Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

(2020) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Long-term oral melatonin alleviates memory deficits, reduces amyloid-β deposition associated with downregulation of BACE1 and mitophagy in APP/PS1 transgenic mice

(2020) Cuimei Sun et al.   NEUROSCIENCE LETTERS

Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis

(2020) Tongyu Rui et al.   JOURNAL OF PINEAL RESEARCH

Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease

(2019) Chongyang Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacological doses of melatonin impede cognitive decline in tau‐related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux

(2019) Enrique Luengo et al.   JOURNAL OF PINEAL RESEARCH

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

(2019) Qiong Feng et al.   Autophagy

Effects of the drug combination memantine and melatonin on impaired memory and brain neuronal deficits in an amyloid‐predominant mouse model of Alzheimer's disease

(2019) Monika Jürgenson et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Melatonin does not produce sedation in rats: A chronobiological study

(2019) Susana Barbosa-Méndez et al.   CHRONOBIOLOGY INTERNATIONAL

Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice

(2018) Kirsty Foote et al.   AGING CELL

Melatonin induces mechanisms of brain resilience against neurodegeneration

(2018) Rubén Corpas et al.   JOURNAL OF PINEAL RESEARCH

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

Proteomic Profiling of Brain and Testis Reveals the Diverse Changes in Ribosomal Proteins in fmr1 Knockout Mice

(2018) Benhong Xu et al.   NEUROSCIENCE

Protective roles of melatonin against the amyloid-dependent development of Alzheimer’s disease: A critical review

(2018) Bruno Vincent   PHARMACOLOGICAL RESEARCH

Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome

(2018) Christopher M. Depner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin attenuates myocardial ischemia reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways

(2018) Ying Zhang et al.   JOURNAL OF PINEAL RESEARCH

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation

(2017) Patricia Martín-Maestro et al.   Frontiers in Molecular Neuroscience

Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

(2017) Mark A. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders

(2016) Showkat Ahmad Ganie et al.   REJUVENATION RESEARCH

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

(2016) Yu Hu et al.   Oncotarget

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

(2015) G. O’Neal-Moffitt et al.   Molecular Neurodegeneration

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

(2015) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory

(2015) Oliver Stiedl et al.   Frontiers in Pharmacology

Melatonin synergizes with citalopram to induce antidepressant-like behavior and to promote hippocampal neurogenesis in adult mice

(2014) Gerardo Ramírez-Rodríguez et al.   JOURNAL OF PINEAL RESEARCH

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

JNK regulates the photic response of the mammalian circadian clock

(2012) Hikari Yoshitane et al.   EMBO REPORTS

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome

(2012) Andrea Corrales et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

(2012) Seithikurippu R. Pandi-Perumal et al.   NEUROTOXICITY RESEARCH

Activity of all JNK isoforms contributes to neurite growth in spiral ganglion neurons

(2011) Patrick J. Atkinson et al.   HEARING RESEARCH

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Increasing proteome coverage with offline RP HPLC coupled to online RP nanoLC–MS

(2011) Emine Gokce et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson’s disease phenotype in the mouse

(2010) Naveen Kumar Singhal et al.   JOURNAL OF PINEAL RESEARCH

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

Long-term melatonin administration protects brain mitochondria from aging

(2009) Miguel Carretero et al.   JOURNAL OF PINEAL RESEARCH

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease

(2009) James M. Olcese et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE