Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

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IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming

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Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

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Glycolytic Activation of Peritumoral Monocytes Fosters Immune Privilege via PFKFB3-PD-L1 axis in Human Hepatocellular Carcinoma

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The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc

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Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

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A cellular census of human lungs identifies novel cell states in health and in asthma

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EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

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Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

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The interplay between critical transcription factors and microRNAs in the control of normal and malignant myelopoiesis

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NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

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Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

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T-bet and Eomes govern differentiation and function of mouse and human NK cells and ILC1

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T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate

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Prognostic significance of tumor-infiltrating lymphocytes in nondisseminated nasopharyngeal carcinoma: A large-scale cohort study

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Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742)

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Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study

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(2018) Diether Lambrechts et al.   NATURE MEDICINE

Camrelizumab (SHR-1210) alone or in combination with gemcitabine plus cisplatin for nasopharyngeal carcinoma: results from two single-arm, phase 1 trials

(2018) Wenfeng Fang et al.   LANCET ONCOLOGY

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

(2018) Hanjie Li et al.   CELL

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

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Single-cell reconstruction of the early maternal–fetal interface in humans

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Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1–Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Study

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Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-Based Subtypes

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Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

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Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

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Coinhibitory Pathways in Immunotherapy for Cancer

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Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy

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Single‐cell sequencing maps gene expression to mutational phylogenies in PDGF‐ and EGF‐driven gliomas

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Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

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Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

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Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

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Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

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Defining cell types and states with single-cell genomics

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Comprehensive genomic characterization of head and neck squamous cell carcinomas

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Posttranscriptional silencing of the lncRNA MALAT1 by miR-217 inhibits the epithelial–mesenchymal transition via enhancer of zeste homolog 2 in the malignant transformation of HBE cells induced by cigarette smoke extract

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CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

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Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

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Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression

(2014) Manesh Chittezhath et al.   IMMUNITY

NFATc1 Regulates PD-1 Expression upon T Cell Activation

(2014) K. J. Oestreich et al.   JOURNAL OF IMMUNOLOGY

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

The genomic landscape of nasopharyngeal carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

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GSVA: gene set variation analysis for microarray and RNA-Seq data

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The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

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The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice

(2012) Salvador Iborra et al.   JOURNAL OF CLINICAL INVESTIGATION

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Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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Discriminating gene expression profiles of memory B cell subpopulations

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