Draining the FEN1s for cancer therapy

Ctf18-RFC and DNA Pol ϵ form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication

(2020) Katy Stokes et al.   NUCLEIC ACIDS RESEARCH

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

(2020) Elaine Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

(2019) Kristen E. Mengwasser et al.   MOLECULAR CELL

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification

(2018) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

(2017) Thomas A. Ward et al.   PLoS One

Visualization of recombination-mediated damage bypass by template switching

(2014) Michele Giannattasio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination

(2012) B H Lok et al.   ONCOGENE

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

(2010) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA