Novel Effects of Combination Therapy Through Inhibition of Caspase-1/Gasdermin D Induced-Pyroptosis in Lupus Nephritis

Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo

(2020) Zhuang Wang et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

Gasdermin D modulates murine lupus and its associated organ damage.

(2020) Xinghao Wang et al.   Arthritis & Rheumatology

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

(2020) Rosalie Heilig et al.   Life Science Alliance

New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

(2020) Jinwen Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synaptopodin Is Dispensable for Normal Podocyte Homeostasis but Is Protective in the Context of Acute Podocyte Injury

(2020) Liang Ning et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-Cell RNA Profiling of Glomerular Cells Shows Dynamic Changes in Experimental Diabetic Kidney Disease

(2019) Jia Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation

(2019) Chaohuan Guo et al.   JOURNAL OF AUTOIMMUNITY

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

(2019) Sheng Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancer of zeste homolog 2 modulates oxidative stress‐mediated pyroptosis in vitro and in a mouse kidney ischemia‐reperfusion injury model

(2019) Hao Liu et al.   FASEB JOURNAL

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

(2018) Elena Khanova et al.   HEPATOLOGY

Transcriptomic analysis uncovers novel synergistic mechanisms in combination therapy for lupus nephritis

(2018) Jia Fu et al.   KIDNEY INTERNATIONAL

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

(2018) Zhen Zhang et al.   Cell Death & Disease

Multitarget Therapy for Maintenance Treatment of Lupus Nephritis

(2017) Haitao Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lupus nephritis: NLRP3 inflammasome ignites podocyte dysfunction

(2017) Dario Ummarino   Nature Reviews Rheumatology

Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis

(2017) Rong Fu et al.   Arthritis & Rheumatology

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy

(2016) K. Shahzad et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multitarget Therapy for Induction Treatment of Lupus Nephritis

(2015) Zhihong Liu et al.   ANNALS OF INTERNAL MEDICINE

Lupus Nephritis: Glycogen Synthase Kinase 3β Promotion of Renal Damage Through Activation of the NLRP3 Inflammasome in Lupus-Prone Mice

(2015) Jijun Zhao et al.   Arthritis & Rheumatology

NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling

(2014) Maciej Lech et al.   ANNALS OF THE RHEUMATIC DISEASES

P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

(2013) Jijun Zhao et al.   ARTHRITIS AND RHEUMATISM

An Essential Role of Caspase 1 in the Induction of Murine Lupus and Its Associated Vascular Damage

(2013) J. Michelle Kahlenberg et al.   Arthritis & Rheumatology

Lupus nephritis: current update

(2011) Ramesh Saxena et al.   ARTHRITIS RESEARCH & THERAPY

Successful Treatment of Class V+IV Lupus Nephritis with Multitarget Therapy

(2008) H. Bao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Value of a Complete or Partial Remission in Severe Lupus Nephritis

(2007) Y. E. Chen et al.   Clinical Journal of the American Society of Nephrology