Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling

PROTAC targeted protein degraders: the past is prologue

(2022) Miklós Békés et al.   NATURE REVIEWS DRUG DISCOVERY

Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale

(2022) Michael A. McCoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct targeting of β ‐catenin in the Wnt signaling pathway: Current progress and perspectives

(2021) Zhen Wang et al.   MEDICINAL RESEARCH REVIEWS

Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

(2021) Mathias Wendt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction

(2021) Joo-Leng Low et al.   iScience

Covalent and Noncovalent Targeting of the Tcf4/β-Catenin Strand Interface with β-Hairpin Mimics

(2021) Sarah L. Blosser et al.   ACS Chemical Biology

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns

(2020) W. Seth Horne et al.   Nature Chemistry

Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer

(2020) Anton Cheltsov et al.   Scientific Reports

Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells

(2020) Daniel Y. Yoo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer

(2020) Hongwei Liao et al.   Cell Discovery

Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods

(2020) Dirk Kessler et al.   ChemMedChem

Targeting the Wnt/β-catenin signaling pathway in cancer

(2020) Ya Zhang et al.   Journal of Hematology & Oncology

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction

(2019) Zhen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors

(2019) Peng Sang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

(2019) Philipp M. Cromm et al.   CHEMBIOCHEM

Getting in: emerging methods and design principles for cell-penetrant peptides

(2018) Leila Peraro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage

(2018) A. Held et al.   OSTEOARTHRITIS AND CARTILAGE

Is β-Catenin a Druggable Target for Cancer Therapy?

(2018) Can Cui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

(2018) Jeffrey A. Schneider et al.   Nature Communications

How Big Is Too Big for Cell Permeability?

(2017) Pär Matsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo

(2017) Seung Ho Shin et al.   EBioMedicine

Phage Selection of Chemically Stabilized α-Helical Peptide Ligands

(2016) Philippe Diderich et al.   ACS Chemical Biology

Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling

(2016) Davide Bertoldo et al.   ChemMedChem

CWP232228 targets liver cancer stem cells through Wnt/β‑catenin signaling: a novel therapeutic approach for liver cancer treatment

(2016) Ji‑Young Kim et al.   Oncotarget

Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling

(2016) So-Young Hwang et al.   Cell Reports

Hydrocarbon Stapled Peptides as Modulators of Biological Function

(2015) Philipp M. Cromm et al.   ACS Chemical Biology

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Wnt/ -Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells

(2015) G.-B. Jang et al.   CANCER RESEARCH

A Small-Molecule Antagonist of the  -Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis

(2015) L. Fang et al.   CANCER RESEARCH

Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction through the Optimization of the Acyl Hydrazone Moiety

(2015) J. Leon Catrow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Applications of Protein Epitope Mimetics

(2014) John A. Robinson   CHIMIA

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Targeting the Tcf4 G13ANDE17 Binding Site To Selectively Disrupt β-Catenin/T-Cell Factor Protein–Protein Interactions

(2013) Zheng Huang et al.   ACS Chemical Biology

Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling

(2013) Gernot Hahne et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling

(2013) Hong-Kui Cui et al.   CELL RESEARCH

Rational Design of Small-Molecule Inhibitors for β-Catenin/T-Cell Factor Protein–Protein Interactions by Bioisostere Replacement

(2012) Binxun Yu et al.   ACS Chemical Biology

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Inhibition of oncogenic Wnt signaling through direct targeting of  -catenin

(2012) T. N. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction

(2011) Wang Tian et al.   BIOCHEMISTRY

A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis

(2011) Wei Wang et al.   CELL RESEARCH

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

(2011) Young-Woo Kim et al.   Nature Protocols

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

Structural basis of coactivation of liver receptor homolog-1 by  -catenin

(2011) F. Yumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

(2011) F. C. Gonsalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and Structural Characterization of β-Catenin Interactions with Nonphosphorylated and CK2-Phosphorylated Lef-1

(2010) Jinglucy Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells

(2009) Pay-Chin Leow et al.   INVESTIGATIONAL NEW DRUGS

Design and Synthesis of Novel Diaminoquinazolines within VivoEfficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition

(2009) Christoph M. Dehnhardt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

(2008) A Jeanes et al.   ONCOGENE

Crystal Structure of a Full-Length β-Catenin

(2008) Yi Xing et al.   STRUCTURE