Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
Authors
Keywords
-
Journal
Journal of Hematology & Oncology
Volume 15, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-07-07
DOI
10.1186/s13045-022-01307-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
- (2022) Emeric Limagne et al. CANCER CELL
- Genomic features and tumor immune microenvironment alteration in NSCLC treated with neoadjuvant PD-1 blockade
- (2022) Shuhang Wang et al. npj Precision Oncology
- Tumor-derived extracellular vesicles inhibit HGF/c-Met and EGF/EGFR pathways to accelerate the radiosensitivity of nasopharyngeal carcinoma cells via microRNA-142-5p delivery
- (2022) Changyu Zhu et al. Cell Death Discovery
- Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation
- (2022) Mengling Wu et al. Journal of Hematology & Oncology
- Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma
- (2022) Samuel Chuah et al. JOURNAL OF HEPATOLOGY
- Rgs16 promotes antitumor CD8 + T cell exhaustion
- (2022) Nina Weisshaar et al. Science Immunology
- Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities
- (2022) Tae Kon Kim et al. NATURE REVIEWS DRUG DISCOVERY
- The effects of stereotactic body radiotherapy on peripheral natural killer and CD3+CD56+ NKT-like cells in patients with hepatocellular carcinoma
- (2021) Tian-Tian Li et al. Hepatobiliary & Pancreatic Diseases International
- Autocrine TGF-β in Cancer: Review of the Literature and Caveats in Experimental Analysis
- (2021) Hendrik Ungefroren INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- IMbrave150: Updated overall survival (OS) data from a global, randomized, open-label phase III study of atezolizumab (atezo) + bevacizumab (bev) versus sorafenib (sor) in patients (pts) with unresectable hepatocellular carcinoma (HCC).
- (2021) Richard S. Finn et al. JOURNAL OF CLINICAL ONCOLOGY
- Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
- (2021) Jiali Yu et al. NATURE MEDICINE
- Stereotactic Body Radiotherapy Is Effective in Modifying the Tumor Genome and Tumor Immune Microenvironment in Non-Small Cell Lung Cancer or Lung Metastatic Carcinoma
- (2021) Pu Zhou et al. Frontiers in Immunology
- A randomized trial of adjuvant chemotherapy versus observation in patients with nasopharyngeal carcinoma with detectable post-radiotherapy pEBV DNA
- (2021) Edwin Pun Hui et al. CLINICAL CANCER RESEARCH
- Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion
- (2021) Wooseok Seo et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity
- (2021) Yuzhu Hou et al. Science Translational Medicine
- Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma
- (2021) Lanqi Gong et al. Nature Communications
- Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution
- (2021) Yang Liu et al. Nature Communications
- Changes in the Peripheral Blood Treg Cell Proportion in Hepatocellular Carcinoma Patients After Transarterial Chemoembolization With Microparticles
- (2021) Zhizhong Ren et al. Frontiers in Immunology
- Patients With Short PFS to EGFR-TKIs Predicted Better Response to Subsequent Anti-PD-1/PD-L1 Based Immunotherapy in EGFR Common Mutation NSCLC
- (2021) Sangtian Liu et al. Frontiers in Oncology
- Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity
- (2021) N.E. Donlon et al. CANCER LETTERS
- Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets
- (2021) Xiang-Yuan Luo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
- (2021) Kai Tang et al. Journal of Hematology & Oncology
- Next generation of immune checkpoint inhibitors and beyond
- (2021) Julian A. Marin-Acevedo et al. Journal of Hematology & Oncology
- NASH limits anti-tumour surveillance in immunotherapy-treated HCC
- (2021) Dominik Pfister et al. NATURE
- Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
- (2021) Evan W. Weber et al. SCIENCE
- A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
- (2021) Weiqin Yang et al. Science Translational Medicine
- Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
- (2021) Nathalie M. Schmidt et al. Nature Communications
- The Next Decade of Immune Checkpoint Therapy
- (2021) Padmanee Sharma et al. Cancer Discovery
- Efficacy and tolerability of immunotherapy in advanced nasopharyngeal carcinoma with or without chemotherapy: a meta-analysis
- (2021) Lifeng Xiao et al. Brazilian Journal of Otorhinolaryngology
- A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma
- (2021) Chaofei Xia et al. Frontiers in Immunology
- Complete response to PD-1 blockade following EBV-specific T-cell therapy in metastatic nasopharyngeal carcinoma
- (2021) Corey Smith et al. npj Precision Oncology
- Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion
- (2021) Yan Lan et al. CANCER CELL
- Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases
- (2021) Inna Smalley et al. CLINICAL CANCER RESEARCH
- Neutrophil–Lymphocyte Ratio and Absolute Lymphocyte Count as Prognostic Markers in Patients Treated with Curative-intent Radiotherapy for Non-small Cell Lung Cancer
- (2021) A. Punjabi et al. CLINICAL ONCOLOGY
- Lenvatinib Targets FGF Receptor 4 to Enhance Antitumor Immune Response of Anti–Programmed Cell Death‐1 in HCC
- (2021) Chenhe Yi et al. HEPATOLOGY
- Applications of single-cell sequencing in cancer research: progress and perspectives
- (2021) Yalan Lei et al. Journal of Hematology & Oncology
- Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response
- (2021) Tong Fu et al. Journal of Hematology & Oncology
- Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B
- (2021) Yanan Gao et al. JOURNAL OF HEPATOLOGY
- Regulatory T cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis
- (2021) Han Wang et al. JOURNAL OF HEPATOLOGY
- Treatment-related adverse events of PD-1 and PD-L1 inhibitor-based combination therapies in clinical trials: a systematic review and meta-analysis
- (2021) Xiaoxiang Zhou et al. LANCET ONCOLOGY
- Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
- (2021) Justina X. Caushi et al. NATURE
- Exploring tissue architecture using spatial transcriptomics
- (2021) Anjali Rao et al. NATURE
- Toward personalized treatment approaches for non-small-cell lung cancer
- (2021) Meina Wang et al. NATURE MEDICINE
- Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial
- (2021) Hai-Qiang Mai et al. NATURE MEDICINE
- Spatial omics and multiplexed imaging to explore cancer biology
- (2021) Sabrina M. Lewis et al. NATURE METHODS
- Selecting the optimal immunotherapy regimen in driver-negative metastatic NSCLC
- (2021) Michael J. Grant et al. Nature Reviews Clinical Oncology
- Cancer stem cells in hepatocellular carcinoma — from origin to clinical implications
- (2021) Terence Kin-Wah Lee et al. Nature Reviews Gastroenterology & Hepatology
- Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics
- (2021) Sophia K. Longo et al. NATURE REVIEWS GENETICS
- Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models
- (2021) Amaia Martinez-Usatorre et al. Science Translational Medicine
- Changes in T Lymphocyte Subsets in Different Tumors Before and After Radiotherapy: A Meta-analysis
- (2021) Qin Wang et al. Frontiers in Immunology
- Impact of high-dose rate radiotherapy on B and natural killer (NK) cell polarization in peripheral blood mononuclear cells (PBMCs) via inducing non-small cell lung cancer (NSCLC)-derived exosomes
- (2021) Qian-Qian Lei et al. Translational Cancer Research
- Pembrolizumab-induced cytokine release syndrome in a patient with metastatic lung adenocarcinoma: a case report
- (2021) Paul Sackstein et al. Journal for ImmunoTherapy of Cancer
- PD-1+CXCR5−CD4+ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma
- (2021) Jiang-Ping Li et al. Journal for ImmunoTherapy of Cancer
- Radiotherapy Combined with PD-1 Inhibition Increases NK Cell Cytotoxicity towards Nasopharyngeal Carcinoma Cells
- (2021) Anna Makowska et al. Cells
- The Stromal and Immune Landscape of Nasopharyngeal Carcinoma and Its Implications for Precision Medicine Targeting the Tumor Microenvironment
- (2021) Lanqi Gong et al. Frontiers in Oncology
- Genetic Variations in the Transforming Growth Factor-β1 Pathway May Improve Predictive Power for Overall Survival in Non-small Cell Lung Cancer
- (2021) Hong Zhang et al. Frontiers in Oncology
- Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis
- (2021) Feng Wu et al. CANCER LETTERS
- Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update
- (2021) Bryan J. Schneider et al. JOURNAL OF CLINICAL ONCOLOGY
- Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes
- (2021) Wantao Wu et al. Journal of Hematology & Oncology
- P21.01 Selected ctDNA Panel Gene Sequencing for Neoantigen Discovery and Survival Prediction in Patients With Stage IV Non-Small Cell Lung Cancer
- (2021) Y. Zhang et al. Journal of Thoracic Oncology
- Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment
- (2021) James L. Gulley et al. Molecular Oncology
- Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
- (2021) Dora Hammerl et al. Nature Communications
- Prognostic Role of Soluble Programmed Death Ligand 1 in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
- (2021) Guixiang Liao et al. Frontiers in Oncology
- CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma
- (2020) Yurong Gu et al. Aging-US
- A review of cancer immunotherapy toxicity
- (2020) Lucy Boyce Kennedy et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal cancer
- (2020) Jin Zhao et al. CANCER LETTERS
- Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation–Positive Non–Small Cell Lung Cancer
- (2020) Kohsuke Isomoto et al. CLINICAL CANCER RESEARCH
- Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation?
- (2020) Liam Masterson et al. INTERNATIONAL JOURNAL OF CANCER
- Single-cell transcriptome analysis reveals TOX as a promoting factor for T cell exhaustion and a predictor for anti-PD-1 responses in human cancer
- (2020) Kyungsoo Kim et al. Genome Medicine
- Response and outcomes after anti-CTLA4 versus anti-PD1 combined with stereotactic body radiation therapy for metastatic non-small cell lung cancer: retrospective analysis of two single-institution prospective trials
- (2020) Dawei Chen et al. Journal for ImmunoTherapy of Cancer
- Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances
- (2020) Hanne Lind et al. Journal for ImmunoTherapy of Cancer
- Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes
- (2020) Ekaterina Friebel et al. CELL
- RNA m 6 A methylation regulates sorafenib resistance in liver cancer through FOXO 3‐mediated autophagy
- (2020) Ziyou Lin et al. EMBO JOURNAL
- Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
- (2020) Jean-Christophe Beltra et al. IMMUNITY
- Radiation-enhanced expression of CCL22 in nasopharyngeal carcinoma is associated with CCR4+ CD8 T cell recruitment
- (2020) Hanghang Li et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Comprehensive immune cell analysis from lung cancer patients with PD-1 inhibitor neoadjuvant immunotherapy using single cell sequencing.
- (2020) Zhenzhen Hui et al. JOURNAL OF CLINICAL ONCOLOGY
- Emerging agents that target signaling pathways in cancer stem cells
- (2020) Yue Yang et al. Journal of Hematology & Oncology
- Atezolizumab plus Bevacizumab — A Landmark in Liver Cancer
- (2020) Robin K. Kelley NEW ENGLAND JOURNAL OF MEDICINE
- Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma
- (2020) Richard S. Finn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Elevated IL18 levels in Nasopharyngeal carcinoma induced PD-1 expression on NK cells in TILS leading to poor prognosis
- (2020) Anthony Kian-Fong Liou et al. ORAL ONCOLOGY
- Trajectory and Functional Analysis of PD‐1 high CD4 + CD8 + T Cells in Hepatocellular Carcinoma by Single‐Cell Cytometry and Transcriptome Sequencing
- (2020) Bo Zheng et al. Advanced Science
- Progress and Challenges in Precise Treatment of Tumors With PD-1/PD-L1 Blockade
- (2020) Youhai Jiang et al. Frontiers in Immunology
- Anti-PD-1 antibody increases NK cell cytotoxicity towards nasopharyngeal carcinoma cells in the context of chemotherapy-induced upregulation of PD-1 and PD-L1
- (2020) Anna Makowska et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Dynamics of peripheral T cell clones during PD-1 blockade in non-small cell lung cancer
- (2020) Fan Zhang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Chemotherapy negatively impacts the tumor immune microenvironment in NSCLC: an analysis of pre- and post-treatment biopsies in the multi-center SAKK19/09 study
- (2020) M. A. Amrein et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
- (2020) Yu-Pei Chen et al. CELL RESEARCH
- SBRT combined with PD-1/PD-L1 inhibitors in NSCLC treatment: a focus on the mechanisms, advances, and future challenges
- (2020) Yu Chen et al. Journal of Hematology & Oncology
- Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer
- (2020) Chia-Sing Lu et al. Journal of Hematology & Oncology
- NK cells and ILCs in tumor immunotherapy
- (2020) Simona Sivori et al. MOLECULAR ASPECTS OF MEDICINE
- TGFβ biology in cancer progression and immunotherapy
- (2020) Rik Derynck et al. Nature Reviews Clinical Oncology
- Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses
- (2020) Karsten A. Pilones et al. Cancer Immunology Research
- Clarification of Definitions of Hyperprogressive Disease During Immunotherapy for Non–Small Cell Lung Cancer
- (2020) Baptiste Kas et al. JAMA Oncology
- IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma
- (2020) Wenjie Zhang et al. Journal for ImmunoTherapy of Cancer
- The Role of Tumor-Associated Myeloid Cells in Modulating Cancer Therapy
- (2020) Christiana M. Neophytou et al. Frontiers in Oncology
- An esophageal cancer case of cytokine release syndrome with multiple-organ injury induced by an anti-PD-1 drug: a case report
- (2020) Chao Gao et al. Annals of Palliative Medicine
- Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing
- (2020) Ashley Maynard et al. CELL
- Circulating T-cell Immunosenescence in Patients with Advanced Non–small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy
- (2020) Roberto Ferrara et al. CLINICAL CANCER RESEARCH
- Soluble PD-L1 and Circulating CD8+PD-1+ and NK Cells Enclose a Prognostic and Predictive Immune Effector Score in Immunotherapy Treated NSCLC patients
- (2020) G. Mazzaschi et al. LUNG CANCER
- A pan-cancer analysis of PD-L1 immunohistochemistry and gene amplification, tumor mutation burden and microsatellite instability in 48,782 cases
- (2020) Richard S. P. Huang et al. MODERN PATHOLOGY
- Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook
- (2020) Lena Horvath et al. Molecular Cancer
- PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
- (2020) Qi Peng et al. Nature Communications
- Impacts of post‐radiotherapy lymphocyte count on progression‐free and overall survival in patients with stage III lung cancer
- (2020) Juliana Matiello et al. Thoracic Cancer
- IDO Expression in Cancer: Different Compartment, Different Functionality?
- (2020) Annabel Meireson et al. Frontiers in Immunology
- CD44, a marker of cancer stem cells, is positively correlated with PD-L1 expression and immune cells infiltration in lung adenocarcinoma
- (2020) Chenyue Zhang et al. Cancer Cell International
- ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma
- (2020) Yuta Myojin et al. CLINICAL CANCER RESEARCH
- High-affinity neoantigens correlate with better prognosis and trigger potent antihepatocellular carcinoma (HCC) activity by activating CD39+CD8+ T cells
- (2020) Ting Liu et al. GUT
- Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy
- (2020) Satyen H. Gohil et al. Nature Reviews Clinical Oncology
- PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells
- (2020) Camille-Charlotte Balança et al. JCI Insight
- Understanding tumour cell heterogeneity and its implication for immunotherapy in liver cancer using single-cell analysis
- (2020) Sophia Heinrich et al. JOURNAL OF HEPATOLOGY
- Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
- (2019) Jérôme Galon et al. NATURE REVIEWS DRUG DISCOVERY
- Lymphopenia in Cancer Patients and its Effects on Response to Immunotherapy: an opportunity for combination with Cytokines?
- (2019) Christine Ménétrier-Caux et al. Journal for ImmunoTherapy of Cancer
- α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas
- (2019) E. Dodagatta-Marri et al. Journal for ImmunoTherapy of Cancer
- Impact of Radiotherapy Concurrent with Anti-PD-1 Therapy on the Lung Tissue of Tumor-Bearing Mice
- (2019) Feng Wang et al. RADIATION RESEARCH
- Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma
- (2019) Michael Teufel et al. GASTROENTEROLOGY
- Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance
- (2019) Filipe Martins et al. Nature Reviews Clinical Oncology
- Hepatocellular Carcinoma
- (2019) Augusto Villanueva NEW ENGLAND JOURNAL OF MEDICINE
- PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
- (2019) Takahiro Kamada et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses
- (2019) Daisuke Sugiura et al. SCIENCE
- PD-1 Immune Checkpoint Inhibitors and Immune-Related Adverse Events
- (2019) Diwakar Davar et al. JAMA Oncology
- BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
- (2019) Clotilde Wiel et al. CELL
- TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
- (2019) Yang Hao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study
- (2019) Edward B. Garon et al. JOURNAL OF CLINICAL ONCOLOGY
- Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer
- (2019) James Clarke et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TOX is a critical regulator of tumour-specific T cell differentiation
- (2019) Andrew C. Scott et al. NATURE
- TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
- (2019) Omar Khan et al. NATURE
- Clonal replacement of tumor-specific T cells following PD-1 blockade
- (2019) Kathryn E. Yost et al. NATURE MEDICINE
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
- (2019) Hyungseok Seo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crizotinib-induced immunogenic cell death in non-small cell lung cancer
- (2019) Peng Liu et al. Nature Communications
- HIF-1α-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib
- (2019) Zhen Song et al. CANCER LETTERS
- A Validation Study on IDO Immune Biomarkers for Survival Prediction in Non-small Cell Lung Cancer: Radiation Dose Fractionation Effect in Early Stage Disease
- (2019) Weili Wang et al. CLINICAL CANCER RESEARCH
- Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation
- (2019) Jianzhou Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Immune checkpoint inhibitors of PD-L1 as cancer therapeutics
- (2019) Akintunde Akinleye et al. Journal of Hematology & Oncology
- Heterogeneity of PD-L1 expression in non-small cell lung cancer: Implications for specimen sampling in predicting treatment response
- (2019) Alexander Haragan et al. LUNG CANCER
- Interferon β and Anti-PD-1/PD-L1 Checkpoint Blockade Cooperate in NK Cell-Mediated Killing of Nasopharyngeal Carcinoma Cells
- (2019) Anna Makowska et al. Translational Oncology
- 1483PDPembrolizumab (pembro) plus platinum-based chemotherapy (chemo) in NSCLC with brain metastases: Pooled analysis of KEYNOTE-021, 189, and 407
- (2019) S F Powell et al. ANNALS OF ONCOLOGY
- Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4
- (2019) Shuang Qin et al. Molecular Cancer
- TCR Repertoire Diversity of Peripheral PD-1+CD8+ T Cells Predicts Clinical Outcomes after Immunotherapy in Patients with Non–Small Cell Lung Cancer
- (2019) Jiefei Han et al. Cancer Immunology Research
- Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update
- (2019) Joseph A. Clara et al. Nature Reviews Clinical Oncology
- Use of Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer
- (2019) Jianchun Duan et al. JAMA Oncology
- Osimertinib and other third-generation EGFR TKI in EGFR-mutant NSCLC patients
- (2018) J Remon et al. ANNALS OF ONCOLOGY
- First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
- (2018) Rizwan Romee et al. BLOOD
- TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association
- (2018) Justin Zonneville et al. BMC CANCER
- PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC
- (2018) Marzia Del Re et al. BRITISH JOURNAL OF CANCER
- Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression
- (2018) Yanmei Han et al. CELL
- Soluble Programmed Cell Death Ligand 1 as a Novel Biomarker for Nivolumab Therapy for Non–Small-cell Lung Cancer
- (2018) Yusuke Okuma et al. Clinical Lung Cancer
- Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer
- (2018) Clemens Grassberger et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Concurrent Immune Checkpoint Inhibitors and Stereotactic Radiosurgery for Brain Metastases in Non-Small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma
- (2018) Linda Chen et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Five-Year Follow-Up of Nivolumab in Previously Treated Advanced Non–Small-Cell Lung Cancer: Results From the CA209-003 Study
- (2018) Scott Gettinger et al. JOURNAL OF CLINICAL ONCOLOGY
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Role of PD-1 during effector CD8 T cell differentiation
- (2018) Eunseon Ahn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical significance of soluble programmed cell death ligand-1 (sPD-L1) in hepatocellular carcinoma patients treated with radiotherapy
- (2018) Hyun Ju Kim et al. RADIOTHERAPY AND ONCOLOGY
- Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β
- (2018) Yan Lan et al. Science Translational Medicine
- Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect
- (2018) María E. Rodríguez-Ruiz et al. TRENDS IN IMMUNOLOGY
- Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
- (2018) Marco B. Schaaf et al. Cell Death & Disease
- STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
- (2018) Jung-Mao Hsu et al. Nature Communications
- CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-L1 blockade
- (2018) Limo Chen et al. Cancer Discovery
- Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
- (2018) Andrea Botticelli et al. Journal of Translational Medicine
- Camrelizumab (SHR-1210) alone or in combination with gemcitabine plus cisplatin for nasopharyngeal carcinoma: results from two single-arm, phase 1 trials
- (2018) Wenfeng Fang et al. LANCET ONCOLOGY
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- Autocrine TGFβ is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment
- (2018) Alba Gonzalez-Junca et al. Cancer Immunology Research
- Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion
- (2018) Linsen Ye et al. Journal for ImmunoTherapy of Cancer
- Atezolizumab in patients with advanced non-small cell lung cancer and history of asymptomatic, treated brain metastases: Exploratory analyses of the phase III OAK study
- (2018) Shirish M. Gadgeel et al. LUNG CANCER
- Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
- (2018) Giuseppe Lo Russo et al. CLINICAL CANCER RESEARCH
- Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas
- (2017) Guoying Zhou et al. GASTROENTEROLOGY
- High numbers of myeloid derived suppressor cells in peripheral blood and ascitic fluid of cirrhotic and HCC patients
- (2017) Nadia Elwan et al. IMMUNOLOGICAL INVESTIGATIONS
- Plasma Levels of IL-8 and TGF-β1 Predict Radiation-Induced Lung Toxicity in Non-Small Cell Lung Cancer: A Validation Study
- (2017) Shulian Wang et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China
- (2017) Si-Yang Liu et al. Journal of Hematology & Oncology
- Combined Radiotherapy and Anti–PD-L1 Antibody Synergistically Enhances Antitumor Effect in Non–Small Cell Lung Cancer
- (2017) Xiaomei Gong et al. Journal of Thoracic Oncology
- Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
- (2017) Shabnam Shalapour et al. NATURE
- Elements of cancer immunity and the cancer–immune set point
- (2017) Daniel S. Chen et al. NATURE
- Severe cytokine release syndrome in a patient receiving PD-1-directed therapy
- (2017) Seth J. Rotz et al. PEDIATRIC BLOOD & CANCER
- Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients
- (2017) Alice O. Kamphorst et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
- (2017) Florie Bertrand et al. Nature Communications
- Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model
- (2017) Kyoung-Jin Kim et al. Oncotarget
- High BMI1 mRNA expression in peripheral whole blood is associated with favorable prognosis in advanced non-small cell lung cancer patients
- (2017) Ana Koren et al. Oncotarget
- Radiotherapy for Non-Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues
- (2016) S. Siva et al. CLINICAL CANCER RESEARCH
- High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis
- (2016) Fabian Finkelmeier et al. EUROPEAN JOURNAL OF CANCER
- Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
- (2016) Shao-Lai Zhou et al. GASTROENTEROLOGY
- Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma
- (2016) Aparna Jayachandran et al. Journal of Hematology & Oncology
- P2.36: Nivolumab (nivo) in Patients (pts) With Advanced (adv) NSCLC and Central Nervous System (CNS) Metastases (mets)
- (2016) Jonathan W. Goldman et al. Journal of Thoracic Oncology
- PD-L1 on peripheral blood T lymphocytes is prognostic in patients with non-small cell lung cancer (NSCLC) treated with EGFR inhibitors
- (2016) Tarek M. Meniawy et al. LUNG CANCER
- NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
- (2016) Chi Ma et al. NATURE
- Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
- (2016) Se Jin Im et al. NATURE
- Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
- (2016) K. E. Pauken et al. SCIENCE
- miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
- (2016) Mengyang Zhao et al. Nature Communications
- Comments on “NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis”
- (2016) Guangbing Li et al. HEPATOBILIARY SURGERY AND NUTRITION
- The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy
- (2015) Lijie Zhai et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
- (2015) Kevin C. Conlon et al. JOURNAL OF CLINICAL ONCOLOGY
- The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities
- (2015) Daniel J. Silver et al. NEURO-ONCOLOGY
- Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
- (2015) N. A. Rizvi et al. SCIENCE
- Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity
- (2015) Feng-Ming (Spring) Kong et al. SEMINARS IN RADIATION ONCOLOGY
- TGF -Driven Stem Cell Heterogeneity Underlies Drug Resistance in SCC
- (2015) Cancer Discovery
- Tracking viable circulating tumor cells (CTCs) in the peripheral blood of non-small cell lung cancer (NSCLC) patients undergoing definitive radiation therapy: Pilot study results
- (2014) Jay F. Dorsey et al. CANCER
- Distinct Subpopulations of Head and Neck Cancer Cells with Different Levels of Intracellular Reactive Oxygen Species Exhibit Diverse Stemness, Proliferation, and Chemosensitivity
- (2014) C.-W. Chang et al. CANCER RESEARCH
- Redox Proteins and Radiotherapy
- (2014) Y. Zhang et al. CLINICAL ONCOLOGY
- Cancer stem cells and radioresistance
- (2014) Kiera Rycaj et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Complement Receptor 1 Expression in Peripheral Blood Mononuclear Cells and the Association with Clinicopathological Features And Prognosis of Nasopharyngeal Carcinoma
- (2013) Jian-Rong He et al. Asian Pacific Journal of Cancer Prevention
- Oncology Meets Immunology: The Cancer-Immunity Cycle
- (2013) Daniel S. Chen et al. IMMUNITY
- PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
- (2013) Erin E. West et al. JOURNAL OF CLINICAL INVESTIGATION
- Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
- (2013) Rikke B. Holmgaard et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Immune Responses following Stereotactic Body Radiotherapy for Stage I Primary Lung Cancer
- (2013) Yoshiyasu Maehata et al. Biomed Research International
- Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway
- (2012) Vesselina G. Cooke et al. CANCER CELL
- Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy
- (2012) Y. Jin et al. EUROPEAN JOURNAL OF CANCER
- Artemin Stimulates Radio- and Chemo-resistance by Promoting TWIST1-BCL-2-dependent Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells
- (2012) Arindam Banerjee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Breast-cancer stem cells—beyond semantics
- (2012) Sunil Badve et al. LANCET ONCOLOGY
- Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2fraction
- (2011) Osama Al-Assar et al. CANCER BIOLOGY & THERAPY
- Metastatic Cells Will Take Any Help They Can Get
- (2011) Richard O. Hynes CANCER CELL
- MMP-9 expression in peripheral blood mononuclear cells and the association with clinicopathological features and prognosis of nasopharyngeal carcinoma
- (2011) Jian-Rong He et al. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- The expression of HIF-1α in primary hepatocellular carcinoma and its correlation with radiotherapy response and clinical outcome
- (2011) Zuo-Lin Xiang et al. MOLECULAR BIOLOGY REPORTS
- Radioresistant head and neck squamous cell carcinoma cells: Intracellular signaling, putative biomarkers for tumor recurrences and possible therapeutic targets
- (2011) Sergej Skvortsov et al. RADIOTHERAPY AND ONCOLOGY
- Low-dose Cyclophosphamide Treatment Impairs Regulatory T Cells and Unmasks AFP-specific CD4+ T-cell Responses in Patients With Advanced HCC
- (2010) Tim F. Greten et al. JOURNAL OF IMMUNOTHERAPY
- Changes of Circulating Transforming Growth Factor-²1 Level During Radiation Therapy Are Correlated with the Prognosis of Locally Advanced Non-small Cell Lung Cancer
- (2010) Lujun Zhao et al. Journal of Thoracic Oncology
- Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of Significance
- (2010) Nathan Moore et al. Journal of Oncology
- The Prevalence of FOXP3+ Regulatory T-Cells in Peripheral Blood of Patients with NSCLC
- (2009) Liu Li et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now