984
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Probabilistic harmonization and annotation of single‐cell transcriptomics data with deep generative models
- (2021) Chenling Xu et al. Molecular Systems Biology
- Transcriptomic Coupling of PKP2 With Inflammatory and Immune Pathways Endogenous to Adult Cardiac Myocytes
- (2021) Marta Pérez-Hernández et al. Frontiers in Physiology
- Inference and analysis of cell-cell communication using CellChat
- (2021) Suoqin Jin et al. Nature Communications
- Consensus Transcriptional Landscape of Human End‐Stage Heart Failure
- (2021) Ricardo O. Ramirez Flores et al. Journal of the American Heart Association
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Lmna Mutation
- (2021) Kenji Onoue et al. Frontiers in Cardiovascular Medicine
- Angiotensin II receptor type 1 – An update on structure, expression and pathology
- (2021) Robert Eckenstaler et al. BIOCHEMICAL PHARMACOLOGY
- Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy
- (2021) Luis Escobar-Lopez et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis
- (2020) Marc Mejias et al. GASTROENTEROLOGY
- The mutational constraint spectrum quantified from variation in 141,456 humans
- (2020) Konrad J. Karczewski et al. NATURE
- PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function
- (2020) Yuanyuan Wang et al. Scientific Reports
- Solo: Doublet Identification in Single-Cell RNA-Seq via Semi-Supervised Deep Learning
- (2020) Nicholas J. Bernstein et al. Cell Systems
- SLIT3 deficiency attenuates pressure overload–induced cardiac fibrosis and remodeling
- (2020) Lianghui Gong et al. JCI Insight
- Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion
- (2020) Yabo Fang et al. Frontiers in Cell and Developmental Biology
- The Human Explanted Heart Program: A Translational Bridge for Cardiovascular Medicine
- (2020) Hao Zhang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mechanical circulatory support does not reduce advanced myocardial fibrosis in patients with terminal heart failure
- (2020) Astrid Kassner et al. EUROPEAN JOURNAL OF HEART FAILURE
- Cells of the adult human heart
- (2020) Monika Litviňuková et al. NATURE
- Genetic and functional insights into the fractal structure of the heart
- (2020) Hannah V. Meyer et al. NATURE
- LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
- (2020) Changyoun Kim et al. Science Translational Medicine
- A molecular cell atlas of the human lung from single-cell RNA sequencing
- (2020) Kyle J. Travaglini et al. NATURE
- Beta 1 -Adrenergic Receptor Regulation Revisited
- (2019) Susan F. Steinberg CIRCULATION RESEARCH
- The N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics
- (2019) Yang Li et al. JOURNAL OF CELL SCIENCE
- Microvascular Dysfunction in Dilated Cardiomyopathy
- (2019) Ankur Gulati et al. JACC-Cardiovascular Imaging
- The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes
- (2019) Chandramohan Chitraju et al. JOURNAL OF LIPID RESEARCH
- Molecular mechanisms of arrhythmogenic cardiomyopathy
- (2019) Karyn M. Austin et al. Nature Reviews Cardiology
- g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
- (2019) Uku Raudvere et al. NUCLEIC ACIDS RESEARCH
- Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data
- (2019) Samuel L. Wolock et al. Cell Systems
- Cardioprotective Effects of MTSS1 Enhancer Variants
- (2019) Michael P. Morley et al. CIRCULATION
- Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex
- (2019) Kuang Shen et al. CELL
- Mechanisms of the Multitasking Endothelial Protein NRG-1 as a Compensatory Factor During Chronic Heart Failure
- (2019) Gilles W. De Keulenaer et al. Circulation-Heart Failure
- Fast, sensitive and accurate integration of single-cell data with Harmony
- (2019) Ilya Korsunsky et al. NATURE METHODS
- Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult HeartNovelty and Significance
- (2018) Juan Tang et al. CIRCULATION RESEARCH
- Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development
- (2018) Yang Xiao et al. DEVELOPMENTAL CELL
- Methamphetamine exposure triggers apoptosis and autophagy in neuronal cells by activating the C/EBPβ-related signaling pathway
- (2018) Xiang Xu et al. FASEB JOURNAL
- Proteoglycans in brain development and pathogenesis
- (2018) Nancy B. Schwartz et al. FEBS LETTERS
- CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation
- (2018) Nicola Whiffin et al. GENETICS IN MEDICINE
- Role of integrin alpha8 in murine model of lung fibrosis
- (2018) Chi F. Hung et al. PLoS One
- Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy
- (2018) Xudong Liao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulatory Role of CD4+ T Cells in Myocarditis
- (2018) Daria Vdovenko et al. Journal of Immunology Research
- Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation
- (2018) Gonzalo del Monte-Nieto et al. NATURE
- Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart
- (2018) Junco S. Warren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction
- (2018) Sarah A. Dick et al. NATURE IMMUNOLOGY
- Ensembl 2019
- (2018) Fiona Cunningham et al. NUCLEIC ACIDS RESEARCH
- Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes
- (2017) Roddy Walsh et al. EUROPEAN HEART JOURNAL
- Geometric Deep Learning: Going beyond Euclidean data
- (2017) Michael M. Bronstein et al. IEEE SIGNAL PROCESSING MAGAZINE
- IL11 is a crucial determinant of cardiovascular fibrosis
- (2017) Sebastian Schafer et al. NATURE
- Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT SyndromeCLINICAL PERSPECTIVE
- (2017) Leigh Anne Swayne et al. Circulation-Cardiovascular Genetics
- Molecular Basis of ABHD5 Lipolysis Activation
- (2017) Matthew A. Sanders et al. Scientific Reports
- GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals
- (2017) Raúl Méndez-Giráldez et al. Scientific Reports
- Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury
- (2016) Stacey L. House et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The chromatin-binding protein Smyd1 restricts adult mammalian heart growth
- (2016) Sarah Franklin et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Silencing of CD40 in vivo reduces progression of experimental atherogenesis through an NF-κB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis
- (2016) Miguel Hueso et al. ATHEROSCLEROSIS
- TECRL , a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT
- (2016) Harsha D Devalla et al. EMBO Molecular Medicine
- The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size
- (2016) Alex Hørby Christensen et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization
- (2016) Guangchuang Yu et al. Molecular BioSystems
- Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models
- (2016) Vahri Beaumont et al. NEURON
- “Decoding” Angiogenesis: New Facets Controlling Endothelial Cell Behavior
- (2016) Raj Sewduth et al. Frontiers in Physiology
- Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover
- (2016) Ines Marek et al. PLoS One
- Endocardial Fibroelastosis Is Caused by Aberrant Endothelial to Mesenchymal Transition
- (2015) X. Xu et al. CIRCULATION RESEARCH
- Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology
- (2015) Sue Richards et al. GENETICS IN MEDICINE
- Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization
- (2015) Joanne Tonkin et al. MOLECULAR THERAPY
- Targeting BMP signalling in cardiovascular disease and anaemia
- (2015) Nicholas W. Morrell et al. Nature Reviews Cardiology
- Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade
- (2015) Catherine K. Hathaway et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn
- (2015) Hisashi Hasumi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation
- (2015) Sumeda Nandadasa et al. Cell Reports
- Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation
- (2014) Yukiko Hasumi et al. HUMAN MOLECULAR GENETICS
- The role of glypicans in Hedgehog signaling
- (2014) Jorge Filmus et al. MATRIX BIOLOGY
- Bayesian-multiplicative treatment of count zeros in compositional data sets
- (2014) Josep-Antoni Martín-Fernández et al. STATISTICAL MODELLING
- Control of inflammatory heart disease by CD4+T cells
- (2013) Jobert G. Barin et al. Annals of the New York Academy of Sciences
- The pathogenesis of cardiac fibrosis
- (2013) Ping Kong et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis
- (2013) Jessica J. Connelly et al. HUMAN MOLECULAR GENETICS
- dbNSFP v2.0: A Database of Human Non-synonymous SNVs and Their Functional Predictions and Annotations
- (2013) Xiaoming Liu et al. HUMAN MUTATION
- Differences in phosphodiesterase 3A and 3B expression after ischemic insult
- (2013) Yumiko Mitome-Mishima et al. NEUROSCIENCE RESEARCH
- Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload
- (2012) Catalin F. Baicu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Calmodulin-Dependent Protein Kinase II: Linking Heart Failure and Arrhythmias
- (2012) Paari Dominic Swaminathan et al. CIRCULATION RESEARCH
- Neuregulin in Cardiovascular Development and Disease
- (2012) Oghenerukevwe Odiete et al. CIRCULATION RESEARCH
- G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase
- (2012) Martina Schweiger et al. JOURNAL OF LIPID RESEARCH
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation
- (2012) Davis J. McCarthy et al. NUCLEIC ACIDS RESEARCH
- Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase
- (2011) Alex C.Y. Chang et al. DEVELOPMENTAL CELL
- Sh3rf2/POSHER Protein Promotes Cell Survival by Ring-mediated Proteasomal Degradation of the c-Jun N-terminal Kinase Scaffold POSH (Plentyof SH3s) Protein
- (2011) Michael Wilhelm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-clustered protocadherin
- (2011) Soo-Young Kim et al. Cell Adhesion & Migration
- ADAMTS9 Is a Cell-Autonomously Acting, Anti-Angiogenic Metalloprotease Expressed by Microvascular Endothelial Cells
- (2010) Bon-Hun Koo et al. AMERICAN JOURNAL OF PATHOLOGY
- DeathBase: a database on structure, evolution and function of proteins involved in apoptosis and other forms of cell death
- (2010) J Díez et al. CELL DEATH AND DIFFERENTIATION
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
- (2010) A. McKenna et al. GENOME RESEARCH
- Epidemiology and risk profile of heart failure
- (2010) Anh L. Bui et al. Nature Reviews Cardiology
- Galanin Receptor 1 Deletion Exacerbates Hippocampal Neuronal Loss after Systemic Kainate Administration in Mice
- (2010) P. Elyse Schauwecker PLoS One
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- Globally optimal stitching of tiled 3D microscopic image acquisitions
- (2009) S. Preibisch et al. BIOINFORMATICS
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Folate Receptor Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages
- (2009) A. Puig-Kroger et al. CANCER RESEARCH
- Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
- (2009) Norifumi Takeda et al. JOURNAL OF CLINICAL INVESTIGATION
- The HLA genomic loci map: expression, interaction, diversity and disease
- (2009) Takashi Shiina et al. JOURNAL OF HUMAN GENETICS
- Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells
- (2008) Shaobo Jin et al. CIRCULATION RESEARCH
- Periostin regulates atrioventricular valve maturation
- (2008) Russell A. Norris et al. DEVELOPMENTAL BIOLOGY
- Deficiency ofMyo18Bin mice results in embryonic lethality with cardiac myofibrillar aberrations
- (2008) Rieko Ajima et al. GENES TO CELLS
- Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines
- (2008) Hidenori Itabashi et al. HEPATOLOGY RESEARCH
- Fast unfolding of communities in large networks
- (2008) Vincent D Blondel et al. JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now