FEN1 inhibitor synergizes with low-dose camptothecin to induce increased cell killing via the mitochondria mediated apoptotic pathway

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

(2020) Elaine Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

(2019) Kristen E. Mengwasser et al.   MOLECULAR CELL

FEN1 inhibitor increases sensitivity of radiotherapy in cervical cancer cells

(2019) Jin‐Li Li et al.   Cancer Medicine

Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells

(2018) Lingfeng He et al.   DNA REPAIR

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

(2017) Lingfeng He et al.   Molecular Oncology

Strategies Targeting DNA Topoisomerase I in Cancer Chemotherapy: Camptothecins, Nanocarriers for Camptothecins, Organic Non-Camptothecin Compounds and Metal Complexes

(2016) Kurtulus Gokduman   CURRENT DRUG TARGETS

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

(2016) Jack C Exell et al.   Nature Chemical Biology

The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation

(2016) H Sun et al.   ONCOGENE

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

Okazaki fragment maturation involves  -segment error editing by the mammalian FEN1/MutS  functional complex

(2015) S. Liu et al.   EMBO JOURNAL

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

(2015) Marianne S. Poruchynsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting DNA damage response in cancer therapy

(2014) Noriko Hosoya et al.   CANCER SCIENCE

The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once

(2014) Susan E. Tsutakawa et al.   DNA REPAIR

Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis

(2014) KEJIA WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features

(2013) Rania Elakoum et al.   BIOCHIMIE

An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

(2013) Derek M. van Pel et al.   PLoS Genetics

Including Total EGFR Staining in Scoring Improves EGFR Mutations Detection by Mutation-Specific Antibodies and EGFR TKIs Response Prediction

(2011) Shang-Gin Wu et al.   PLoS One

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing

(2009) K. J. McManus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA