Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1

Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy

(2019) Hirokazu Muraoka et al.   Cell Reports

Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies

(2019) Annabelle M. Warren et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy

(2019) Tao Wang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Sirtuins as regulators of the cellular stress response and metabolism in marine ectotherms

(2019) M. Christina Vasquez et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

(2019) Pedro Gomes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Update on Diabetic Nephropathy: Core Curriculum 2018

(2018) Kausik Umanath et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Natural products with anti-aging potential: Affected targets and molecular mechanisms

(2018) Cristina-Sorina Cătană et al.   BIOTECHNOLOGY ADVANCES

Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation

(2018) Antoinette Bugyei-Twum et al.   CARDIOVASCULAR RESEARCH

Sirtuins in Renal Health and Disease

(2018) Marina Morigi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

BMP14 induces tenogenic differentiation of bone marrow mesenchymal stem cells in�vitro

(2018) Dan Wang et al.   Experimental and Therapeutic Medicine

Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis

(2018) Qingqing Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-anginal drugs–beliefs and evidence: systematic review covering 50 years of medical treatment

(2018) Roberto Ferrari et al.   EUROPEAN HEART JOURNAL

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy

(2018) Senthilkumar Kalimuthu et al.   Frontiers in Pharmacology

SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress

(2018) Yanrong Zhu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A more tubulocentric view of diabetic kidney disease

(2017) Letizia Zeni et al.   JOURNAL OF NEPHROLOGY

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox Balance

(2016) Kumar Sharma   ANTIOXIDANTS & REDOX SIGNALING

Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

(2016) Lei Zhang et al.   Journal of Translational Medicine

The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling pathway

(2016) Zhenling Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

(2015) Jing Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Store-Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression

(2015) P. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Physiological and pathophysiological roles of NAMPT and NAD metabolism

(2015) Antje Garten et al.   Nature Reviews Endocrinology

Diabetic Kidney Disease: A Report From an ADA Consensus Conference

(2014) Katherine R. Tuttle et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Defining the Role of Trimetazidine in the Treatment of Cardiovascular Disorders: Some Insights on Its Role in Heart Failure and Peripheral Artery Disease

(2014) Piotr Chrusciel et al.   DRUGS

Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis

(2014) I-Chieh Chen et al.   Molecular Cancer

Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy

(2014) Tugba Karadeniz et al.   RENAL FAILURE

Renal Protective Effect of Sirtuin 1

(2014) Yi-jun Dong et al.   Journal of Diabetes Research

Overview of the cellular and molecular basis of kidney fibrosis

(2014) Allison A. Eddy   Kidney International Supplements

Endogenous NAMPT dampens chemokine expression and apoptotic responses in stressed tubular cells

(2013) Alberto Benito-Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

(2013) Kazuhiro Hasegawa et al.   NATURE MEDICINE

The ways and means that fine tune Sirt1 activity

(2013) Javier R. Revollo et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

(2012) Naoki Oshimori et al.   Cell Stem Cell

Additional Use of Trimetazidine in Patients With Chronic Heart Failure

(2012) Lei Zhang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats

(2012) Lina Wu et al.   MOLECULAR BIOLOGY REPORTS

Mammalian Sirt1: insights on its biological functions

(2011) Shahedur Rahman et al.   Cell Communication and Signaling

The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy

(2011) Claire E. Hills et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

(2011) Lilia G Noriega et al.   EMBO REPORTS

Histological predictors for renal prognosis in diabetic nephropathy in diabetes mellitus type 2 patients with overt proteinuria

(2011) TOMONARI OKADA et al.   NEPHROLOGY

Trimetazidine inhibits pressure overload-induced cardiac fibrosis through NADPH oxidase–ROS–CTGF pathway

(2010) Xuehui Liu et al.   CARDIOVASCULAR RESEARCH

Altered renal proximal tubular endocytosis and histology in mice lacking myosin-VI

(2010) Nanami Gotoh et al.   Cytoskeleton

Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase

(2010) Vishal S. Vaidya et al.   KIDNEY INTERNATIONAL

Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice

(2010) Satoru Hayashida et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Trimetazidine Revisited: A Comprehensive Review of the Pharmacological Effects and Analytical Techniques for the Determination of Trimetazidine

(2008) A. Onay-Besikci et al.   Cardiovascular Therapeutics

Endothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin

(2008) M. I. Yilmaz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS