Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns

Design and Structure Determination of a Composite Zinc Finger Containing a Nonpeptide Foldamer Helical Domain

(2019) Caterina Maria Lombardo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploring the Functional Consequences of Protein Backbone Alteration in Ubiquitin through Native Chemical Ligation

(2019) Halina M. Werner et al.   CHEMBIOCHEM

The de novo design of α-helical peptides for supramolecular self-assembly

(2019) Joseph L Beesley et al.   CURRENT OPINION IN BIOTECHNOLOGY

Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer’s Disease and Other Amyloid Diseases

(2018) Adam G. Kreutzer et al.   ACCOUNTS OF CHEMICAL RESEARCH

Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration

(2018) Kelly L. George et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

(2018) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineered Metalloenzymes with Non-Canonical Coordination Environments

(2018) Takahiro Hayashi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

(2018) Naomi Robertson et al.   MOLECULES

Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection

(2018) Carolin Mueller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein

(2018) Chino C. Cabalteja et al.   CHEMBIOCHEM

Synthetic Control of Tertiary Helical Structures in Short Peptides

(2018) Michael G. Wuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel protein science enabled by total chemical synthesis

(2018) Stephen B. H. Kent   PROTEIN SCIENCE

Backbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation

(2017) Karunakar Kar et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Recognition within the Cavity of a Foldamer Helix Bundle: Encapsulation of Primary Alcohols in Aqueous Conditions

(2017) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Helical Oligourea Foldamers as Powerful Hydrogen Bonding Catalysts for Enantioselective C–C Bond-Forming Reactions

(2017) Diane Bécart et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterogeneous-Backbone Foldamer Mimics of Zinc Finger Tertiary Structure

(2017) Kelly L. George et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controlling Dipole Orientation through Curvature: Aromatic Foldamer Bent β-Sheets and Helix–Sheet–Helix Architectures

(2017) Arthur Lamouroux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding and reprogramming the genetic code

(2017) Jason W. Chin   NATURE

Designing cooperatively folded abiotic uni- and multimolecular helix bundles

(2017) Soumen De et al.   Nature Chemistry

Enzyme stabilization via computationally guided protein stapling

(2017) Eric J. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures

(2017) Bobo Dang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coiled Coils – A Model System for the 21st Century

(2017) Andrei N. Lupas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Design of an enantioselective artificial metallo-hydratase enzyme containing an unnatural metal-binding amino acid

(2017) Ivana Drienovská et al.   Chemical Science

A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix

(2016) Yana K. Rennie et al.   ACS Chemical Biology

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

(2016) George M. Burslem et al.   CHEMICAL COMMUNICATIONS

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase

(2016) Richard Obexer et al.   Nature Chemistry

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

A perfluoroaromatic abiotic analog of H2 relaxin enabled by rapid flow-based peptide synthesis

(2016) Tessa Lühmann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic

(2016) Chenguang Lou et al.   Nature Communications

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

(2016) Chao Wang et al.   Scientific Reports

Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

(2015) Hans Renata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Encoded libraries of chemically modified peptides

(2015) Christian Heinis et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics

(2015) Michael G. Wuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation

(2015) Gavin W. Collie et al.   Nature Chemistry

Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose

(2015) Nagula Chandramouli et al.   Nature Chemistry

Site-selective protein-modification chemistry for basic biology and drug development

(2015) Nikolaus Krall et al.   Nature Chemistry

Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold

(2015) James W. Checco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids

(2015) Ivana Drienovská et al.   Chemical Science

Building Proficient Enzymes with Foldamer Prostheses

(2014) Clemens Mayer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intramolecular Thioether Crosslinking of Therapeutic Proteins to Increase Proteolytic Stability

(2014) Joel Lindgren et al.   CHEMBIOCHEM

Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle

(2014) Jonathan P. Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and High-Resolution Structure of a β3-Peptide Bundle Catalyst

(2014) Pam S. P. Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

X-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ17–36

(2014) Ryan K. Spencer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein disulfide engineering

(2013) Alan A. Dombkowski et al.   FEBS LETTERS

β-Hairpin-Mediated Nucleation of Polyglutamine Amyloid Formation

(2013) Karunakar Kar et al.   JOURNAL OF MOLECULAR BIOLOGY

Foldameric α/β-Peptide Analogs of the β-Sheet-Forming Antiangiogenic Anginex: Structure and Bioactivity

(2013) Zsófia Hegedüs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein-like Tertiary Folding Behavior from Heterogeneous Backbones

(2013) Zachary E. Reinert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Extending Foldamer Design beyond α-Helix Mimicry: α/β-Peptide Inhibitors of Vascular Endothelial Growth Factor Signaling

(2012) Holly S. Haase et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

(2012) Pin-Nan Cheng et al.   Nature Chemistry

Protein Side-Chain Translocation MutagenesisviaIncorporation of Peptoid Residues

(2011) Byoung-Chul Lee et al.   ACS Chemical Biology

Synthetic foldamers

(2011) Gilles Guichard et al.   CHEMICAL COMMUNICATIONS

Synthesis and chemoselective intramolecular crosslinking of a HER2-binding affibody

(2009) Torun Ekblad et al.   BIOPOLYMERS

β-Hairpin Peptidomimetics: Design, Structures and Biological Activities

(2008) John A. Robinson   ACCOUNTS OF CHEMICAL RESEARCH

Artificial Chemokines: Combining Chemistry and Molecular Biology for the Elucidation of Interleukin-8 Functionality

(2008) Ralf David et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of a Site-Specific DNA Cleaving Protein

(2008) Hyun Soo Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY