Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model

Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities

(2021) Jannik Prasuhn et al.   Frontiers in Cell and Developmental Biology

Role of mitophagy in mitochondrial quality control: Mechanisms and potential implications for neurodegenerative diseases

(2021) Xiao-Le Wang et al.   PHARMACOLOGICAL RESEARCH

Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor

(2021) Pei-Xin Shen et al.   EBioMedicine

Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics

(2021) Soumya R. Mishra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease

(2021) Katja Badanjak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

(2021) Peiling Luan et al.   Science Translational Medicine

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

(2021) Xiaojuan Han et al.   Redox Biology

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

(2020) Insup Choi et al.   Nature Communications

Microglia: Agents of the CNS Pro-Inflammatory Response

(2020) José A. Rodríguez-Gómez et al.   Cells

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

(2020) Sahabuddin Ahmed et al.   BRAIN BEHAVIOR AND IMMUNITY

Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease

(2020) Yue Qin et al.   BRAIN BEHAVIOR AND IMMUNITY

Interplay Between NLRP3 Inflammasome and Autophagy

(2020) Monika Biasizzo et al.   Frontiers in Immunology

Targeting mitophagy in Parkinson's disease

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Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

(2020) Ana Belen Malpartida et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

(2019) Zhuo Gong et al.   Journal of Neuroinflammation

Significant roles of neuroinflammation in Parkinson’s disease: therapeutic targets for PD prevention

(2019) Yujeong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo

(2019) Anil Ahsan et al.   CNS Neuroscience & Therapeutics

Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson’s disease via promoting mitophagy

(2019) Zhao-Li Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

(2019) Sofie Lautrup et al.   NEUROCHEMISTRY INTERNATIONAL

mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP

(2019) Yaling Hu et al.   GLIA

Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

(2019) Małgorzata Kujawska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIV-1 TAT-mediated microglial activation: Role of mitochondrial dysfunction and defective mitophagy

(2018) Annadurai Thangaraj et al.   Autophagy

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

(2018) Eunju Lee et al.   CELL DEATH AND DIFFERENTIATION

TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease

(2018) Manru Ren et al.   EXPERIMENTAL NEUROLOGY

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Parkinson disease

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Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

(2016) Francisco A. Tomás-Barberán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

(2011) Hidekazu Ishimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism☆

(2009) Mar Larrosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY