Macrophage diversity in cancer revisited in the era of single-cell omics

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

(2022) Martin Guilliams et al.   CELL

Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level

(2022) Yanxiang Deng et al.   SCIENCE

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

(2022) Ao Chen et al.   CELL

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

(2022) Rosa Barreira da Silva et al.   NATURE IMMUNOLOGY

Monocyte Regulation in Homeostasis and Malignancy

(2021) Amy Robinson et al.   TRENDS IN IMMUNOLOGY

Insights Gained from Single-Cell Analysis of Immune Cells in the Tumor Microenvironment

(2021) Xianwen Ren et al.   Annual Review of Immunology

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

(2021) Sijin Cheng et al.   CELL

Origins, Biology, and Diseases of Tissue Macrophages

(2021) Nehemiah Cox et al.   Annual Review of Immunology

Redefining macrophage and neutrophil biology in the metastatic cascade

(2021) Esra Güç et al.   IMMUNITY

Heme catabolism by tumor-associated macrophages controls metastasis formation

(2021) Francesca Maria Consonni et al.   NATURE IMMUNOLOGY

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

(2021) Ana Rita Pombo Antunes et al.   NATURE NEUROSCIENCE

Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages

(2021) Samantha B Kemp et al.   Life Science Alliance

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

(2021) Toshiro Hara et al.   CANCER CELL

Spatially organized multicellular immune hubs in human colorectal cancer

(2021) Karin Pelka et al.   CELL

Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

(2021) Kevin Mulder et al.   IMMUNITY

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

(2021) María Casanova-Acebes et al.   NATURE

Exploring tissue architecture using spatial transcriptomics

(2021) Anjali Rao et al.   NATURE

A single-cell and spatially resolved atlas of human breast cancers

(2021) Sunny Z. Wu et al.   NATURE GENETICS

Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy

(2021) Yu-Chen Wang et al.   Nature Communications

Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level

(2021) Yingcheng Wu et al.   Cancer Discovery

A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

(2021) Li-Heng Che et al.   Cell Discovery

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

(2021) Youmna Kfoury et al.   CANCER CELL

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

(2021) Srivatsan Raghavan et al.   CELL

Single-cell analysis revealed that IL4I1 promoted ovarian cancer progression

(2021) Hongyu Zhao et al.   Journal of Translational Medicine

Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity

(2021) Giusy Di Conza et al.   NATURE IMMUNOLOGY

Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages

(2021) Qianqian Zhang et al.   Nature Communications

Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

(2021) Mikhail Binnewies et al.   Cell Reports

Macrophages are metabolically heterogeneous within the tumor microenvironment

(2021) Xenia Geeraerts et al.   Cell Reports

Resolving the immune landscape of human prostate at a single-cell level in health and cancer

(2021) Zewen Kelvin Tuong et al.   Cell Reports

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

(2021) Liyang Fei et al.   Frontiers in Immunology

A Dynamic Transcriptome Map of Different Tissue Microenvironment Cells Identified During Gastric Cancer Development Using Single-Cell RNA Sequencing

(2021) Honghao Yin et al.   Frontiers in Immunology

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

Single cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironment

(2020) Anuja Sathe et al.   CLINICAL CANCER RESEARCH

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

(2020) Anthony R. Cillo et al.   IMMUNITY

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

(2020) Helena Aegerter et al.   NATURE IMMUNOLOGY

Macrophage targeting in cancer

(2020) Martha Lopez‐Yrigoyen et al.   Annals of the New York Academy of Sciences

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

(2020) Lei Zhang et al.   CELL

Establishment and Maintenance of the Macrophage Niche

(2020) Martin Guilliams et al.   IMMUNITY

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

(2020) Nayoung Kim et al.   Nature Communications

Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

(2020) Yonatan Katzenelenbogen et al.   CELL

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

(2020) Martina Molgora et al.   CELL

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

(2020) Yu-Pei Chen et al.   CELL RESEARCH

Determinants of Resident Tissue Macrophage Identity and Function

(2020) Camille Blériot et al.   IMMUNITY

Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth

(2020) Ruo-Yu Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

(2020) Ahmed Sadik et al.   CELL

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

(2020) Ankur Sharma et al.   CELL

Metabolic programming of tumor associated macrophages in the context of cancer treatment

(2020) Thomas Crezee et al.   Annals of Translational Medicine

Targeting MARCO and IL-37R on immunosuppressive macrophages in lung cancer blocks regulatory T cells and supports cytotoxic lymphocyte function

(2020) Linnéa La Fleur et al.   CANCER RESEARCH

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

(2020) Yunfan Sun et al.   CELL

High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue

(2020) Yang Liu et al.   CELL

A single cell atlas of the human liver tumor microenvironment

(2020) Hassan Massalha et al.   Molecular Systems Biology

Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

(2020) Silke Eisinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

(2020) Yan Zhou et al.   Nature Communications

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

(2019) Pieter Goossens et al.   Cell Metabolism

The potentials of CCL 2‐ CCR 2 blockers including propagermanium as anticancer agents

(2019) Kanae Yumimoto et al.   CANCER SCIENCE

A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer

(2019) Johanna Wagner et al.   CELL

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric Cancer

(2019) Peng Zhang et al.   Cell Reports

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves

(2019) Julia Kolter et al.   IMMUNITY

Droplet-based combinatorial indexing for massive-scale single-cell chromatin accessibility

(2019) Caleb A. Lareau et al.   NATURE BIOTECHNOLOGY

The Ontogeny of Monocyte Subsets

(2019) Anja A. Wolf et al.   Frontiers in Immunology

The Endless Saga of Monocyte Diversity

(2019) Stefania Canè et al.   Frontiers in Immunology

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

(2018) Amir Giladi et al.   NATURE CELL BIOLOGY

Macrophages: The Road Less Traveled, Changing Anticancer Therapy

(2018) Jennifer L. Guerriero   TRENDS IN MOLECULAR MEDICINE

Diverse Functions of Macrophages in Different Tumor Microenvironments

(2018) Ming Yang et al.   CANCER RESEARCH

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

(2018) Matthew M. Gubin et al.   CELL

Tumour heterogeneity and metastasis at single-cell resolution

(2018) Devon A. Lawson et al.   NATURE CELL BIOLOGY

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

(2017) Alberto Yáñez et al.   IMMUNITY

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

(2016) Anna-Maria Georgoudaki et al.   Cell Reports

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

(2016) Robert L. Bowman et al.   Cell Reports

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

(2015) R. Hughes et al.   CANCER RESEARCH

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

(2015) Johanna A. Knipper et al.   IMMUNITY

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study

(2015) Philippe A Cassier et al.   LANCET ONCOLOGY

Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state

(2015) Assaf Rotem et al.   NATURE BIOTECHNOLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

(2015) William D. Tap et al.   NEW ENGLAND JOURNAL OF MEDICINE

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Activated CD69+ T Cells Foster Immune Privilege by Regulating IDO Expression in Tumor-Associated Macrophages

(2011) Q. Zhao et al.   JOURNAL OF IMMUNOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL