Roles of microglial mitophagy in neurological disorders

Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model

(2022) Jingru Qiu et al.   NEUROPHARMACOLOGY

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline

(2022) Claudia Schwarz et al.   JAMA Network Open

Neuronal Mitophagy: Friend or Foe?

(2021) Christina Doxaki et al.   Frontiers in Cell and Developmental Biology

Microglial MT1 activation inhibits LPS‐induced neuroinflammation via regulation of metabolic reprogramming

(2021) Chao Gu et al.   AGING CELL

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination

(2021) Yumiko Oshima et al.   JOURNAL OF CELL BIOLOGY

Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation

(2021) Bin Han et al.   Genome Medicine

NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

(2021) Yao Zhao et al.   Journal of Neuroinflammation

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

(2021) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

(2021) Joshua C. Drake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

(2021) Xiaojuan Han et al.   Redox Biology

Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease

(2021) Chongyang Chen et al.   JOURNAL OF PINEAL RESEARCH

Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease

(2020) Sandra Franco-Iborra et al.   Autophagy

Curcumin attenuates cerebral ischemia-reperfusion injury through regulating mitophagy and preserving mitochondrial function

(2020) Weiwei Wang et al.   CURRENT NEUROVASCULAR RESEARCH

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

(2020) Ting-Ting Xu et al.   Aging-US

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

(2020) Xiaoli Wu et al.   Autophagy

Sustained mitochondrial biogenesis is essential to maintain caloric restriction-induced beige adipocytes

(2020) Raja Gopal Reddy Mooli et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Resveratrol Improves Bnip3-Related Mitophagy and Attenuates High-Fat-Induced Endothelial Dysfunction

(2020) Chen Li et al.   Frontiers in Cell and Developmental Biology

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans

(2020) Xin Yang et al.   Aging-US

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

(2020) Sahabuddin Ahmed et al.   BRAIN BEHAVIOR AND IMMUNITY

Iron loss triggers mitophagy through induction of mitochondrial ferritin

(2020) Yuichi Hara et al.   EMBO REPORTS

Cardiolipin-dependent mitophagy guides outcome after traumatic brain injury

(2019) Honglu Chao et al.   JOURNAL OF NEUROSCIENCE

Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy

(2019) Sijie Tan et al.   Scientific Reports

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Induction of Autophagy and Activation of SIRT-1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and Differentiated 3D Human Neural Progenitor Cells

(2019) Ravikanth Velagapudi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

(2019) Nicola Vannini et al.   Cell Stem Cell

Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics

(2019) Annadurai Thangaraj et al.   Autophagy

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

(2019) Xiang He et al.   EMBO JOURNAL

Atractylenolide III ameliorates cerebral ischemic injury and neuroinflammation associated with inhibiting JAK2/STAT3/Drp1-dependent mitochondrial fission in microglia

(2019) Kecheng Zhou et al.   PHYTOMEDICINE

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

(2019) Evandro F. Fang et al.   Nature Communications

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

(2019) Anushka Chakravorty et al.   Frontiers in Aging Neuroscience

The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

(2019) Yahyah Aman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Emerging concepts of mitochondrial dysfunction in Parkinson’s disease progression: Pathogenic and therapeutic implications

(2019) Linchi Rani et al.   MITOCHONDRION

NAD metabolism: Implications in aging and longevity

(2018) Keisuke Yaku et al.   AGEING RESEARCH REVIEWS

HIV-1 TAT-mediated microglial activation: Role of mitochondrial dysfunction and defective mitophagy

(2018) Annadurai Thangaraj et al.   Autophagy

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages

(2018) Yaw Duah Boakye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro

(2018) Yu-Hong Jing et al.   EXPERIMENTAL GERONTOLOGY

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics

(2018) Stephani A. Davis et al.   NEUROSCIENCE LETTERS

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway

(2018) Yun Zhou et al.   Cancer Medicine

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

(2018) Jun Ren et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes

(2018) Chenzhong Wang et al.   BioScience Trends

New methods for monitoring mitochondrial biogenesis and mitophagy in vitro and in vivo

(2017) Jessica A Williams et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Bioenergetic regulation of microglia

(2017) Soumitra Ghosh et al.   GLIA

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

(2017) Elizabeth S. Childress et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro

(2017) Junli Ye et al.   JOURNAL OF NEUROCHEMISTRY

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

The pharmacological regulation of cellular mitophagy

(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

(2017) Petra Füger et al.   NATURE NEUROSCIENCE

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation

(2017) Mitsuhiko Katoh et al.   Scientific Reports

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

(2017) Elodie Villa et al.   Cell Reports

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

The Mitochondrial Basis of Aging and Age-Related Disorders

(2017) Sarika Srivastava   Genes

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

(2016) Yao Kuang et al.   Autophagy

Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs

(2016) Marcos Roberto de Oliveira et al.   BIOTECHNOLOGY ADVANCES

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

(2016) V E Kagan et al.   CELL DEATH AND DIFFERENTIATION

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Peroxiredoxin 5 (Prx5) decreases LPS-induced microglial activation through regulation of Ca 2+ /calcineurin-Drp1-dependent mitochondrial fission

(2016) Junghyung Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway

(2016) Raymonde Szargel et al.   HUMAN MOLECULAR GENETICS

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

(2016) Benjamin Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

(2016) Andrew S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy

(2015) Cathrin Meissner et al.   Autophagy

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease

(2015) B Khalil et al.   Cell Death & Disease

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2014) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast

(2013) Kyung-Mi Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes

(2013) Jing Xiong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy

(2012) Noriko Kondo-Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

(2011) Z. Zheng et al.   DIABETES

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of Serine 114 on Atg32 mediates mitophagy

(2011) Yoshimasa Aoki et al.   MOLECULAR BIOLOGY OF THE CELL

Cellular regulators of protein kinase CK2

(2010) Mathias Montenarh   CELL AND TISSUE RESEARCH

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling

(2009) D. Sha et al.   HUMAN MOLECULAR GENETICS

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA