Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury

Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro

(2019) Dongping Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

(2019) Naijun Miao et al.   KIDNEY INTERNATIONAL

Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis

(2019) Zahra Tavakoli Dargani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

VEGF mitigates histone-induced pyroptosis in the remote liver injury associated with renal allograft ischemia-reperfusion injury in rats

(2018) Hailin Zhao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Diosmetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury through Activating the Nrf2 Pathway and Inhibiting the NLRP3 Inflammasome

(2018) Qinmei Liu et al.   Biomolecules & Therapeutics

Anti-Inflammatory Effects of Vardenafil Against Cholestatic Liver Damage in Mice: a Mechanistic Study

(2018) Dina S. El-Agamy et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Artesunate Inhibits Renal Ischemia-Reperfusion-Mediated Remote Lung Inflammation Through Attenuating ROS-Induced Activation of NLRP3 Inflammasome

(2018) Zhaohui Liu et al.   INFLAMMATION

Zinc mitigates renal ischemia-reperfusion injury in rats by modulating oxidative stress, endoplasmic reticulum stress, and autophagy

(2018) Najet Hadj Abdallah et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of Calcium Sensing Receptor in Streptozotocin-Induced Diabetic Rats Exposed to Renal Ischemia Reperfusion Injury

(2018) Bo Hu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

PRMT5-mediated regulation of developmental myelination

(2018) Antonella Scaglione et al.   Nature Communications

Ischemic Preconditioning Promotes Autophagy and Alleviates Renal Ischemia/Reperfusion Injury

(2018) Ying Xie et al.   Biomed Research International

A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury

(2018) Jan R. Thiele et al.   Frontiers in Immunology

PRMT5 inhibition promotes osteogenic differentiation of mesenchymal stromal cells and represses basal interferon stimulated gene expression

(2018) Satya K. Kota et al.   BONE

Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells

(2018) Shan Song et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes

(2018) Pierre-Jacques Hamard et al.   Cell Reports

Brahma-related gene 1 ameliorates the neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation through activation of Nrf2/HO-1 signaling

(2018) Feng Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Chicoric acid alleviates lipopolysaccharide-induced acute lung injury in mice through anti-inflammatory and anti-oxidant activities

(2018) Hui Ding et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury

(2018) Su-Mi Kim et al.   Frontiers in Immunology

The Nrf2/HO-1 Pathway Mediates the Antagonist Effect of L-Arginine On Renal Ischemia/Reperfusion Injury in Rats

(2017) Fei Tong et al.   KIDNEY & BLOOD PRESSURE RESEARCH

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Zhen Qiu et al.   Oxidative Medicine and Cellular Longevity

Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation

(2017) Yimeng Zhang et al.   TOXICOLOGY

MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress

(2017) Xiao-Peng Yuan et al.   Oncotarget

Pore formation by GSDMD is the effector mechanism of pyroptosis

(2016) Moritz M Gaidt et al.   EMBO JOURNAL

Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity

(2016) Qian Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis

(2016) Dongying Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study

(2016) Ravindra L Mehta et al.   LANCET

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

(2016) Qing-Bing Zha et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction after Lung Transplantation

(2015) David M. Sayah et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Autophagy activation attenuates renal ischemia-reperfusion injury in rats

(2015) Ya-Li Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy

(2015) Ya-Ping Chang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia

(2015) Xiaoyong Tong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of Genetic Alterations in theNLRP3andCARD8Genes in Health and Disease

(2015) G. V. Paramel et al.   MEDIATORS OF INFLAMMATION

Arginine increases development of in vitro-produced porcine embryos and affects the protein arginine methyltransferase–dimethylarginine dimethylaminohydrolase–nitric oxide axis

(2015) Bethany K. Redel et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury

(2015) Tatsuki Matsumoto et al.   PLoS One

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome

(2014) Tiffany Horng   TRENDS IN IMMUNOLOGY

Anticancer Drug 2-Methoxyestradiol Protects against Renal Ischemia/Reperfusion Injury by Reducing Inflammatory Cytokines Expression

(2014) Ying-Yin Chen et al.   Biomed Research International

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

Activation of PRMT1 and PRMT5 mediates hypoxia- and ischemia-induced apoptosis in human lung epithelial cells and the lung of miniature pigs: The role of p38 and JNK mitogen-activated protein kinases

(2013) Seul Ki Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia–reperfusion injury in vivo and in vitro

(2013) Bin Peng et al.   BRAIN RESEARCH

Trans-2-phenylcyclopropylamine regulates zebrafish lateral line neuromast development mediated by depression of LSD1 activity

(2013) Yingzi He et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Epidermal Stem Cells and Their Epigenetic Regulation

(2013) Qi Shen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Synchronous Recruitment of Epigenetic Modifiers to Endotoxin Synergistically Activated Tnf-α Gene in Acute Kidney Injury

(2013) Karol Bomsztyk et al.   PLoS One

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade

(2012) Tong-You W. Wei et al.   CANCER SCIENCE

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Role of Nox4 in murine models of kidney disease

(2012) Andrea Babelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

(2011) Tin Oo Khor et al.   BIOCHEMICAL PHARMACOLOGY

Novel Aspects of Pharmacological Therapies for Acute Renal Failure

(2010) Ulrich Kunzendorf et al.   DRUGS

Targeted Deletion of Dicer from Proximal Tubules Protects against Renal Ischemia-Reperfusion Injury

(2010) Q. Wei et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants

(2010) Kyeong-Ah Jung et al.   MOLECULES

From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases

(2009) Dariusz Zakrzewicz et al.   BMC Pulmonary Medicine