FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

Upregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma

(2016) Zihao Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma

(2016) Bingyan Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

(2016) Jack C Exell et al.   Nature Chemical Biology

The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation

(2016) H Sun et al.   ONCOGENE

Upregulation of long noncoding RNA SPRY4-IT1 correlates with tumor progression and poor prognosis in cervical cancer

(2016) Yang Cao et al.   FEBS Open Bio

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

(2015) Jianwei Wang et al.   BMC CANCER

Okazaki fragment maturation involves  -segment error editing by the mammalian FEN1/MutS  functional complex

(2015) S. Liu et al.   EMBO JOURNAL

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

Association of functional FEN1 genetic variants and haplotypes and breast cancer risk

(2014) Zheng Lv et al.   GENE

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression

(2012) Zhigang Guo et al.   MOLECULAR CELL

Two Novel Determinants of Etoposide Resistance in Small Cell Lung Cancer

(2011) M. H. Lawson et al.   CANCER RESEARCH

How do real tumors become resistant to cisplatin?

(2011) Piet Borst et al.   CELL CYCLE

High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance

(2010) N. E. Simpson et al.   CANCER RESEARCH

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

(2010) Zhigang Guo et al.   Nature Chemical Biology

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

DNA Ligase I Deficiency Leads to Replication-Dependent DNA Damage and Impacts Cell Morphology without Blocking Cell Cycle Progression

(2009) S. Soza et al.   MOLECULAR AND CELLULAR BIOLOGY

Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways

(2009) X. Liu et al.   MOLECULAR CANCER RESEARCH

Mechanisms of Chemotherapeutic Drug Resistance in Cancer Therapy—A Quick Review

(2009) Fu-Shing Liu   Taiwanese Journal of Obstetrics & Gynecology

FYNis overexpressed in human prostate cancer

(2008) Edwin M. Posadas et al.   BJU INTERNATIONAL

Efficacy and side effects of cisplatin- and carboplatin-based doublet chemotherapeutic regimens versus non-platinum-based doublet chemotherapeutic regimens as first line treatment of metastatic non-small cell lung carcinoma: A systematic review of randomized controlled trials

(2007) Anand Rajeswaran et al.   LUNG CANCER