Diabetic Retinopathy: Pathophysiology and Treatments

Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial

(2017) Sobha Sivaprasad et al.   LANCET

Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review

(2017) Laura N. Distefano et al.   Journal of Ophthalmology

Early and Long-Term Responses to Anti–Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema: Analysis of Protocol I Data

(2016) Victor H. Gonzalez et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Plasma E-selectin levels can play a role in the development of diabetic retinopathy

(2016) Márta Kasza et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy

(2016) Francesco Saverio Sorrentino et al.   LIFE SCIENCES

Intravitreal Aflibercept for Diabetic Macular Edema

(2016) Jeffrey S. Heier et al.   OPHTHALMOLOGY

Enhanced Benefit in Diabetic Macular Edema from AKB-9778 Tie2 Activation Combined with Vascular Endothelial Growth Factor Suppression

(2016) Peter A. Campochiaro et al.   OPHTHALMOLOGY

Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema

(2016) John A. Wells et al.   OPHTHALMOLOGY

Lipoprotein-associated phospholipase A2(Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes

(2016) Paul Canning et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

(2016) Elliott H. Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory

(2016) Pedro Romero-Aroca et al.   Journal of Diabetes Research

Topical Squalamine 0.2% and Intravitreal Ranibizumab 0.5 mg as Combination Therapy for Macular Edema Due to Branch and Central Retinal Vein Occlusion: An Open-Label, Randomized Study

(2016) John J. Wroblewski et al.   Ophthalmic Surgery Lasers & Imaging Retina

Effects of alpha-lipoic acid on retinal ganglion cells, retinal thicknesses, and VEGF production in an experimental model of diabetes

(2016) Emrah Kan et al.   INTERNATIONAL OPHTHALMOLOGY

A mitochondrial therapeutic reverses visual decline in mouse models of diabetes

(2015) N. M. Alam et al.   Disease Models & Mechanisms

Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy

(2015) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, in Diabetic Macular Edema

(2015) Giovanni Staurenghi et al.   OPHTHALMOLOGY

Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition

(2014) Hu Huang et al.   DIABETES

Effect of the Administration of Alpha-Lipoic Acid on Contrast Sensitivity in Patients with Type 1 and Type 2 Diabetes

(2014) Anna Gębka et al.   MEDIATORS OF INFLAMMATION

Three-Year, Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Diabetic Macular Edema

(2014) David S. Boyer et al.   OPHTHALMOLOGY

Chemokine Mediated Monocyte Trafficking into the Retina: Role of Inflammation in Alteration of the Blood-Retinal Barrier in Diabetic Retinopathy

(2014) Sampathkumar Rangasamy et al.   PLoS One

Role of phospholipases A2 in diabetic retinopathy: In vitro and in vivo studies

(2013) Gabriella Lupo et al.   BIOCHEMICAL PHARMACOLOGY

Subthreshold Laser Therapy for Diabetic Macular Edema: Metabolic and Safety Issues

(2013) Stela Vujosevic et al.   CURRENT MEDICINAL CHEMISTRY

Pericyte Loss in Diabetic Retinopathy: Mechanisms and Consequences

(2013) Elena Beltramo et al.   CURRENT MEDICINAL CHEMISTRY

Targeted deletion of Vegfa in adult mice induces vision loss

(2012) Toshihide Kurihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Intervention With an Erythropoietin-Derived Peptide Protects Against Neuroglial and Vascular Degeneration During Diabetic Retinopathy

(2011) Carmel M. McVicar et al.   DIABETES

Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion

(2011) Yukihiko Suzuki et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

A Phase 2/3, Multicenter, Randomized, Double-Masked, 2-Year Trial of Pegaptanib Sodium for the Treatment of Diabetic Macular Edema

(2011) Marla B. Sultan et al.   OPHTHALMOLOGY

Fluocinolone Acetonide Intravitreal Implant for Diabetic Macular Edema: A 3-Year Multicenter, Randomized, Controlled Clinical Trial

(2011) P. Andrew Pearson et al.   OPHTHALMOLOGY

Long-term Benefit of Sustained-Delivery Fluocinolone Acetonide Vitreous Inserts for Diabetic Macular Edema

(2011) Peter A. Campochiaro et al.   OPHTHALMOLOGY

The RESTORE Study

(2011) Paul Mitchell et al.   OPHTHALMOLOGY

Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4

(2010) J. Li et al.   DIABETES

Safety and Efficacy of Ranibizumab in Diabetic Macular Edema (RESOLVE Study): A 12-month, randomized, controlled, double-masked, multicenter phase II study

(2010) P. Massin et al.   DIABETES CARE

Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes

(2010) M. Sasaki et al.   DIABETOLOGIA

Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema

(2010) Michael J. Elman et al.   OPHTHALMOLOGY

Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease

(2009) Giuseppe Paradies et al.   CELL CALCIUM