Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity
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Title
Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity
Authors
Keywords
Radiotherapy, Immunotherapy, Abscopal effect, Immunogenic cell death, DAMPS, Hypofractionation
Journal
CANCER LETTERS
Volume 502, Issue -, Pages 84-96
Publisher
Elsevier BV
Online
2021-01-13
DOI
10.1016/j.canlet.2020.12.045
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Note: Only part of the references are listed.- Combining microenvironment normalization strategies to improve cancer immunotherapy
- (2020) Fotios Mpekris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD73 blockade promotes dendritic cell infiltration of irradiated tumors and tumor rejection
- (2020) Erik Wennerberg et al. Cancer Immunology Research
- The Role of Cancer Stem Cells in Radiation Resistance
- (2020) Christoph Reinhold Arnold et al. Frontiers in Oncology
- Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma
- (2020) Richard S. Finn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lenvatinib plus pembrolizumab in patients with advanced gastric cancer in the first-line or second-line setting (EPOC1706): an open-label, single-arm, phase 2 trial
- (2020) Akihito Kawazoe et al. LANCET ONCOLOGY
- LBA41 LEAP-005: Phase II study of lenvatinib (len) plus pembrolizumab (pembro) in patients (pts) with previously treated advanced solid tumours
- (2020) Z. Lwin et al. ANNALS OF ONCOLOGY
- Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells
- (2020) Demet Candas-Green et al. Nature Communications
- Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
- (2019) Jérôme Galon et al. NATURE REVIEWS DRUG DISCOVERY
- Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?
- (2019) Ruben S. A. Goedegebuure et al. Frontiers in Immunology
- CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance
- (2019) Michele Mondini et al. Cancer Immunology Research
- Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer
- (2019) Triparna Sen et al. Cancer Discovery
- The increased adhesion of tumor cells to endothelial cells after irradiation can be reduced by FAK-inhibition
- (2019) Pascaline Nguemgo Kouam et al. Radiation Oncology
- Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial
- (2019) Vicky Makker et al. LANCET ONCOLOGY
- ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment
- (2019) Magnus T. Dillon et al. CLINICAL CANCER RESEARCH
- Cancer-associated fibroblasts in radiotherapy: challenges and new opportunities
- (2019) Zhanhuai Wang et al. Cell Communication and Signaling
- Understanding heterogeneous tumor microenvironment in metastatic melanoma
- (2019) Yiyi Yan et al. PLoS One
- Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition
- (2019) Priya Patel et al. OncoImmunology
- Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade
- (2019) Joseph L. Benci et al. CELL
- Cisplatin facilitates radiation-induced abscopal effects in conjunction with PD-1 checkpoint blockade through CXCR3/CXCL10-mediated T cell recruitment
- (2019) Ren Luo et al. CLINICAL CANCER RESEARCH
- Irradiation or temozolomide chemotherapy enhances anti-CD47 treatment of glioblastoma
- (2019) Sharareh Gholamin et al. Innate Immunity
- Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation
- (2019) Jianzhou Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Microenvironmental Heterogeneity in Brain Malignancies
- (2019) Lucas J. M. Perus et al. Frontiers in Immunology
- Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation
- (2019) Anthony L. Schwartz et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- cGAS/STING axis mediates a topoisomerase II inhibitor–induced tumor immunogenicity
- (2019) Zining Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Stereotactic Body Radiotherapy for Oligometastatic Disease in Non-small Cell Lung Cancer
- (2019) Caryn Wujanto et al. Frontiers in Oncology
- Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer
- (2018) Silvia C. Formenti et al. CLINICAL CANCER RESEARCH
- Dose-limiting Urinary Toxicity With Pembrolizumab Combined With Weekly Hypofractionated Radiation Therapy in Bladder Cancer
- (2018) Alison Claire Tree et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Increased vessel perfusion predicts the efficacy of immune checkpoint blockade
- (2018) Xichen Zheng et al. JOURNAL OF CLINICAL INVESTIGATION
- PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression
- (2018) Haidong Tang et al. JOURNAL OF CLINICAL INVESTIGATION
- Effects of various radiation doses on induced T-helper cell differentiation and related cytokine secretion
- (2018) Hui Gao et al. JOURNAL OF RADIATION RESEARCH
- Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs
- (2018) Julie M. Diamond et al. Cancer Immunology Research
- Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
- (2018) Yuzhu Hou et al. IMMUNITY
- ATR kinase inhibitor AZD6738 potentiates CD8+ T cell–dependent antitumor activity following radiation
- (2018) Frank P. Vendetti et al. JOURNAL OF CLINICAL INVESTIGATION
- Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
- (2018) Peng Jiang et al. NATURE MEDICINE
- Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
- (2018) Scott J. Antonia et al. NEW ENGLAND JOURNAL OF MEDICINE
- A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours
- (2018) Amit Maity et al. BRITISH JOURNAL OF CANCER
- Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response
- (2018) Assaf Marcus et al. IMMUNITY
- Radiotherapy induces responses of lung cancer to CTLA-4 blockade
- (2018) Silvia C. Formenti et al. NATURE MEDICINE
- State-of-the-art strategies for targeting the DNA damage response in cancer
- (2018) Patrick G. Pilié et al. Nature Reviews Clinical Oncology
- Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors
- (2018) David Argyle et al. Frontiers in Immunology
- The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
- (2017) Bertrand Allard et al. IMMUNOLOGICAL REVIEWS
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Mitotic progression following DNA damage enables pattern recognition within micronuclei
- (2017) Shane M. Harding et al. NATURE
- Elements of cancer immunity and the cancer–immune set point
- (2017) Daniel S. Chen et al. NATURE
- Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
- (2017) Lin Tian et al. NATURE
- Radiotherapy and immunotherapy: a beneficial liaison?
- (2017) Ralph R. Weichselbaum et al. Nature Reviews Clinical Oncology
- Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
- (2017) Hua Liang et al. Nature Communications
- DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
- (2017) Claire Vanpouille-Box et al. Nature Communications
- Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer
- (2017) Davinder Singh et al. Cell and Bioscience
- Barriers to Radiation-Induced In Situ Tumor Vaccination
- (2017) Erik Wennerberg et al. Frontiers in Immunology
- PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation
- (2017) Megan Morisada et al. OncoImmunology
- Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
- (2016) Joseph L. Benci et al. CELL
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma
- (2016) Anusha Kalbasi et al. CLINICAL CANCER RESEARCH
- Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer
- (2016) Eileen E. Parkes et al. JNCI-Journal of the National Cancer Institute
- Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei
- (2016) Magnus T. Dillon et al. MOLECULAR CANCER THERAPEUTICS
- Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck
- (2016) Robert L. Ferris et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
- (2016) Martin Reck et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
- (2016) Jesse M. Zaretsky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases
- (2016) Yingying Wang et al. RADIATION RESEARCH
- Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes
- (2016) Kelli A. Connolly et al. Oncotarget
- Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer
- (2016) Li Ren et al. Oncotarget
- Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer
- (2016) Eileen E. Parkes et al. JNCI-Journal of the National Cancer Institute
- A Lactate-Induced Response to Hypoxia
- (2015) Dong Chul Lee et al. CELL
- Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions
- (2015) A. Filatenkov et al. CLINICAL CANCER RESEARCH
- Complement Is a Central Mediator of Radiotherapy-Induced Tumor-Specific Immunity and Clinical Response
- (2015) Laura Surace et al. IMMUNITY
- Portrait of inflammatory response to ionizing radiation treatment
- (2015) Federica Di Maggio et al. Journal of Inflammation-London
- Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization
- (2015) Jason H. Stafford et al. NEURO-ONCOLOGY
- Pembrolizumab versus Ipilimumab in Advanced Melanoma
- (2015) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
- (2015) Olivier Demaria et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PD-1 Restrains Radiotherapy-Induced Abscopal Effect
- (2015) S. S. Park et al. Cancer Immunology Research
- Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy
- (2014) M I Koukourakis et al. BRITISH JOURNAL OF CANCER
- Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilization
- (2014) Young-Heon Kim et al. CANCER LETTERS
- Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade
- (2014) S. J. Dovedi et al. CANCER RESEARCH
- Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways
- (2014) Mirjam C. Boelens et al. CELL
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
- (2014) Liufu Deng et al. IMMUNITY
- Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells
- (2014) S. Matsumura et al. JOURNAL OF IMMUNOLOGY
- Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial
- (2014) Eugene D Kwon et al. LANCET ONCOLOGY
- Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
- (2014) Roy S. Herbst et al. NATURE
- Contextual regulation of pancreatic cancer stem cell phenotype and radioresistance by pancreatic stellate cells
- (2014) Osama Al-Assar et al. RADIOTHERAPY AND ONCOLOGY
- Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
- (2014) Twan van den Beucken et al. Nature Communications
- Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy
- (2013) Felix Klug et al. CANCER CELL
- CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
- (2013) J. Xu et al. CANCER RESEARCH
- Oncology Meets Immunology: The Cancer-Immunity Cycle
- (2013) Daniel S. Chen et al. IMMUNITY
- Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
- (2013) Paula D. Bos et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Combining Radiotherapy and Cancer Immunotherapy: A Paradigm Shift
- (2013) Silvia C. Formenti et al. JNCI-Journal of the National Cancer Institute
- Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats
- (2013) Shie-Chau Liu et al. NEURO-ONCOLOGY
- Skin Perfusion and Oxygenation Changes in Radiation Fibrosis
- (2013) Michael S. Chin et al. PLASTIC AND RECONSTRUCTIVE SURGERY
- Akt Promotes Irradiation-Induced Regulatory T-Cell Survival in Hepatocellular Carcinoma
- (2012) Chuan-Gang Li et al. AMERICAN JOURNAL OF THE MEDICAL SCIENCES
- Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche
- (2012) Jaclyn Sceneay et al. CANCER RESEARCH
- Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies
- (2012) I. Verbrugge et al. CANCER RESEARCH
- Suppressing T cell motility induced by anti–CTLA-4 monotherapy improves antitumor effects
- (2012) Maria Grazia Ruocco et al. JOURNAL OF CLINICAL INVESTIGATION
- Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
- (2012) Yu Sun et al. NATURE MEDICINE
- Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma
- (2012) Michael A. Postow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Protein Kinase B Promotes Radiation-Induced Regulatory T Cell Survival in Bladder Carcinoma
- (2012) M. Wang et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- Molecular Mechanisms of Treg-Mediated T Cell Suppression
- (2012) Angelika Schmidt et al. Frontiers in Immunology
- Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells
- (2012) Katrin Manda et al. Frontiers in Oncology
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
- (2011) Weibo Luo et al. CELL
- IL-13 Induces Connective Tissue Growth Factor in Rat Hepatic Stellate Cells via TGF- -Independent Smad Signaling
- (2011) Y. Liu et al. JOURNAL OF IMMUNOLOGY
- Inhibition of JAK2 Signaling by TG101209 Enhances Radiotherapy in Lung Cancer Models
- (2011) Yunguang Sun et al. Journal of Thoracic Oncology
- Tumor hypoxia is an important mechanism of radioresistance in hypofractionated radiotherapy and must be considered in the treatment planning process
- (2011) David J. Carlson et al. MEDICAL PHYSICS
- γ-Radiation Promotes Immunological Recognition of Cancer Cells through Increased Expression of Cancer-Testis Antigens In Vitro and In Vivo
- (2011) Anu Sharma et al. PLoS One
- Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress
- (2011) M. Bauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Low-dose radiation augments vasculogenesis signaling through HIF-1-dependent and -independent SDF-1 induction
- (2010) O. Z. Lerman et al. BLOOD
- Macrophage Expression of Hypoxia-Inducible Factor-1 Suppresses T-Cell Function and Promotes Tumor Progression
- (2010) A. L. Doedens et al. CANCER RESEARCH
- Recruitment of Myeloid but not Endothelial Precursor Cells Facilitates Tumor Regrowth after Local Irradiation
- (2010) S. V. Kozin et al. CANCER RESEARCH
- Radiation Enhances Regulatory T Cell Representation
- (2010) Evelyn L. Kachikwu et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
- (2010) Mitomu Kioi et al. JOURNAL OF CLINICAL INVESTIGATION
- HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
- (2010) Cesar A. Corzo et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Resistance of CD45RA- T Cells to Apoptosis and Functional Impairment, and Activation of Tumor-Antigen Specific T Cells during Radiation Therapy of Prostate Cancer
- (2010) Z. Tabi et al. JOURNAL OF IMMUNOLOGY
- Autocrine TGF- and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
- (2010) Y. Kojima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Radiation-induced cell death mechanisms
- (2010) David Eriksson et al. TUMOR BIOLOGY
- Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
- (2009) Y. Lee et al. BLOOD
- Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody
- (2009) M. Z. Dewan et al. CLINICAL CANCER RESEARCH
- Hypoxia and Radiation Therapy: Past History, Ongoing Research, and Future Promise
- (2009) Sara Rockwell et al. CURRENT MOLECULAR MEDICINE
- Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
- (2009) François Ghiringhelli et al. NATURE MEDICINE
- 1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts
- (2008) C. C. Park et al. CANCER RESEARCH
- T-Cell Responses to Survivin in Cancer Patients Undergoing Radiation Therapy
- (2008) D. Schaue et al. CLINICAL CANCER RESEARCH
- Single-Dose and Fractionated Irradiation Promote Initiation and Progression of Atherosclerosis and Induce an Inflammatory Plaque Phenotype in ApoE−/− Mice
- (2008) Saske Hoving et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
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