Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells

Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice

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Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs

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Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

(2020) Matteo Berti et al.   Nature Communications

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

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Repeat expansions confer WRN dependence in microsatellite-unstable cancers

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CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs

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(2019) Alexandra M. Miller et al.   NATURE

Activation of the unfolded protein response via inhibition of protein disulfide isomerase decreases the capacity for DNA repair to sensitize glioblastoma to radiotherapy

(2019) Yajing Liu et al.   CANCER RESEARCH

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

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TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss

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Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

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Maftools: efficient and comprehensive analysis of somatic variants in cancer

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STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

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Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

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The essential kinase ATR: ensuring faithful duplication of a challenging genome

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PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

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Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

EXD2 promotes homologous recombination by facilitating DNA end resection

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(2016) Jiguang Wang et al.   NATURE GENETICS

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

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DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair

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Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

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HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal

(2015) Andrew C. Kile et al.   MOLECULAR CELL

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SMARCAL1 maintains telomere integrity during DNA replication

(2015) Lisa A. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Applying Synthetic Lethality for the Selective Targeting of Cancer

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The FEN1 E359K germline mutation disrupts the FEN1–WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers

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The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

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The DNA damage checkpoint response to replication stress: A Game of Forks

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Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

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A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy

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Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE