Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening

Investigation of human flap structure-specific endonuclease 1 (FEN1) activity on primer-template models and exploration of a substrate-based FEN1 inhibitor

(2016) Sai Ba et al.   BIOORGANIC & MEDICINAL CHEMISTRY

QSAR and Docking Studies of N-hydroxy Urea Derivatives as Flap Endonuclease-1 Inhibitors

(2016) Pankaj Wadhwa et al.   Current Computer-Aided Drug Design

Dynamics of replication proteins during lagging strand synthesis: A crossroads for genomic instability and cancer

(2016) Amit Laxmikant Deshmukh et al.   DNA REPAIR

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

(2016) Jack C Exell et al.   Nature Chemical Biology

Synthetic modified pyrrolo[1,4] benzodiazepine molecules demonstrate selective anticancer activity by targeting the human ligase 1 enzyme: An in silico and in vitro mechanistic study

(2015) Mohammad Shameem et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Okazaki fragment maturation involves  -segment error editing by the mammalian FEN1/MutS  functional complex

(2015) S. Liu et al.   EMBO JOURNAL

Pharmacophore-Based Screening and Identification of Novel Human Ligase I Inhibitors with Potential Anticancer Activity

(2014) Shagun Krishna et al.   Journal of Chemical Information and Modeling

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate

(2014) M. Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The influence of negative training set size on machine learning-based virtual screening

(2014) Rafał Kurczab et al.   Journal of Cheminformatics

Comparison of Confirmed Inactive and Randomly Selected Compounds as Negative Training Examples in Support Vector Machine-Based Virtual Screening

(2013) Kathrin Heikamp et al.   Journal of Chemical Information and Modeling

An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

(2013) Derek M. van Pel et al.   PLoS Genetics

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer

(2011) L. Liu et al.   CARCINOGENESIS

Prediction of protein secondary structure from circular dichroism using theoretically derived spectra

(2011) Caroline Louis-Jeune et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

PaDEL-descriptor: An open source software to calculate molecular descriptors and fingerprints

(2010) Chun Wei Yap   JOURNAL OF COMPUTATIONAL CHEMISTRY

Spectroscopic Probing of the Microenvironment in a Protein−Surfactant Assembly

(2010) Uttam Anand et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

(2010) Dorjbal Dorjsuren et al.   NUCLEIC ACIDS RESEARCH

FunctionalFEN1polymorphisms are associated with DNA damage levels and lung cancer risk

(2009) Ming Yang et al.   HUMAN MUTATION

PubChem: a public information system for analyzing bioactivities of small molecules

(2009) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Early-Onset Lymphoma and Extensive Embryonic Apoptosis in Two Domain-Specific Fen1 Mice Mutants

(2008) E. Larsen et al.   CANCER RESEARCH