Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines

(2019) Emily Linnane et al.   NUCLEIC ACIDS RESEARCH

UNC119A Decreases the Membrane Binding of Myristoylated c-Src

(2018) Nelli Erwin et al.   CHEMBIOCHEM

Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

(2018) Hong Jiang et al.   CHEMICAL REVIEWS

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions

(2018) Nadine Kaiser et al.   CHEMBIOCHEM

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

(2018) William McCoull et al.   ACS Chemical Biology

Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein–Protein Interactions

(2017) Dennis M. Krüger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

(2017) André Mateus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3

(2016) Mamta Jaiswal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein lipid modifications-More than just a greasy ballast

(2016) Andreas Hentschel et al.   PROTEOMICS

Identification of pyrazolopyridazinones as PDEδ inhibitors

(2016) Björn Papke et al.   Nature Communications

Hydrocarbon Stapled Peptides as Modulators of Biological Function

(2015) Philipp M. Cromm et al.   ACS Chemical Biology

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Specificity of Lipoprotein Chaperones for the Characteristic Lipidated Structural Motifs of their Cognate Lipoproteins

(2015) Tom Mejuch et al.   CHEMBIOCHEM

Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction

(2014) Christopher H. Douse et al.   ACS Chemical Biology

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis

(2013) YuKyung Lee et al.   CELL CYCLE

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119

(2012) Shehab A Ismail et al.   EMBO JOURNAL

Targeting protein lipidation in disease

(2012) Marilyn D. Resh   TRENDS IN MOLECULAR MEDICINE

Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteins

(2012) Ryan Constantine et al.   VISION RESEARCH

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

(2011) K. J. Wright et al.   GENES & DEVELOPMENT

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

UNC119 is required for G protein trafficking in sensory neurons

(2011) Houbin Zhang et al.   NATURE NEUROSCIENCE

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

(2011) Young-Woo Kim et al.   Nature Protocols

Post-translational myristoylation: Fat matters in cellular life and death

(2010) Dale D.O. Martin et al.   BIOCHIMIE