Lighting-up aptamer transcriptional amplification for highly sensitive and label-free FEN1 detection

Functional Aptamer-Embedded Nanomaterials for Diagnostics and Therapeutics

(2021) Sitao Xie et al.   ACS Applied Materials & Interfaces

Fluorometric detection of cancer marker FEN1 based on double-flapped dumbbell DNA nanoprobe functionalized with silver nanoclusters

(2021) Bingzhi Li et al.   ANALYTICA CHIMICA ACTA

Signal-Amplified Detection of the Tumor Biomarker FEN1 Based on Cleavage-Induced Ligation of a Dumbbell DNA Probe and Rolling Circle Amplification

(2021) Bingzhi Li et al.   ANALYTICAL CHEMISTRY

Fluorescent Assay of FEN1 Activity with Nicking Enzyme-Assisted Signal Amplification Based on ZIF-8 for Imaging in Living Cells

(2021) Yunfei Tang et al.   ANALYTICAL CHEMISTRY

Dual-Mode FEN1 Activity Detection Based on Nt.BstNBI-Induced Tandem Signal Amplification

(2021) Haitang Yang et al.   ANALYTICAL CHEMISTRY

Precision Spherical Nucleic Acids Enable Sensitive FEN1 Imaging and Controllable Drug Delivery for Cancer-Specific Therapy

(2021) Shuang Li et al.   ANALYTICAL CHEMISTRY

Exponential amplification reaction-based fluorescent sensor for the sensitive detection of tumor biomarker flap endonuclease 1

(2021) Bin Zhou et al.   SENSORS AND ACTUATORS B-CHEMICAL

A magnetic separation-assisted cascade hybridization chain reaction amplification strategy for sensitive detection of flap endonuclease 1

(2021) Liyan Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Aptamers used for biosensors and targeted therapy

(2020) Yi Ning et al.   BIOMEDICINE & PHARMACOTHERAPY

Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells

(2019) Long Ma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cascade Transcription Amplification of RNA aptamer (RACTA) for Ultrasensitive MicroRNA Detection

(2019) Mengxi Zhou et al.   ANALYTICAL CHEMISTRY

Lighting-up RNA aptamer transcription synchronization amplification for ultrasensitive and label-free imaging of microRNA in single cells

(2019) Daxiu Li et al.   ANALYTICA CHIMICA ACTA

Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non–Small-Cell Lung Cancer

(2018) Keqiang Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Amplified Tandem Spinach-based Aptamer Transcription Enables Low Background miRNA Detection

(2018) Xin Tang et al.   ANALYTICAL CHEMISTRY

A conserved loop–wedge motif moderates reaction site search and recognition by FEN1

(2018) Mark J Thompson et al.   NUCLEIC ACIDS RESEARCH

Labeling RNAs in Live Cells Using Malachite Green Aptamer Scaffolds as Fluorescent Probes

(2018) V. Siddartha Yerramilli et al.   ACS Synthetic Biology

Flap Endonuclease 1 Mutations A159V and E160D Cause Genomic Instability by Slowing Reaction on Double-Flap Substrates

(2018) Sana I. Algasaier et al.   BIOCHEMISTRY

Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems

(2018) Hao Zhang et al.   NANO LETTERS

Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1

(2018) Hong Xu et al.   NUCLEIC ACIDS RESEARCH

Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening

(2017) Amit Laxmikant Deshmukh et al.   Molecular BioSystems

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis

(2014) KEJIA WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice

(2011) Zhenxing Wu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

An Alternative Pathway for Okazaki Fragment Processing

(2010) Jason E. Pike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

Label-Free Fluorescent Aptamer Sensor Based on Regulation of Malachite Green Fluorescence

(2009) Weichen Xu et al.   ANALYTICAL CHEMISTRY

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

(2008) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY