Inhibition of the glycogen synthase kinase 3β–hypoxia‐inducible factor 1α pathway alleviates NLRP3‐mediated pyroptosis induced by high glucose in renal tubular epithelial cells

GSK-3β-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts

(2022) Shu-Hui Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

FGF1ΔHBS delays the progression of diabetic nephropathy in late-stage type 2 diabetes mouse model by alleviating renal inflammation, fibrosis, and apoptosis

(2022) Qian Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

(2021) Xiaomeng Feng et al.   Frontiers in Endocrinology

HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia

(2021) Dong Yuan et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway

(2021) Ying Wen et al.   PHYTOMEDICINE

Novel Effects of Combination Therapy Through Inhibition of Caspase-1/Gasdermin D Induced-Pyroptosis in Lupus Nephritis

(2021) Heng Cao et al.   Frontiers in Immunology

Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKT/GSK3 β/β-Catenin Pathway by Restoring Autophagic Activity

(2020) Yimin Shi et al.   Evidence-based Complementary and Alternative Medicine

Silencing of KCNQ1OT1 Decreases Oxidative Stress and Pyroptosis of Renal Tubular Epithelial Cells

(2020) Bei Zhu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

GSK-3β in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer

(2020) Jintao Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanism and regulation of pyroptosis-mediated in cancer cell death

(2020) Jianwei Ruan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

LncRNA MALAT1 promoted high glucose‐induced pyroptosis of renal tubular epithelial cell by sponging miR ‐30c targeting for NLRP3

(2020) Chan Liu et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study

(2020) Yongze Li et al.   BMJ-British Medical Journal

Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β

(2020) Haixiao Liu et al.   EXPERIMENTAL NEUROLOGY

Focus on the Role of NLRP3 Inflammasome in Diseases

(2020) Roberta Fusco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1

(2020) Yong Yang et al.   Frontiers in Pharmacology

Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via NF-κB Signaling

(2020) Chengcheng Xiao et al.   Frontiers in Physiology

New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

(2020) Jinwen Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis alleviates excess molybdenum-induced apoptosis in duck renal tubular epithelial cells

(2020) Shaoxing Pi et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Glycogen synthase kinase-3β inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction

(2020) Shuhui Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

LncRNA-antisense non-coding RNA in the INK4 locus promotes pyroptosis via miR-497/thioredoxin-interacting protein axis in diabetic nephropathy

(2020) Jia Wang et al.   LIFE SCIENCES

Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis

(2019) Li Zhang et al.   Oxidative Medicine and Cellular Longevity

Inhibition of Caspase-1-dependent pyroptosis attenuates copper-induced apoptosis in chicken hepatocytes

(2019) Jianzhao Liao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease

(2019) Youliang Wang et al.   Frontiers in Endocrinology

Pro-inflammatory cytokines are associated with podocyte damage and proximal tubular dysfunction in the early stage of diabetic kidney disease in type 2 diabetes mellitus patients

(2019) Oana Milas et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

The Signaling of Cellular Senescence in Diabetic Nephropathy

(2019) Yabing Xiong et al.   Oxidative Medicine and Cellular Longevity

Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury

(2019) Changhui Diao et al.   Oxidative Medicine and Cellular Longevity

Diabetic Retinopathy: Pathophysiology and Treatments

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deficiency of hypoxia inducible factor‑1α promoted progression of diabetic nephropathy with hypertension

(2018) Yuejiang Jiao et al.   Experimental and Therapeutic Medicine

Role of pyroptosis in cardiovascular diseases

(2018) Chang Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosis

(2017) Yuanjun Guo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice

(2017) Theun de Groot et al.   PLoS One

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy

(2017) Hong Yi et al.   Cell Death & Disease

Hypoxic inactivation of glycogen synthase kinase-3β promotes gastric tumor growth and angiogenesis by facilitating hypoxia-inducible factor-1 signaling

(2016) Young San Ko et al.   APMIS

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

Asiatic Acid Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β/HIF-1α Signaling in Rat H9c2 Cardiomyocytes

(2016) Xiang Huang et al.   MOLECULES

Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway

(2015) Guoguo Shang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus

(2015) T. de Groot et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY