Small-Molecule Inhibitors Targeting FEN1 for Cancer Therapy

Flap endonuclease 1 Facilitated Hepatocellular Carcinoma Progression by Enhancing USP7/MDM2-mediated P53 Inactivation

(2022) Saiyan Bian et al.   International Journal of Biological Sciences

DNA repair defects in cancer and therapeutic opportunities

(2022) Jessica L. Hopkins et al.   GENES & DEVELOPMENT

Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells

(2022) Jing Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

FEN1 inhibitor synergizes with low-dose camptothecin to induce increased cell killing via the mitochondria mediated apoptotic pathway

(2021) Ting Wu et al.   GENE THERAPY

PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway

(2021) Michelle Shen et al.   DNA REPAIR

Fragment-based drug design facilitates selective kinase inhibitor discovery

(2021) Zhi-Zheng Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers

(2021) Katia A. Mesquita et al.   Cancers

The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ

(2021) Abdulbaqi Al-Kawaz et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting FEN1 Suppresses the Proliferation of Chronic Myeloid Leukemia Cells Through Regulating Alternative End-Joining Pathways

(2021) Yalin Zhu et al.   DNA AND CELL BIOLOGY

Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway

(2021) Feng Ji et al.   Journal of Hematology & Oncology

Identification of Flap Endonuclease 1 With Diagnostic and Prognostic Value in Breast Cancer

(2021) Min Wu et al.   Frontiers in Oncology

Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update

(2021) Robert Roskoski Jr.   PHARMACOLOGICAL RESEARCH

Error-prone, stress-induced 3′ flap–based Okazaki fragment maturation supports cell survival

(2021) Haitao Sun et al.   SCIENCE

The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma

(2021) Guangxian Zhong et al.   International Journal of General Medicine

Small Molecule Inhibitors Targeting the Key Proteins in DNA Damage Response for Cancer Therapy

(2020) Lulu Li et al.   CURRENT MEDICINAL CHEMISTRY

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

(2020) Koen D. Flach et al.   CANCER RESEARCH

Small molecules, big impact: 20 years of targeted therapy in oncology

(2020) Philippe L Bedard et al.   LANCET

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

(2020) Elaine Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs

(2020) Jing Zhang et al.   Cell Death & Disease

Flap endonuclease 1 (FEN1) as a novel diagnostic and prognostic biomarker for gastric cancer

(2020) Enfa Zhao et al.   Clinics and Research in Hepatology and Gastroenterology

miR‑140‑5p inhibits cervical cancer cell phenotypes via downregulating FEN1 to halt the cell cycle

(2020) Yanrong Guo et al.   Molecular Medicine Reports

Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis

(2020) Lu Xu et al.   ONCOLOGY REPORTS

Draining the FEN1s for cancer therapy

(2020) Giacomo G. Rossetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

(2020) Longxing Cao et al.   SCIENCE

Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells

(2019) Long Ma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

TGFβ1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

(2019) Chuanfei Li et al.   Aging-US

Molecular Docking: Shifting Paradigms in Drug Discovery

(2019) Luca Pinzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer

(2019) Xiao Lu et al.   ONCOGENE

FEN1 inhibitor increases sensitivity of radiotherapy in cervical cancer cells

(2019) Jin‐Li Li et al.   Cancer Medicine

Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non–Small-Cell Lung Cancer

(2018) Keqiang Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells

(2018) Lingfeng He et al.   DNA REPAIR

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems

(2018) Hao Zhang et al.   NANO LETTERS

Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1

(2018) Hong Xu et al.   NUCLEIC ACIDS RESEARCH

Regulation of adrenal and ovarian steroidogenesis by miR-132

(2017) Zhigang Hu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

(2017) Lingfeng He et al.   Molecular Oncology

Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

(2017) Susan E. Tsutakawa et al.   Nature Communications

Investigation of human flap structure-specific endonuclease 1 (FEN1) activity on primer-template models and exploration of a substrate-based FEN1 inhibitor

(2016) Sai Ba et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation

(2016) H Sun et al.   ONCOGENE

Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1

(2016) I-Cheng Cheng et al.   PLOS BIOLOGY

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

TheSaccharomyces cerevisiaeDna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication

(2015) Maryna Levikova et al.   NUCLEIC ACIDS RESEARCH

A physiological significance of the functional interaction between Mus81 and Rad27 in homologous recombination repair

(2015) Huong Phung Thi Thu et al.   NUCLEIC ACIDS RESEARCH

Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China

(2015) Xingyuan Jiao et al.   Scientific Reports

Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis

(2014) KEJIA WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression

(2012) Zhigang Guo et al.   MOLECULAR CELL

Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1

(2012) Meng Xu et al.   NUCLEIC ACIDS RESEARCH

Kinetics of endogenous mouse FEN1 in base excision repair

(2012) Liv Kleppa et al.   NUCLEIC ACIDS RESEARCH

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

(2011) Li Zheng et al.   CELL RESEARCH

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

(2010) Zhigang Guo et al.   Nature Chemical Biology

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

DNA Repair in Mammalian Cells

(2009) A. B. Robertson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Acetylation of Dna2 Endonuclease/Helicase and Flap Endonuclease 1 by p300 Promotes DNA Stability by Creating Long Flap Intermediates

(2009) Lata Balakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion

(2009) Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing

(2009) K. J. McManus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flap Endonuclease 1 Contributes to Telomere Stability

(2008) Abhishek Saharia et al.   CURRENT BIOLOGY

Human Flap Endonuclease I Is in Complex with Telomerase and Is Required for Telomerase-mediated Telomere Maintenance

(2008) Shilpa Sampathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-strand break repair and genetic disease

(2008) Keith W. Caldecott   NATURE REVIEWS GENETICS