Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion

Tumor-derived exosomes antagonize innate antiviral immunity

(2018) Liang Gao et al.   NATURE IMMUNOLOGY

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

(2018) Kimitoshi Kimura et al.   Nature Communications

Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

(2018) Xu Zhang et al.   Molecular Cancer

Damage-Associated molecular pattern markers HMGB1 and cell-Free fetal telomere fragments in oxidative-Stressed amnion epithelial cell-Derived exosomes

(2017) Samantha Sheller-Miller et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells

(2016) Y Deng et al.   ONCOGENE

CD19+IL-10+ regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4+ T cells to CD4+Foxp3+ regulatory T cells

(2016) Xi Zhou et al.   ORAL ONCOLOGY

PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression

(2016) X. Xiao et al.   Cancer Discovery

TIM-1 Signaling Is Required for Maintenance and Induction of Regulatory B Cells

(2015) M. Y. Yeung et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Information transfer by exosomes: A new frontier in hematologic malignancies

(2015) Michael Boyiadzis et al.   BLOOD REVIEWS

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

The expanding family of regulatory B cells

(2015) Claudia Mauri et al.   INTERNATIONAL IMMUNOLOGY

Tim-1 Is Essential for Induction and Maintenance of IL-10 in Regulatory B Cells and Their Regulation of Tissue Inflammation

(2015) Sheng Xiao et al.   JOURNAL OF IMMUNOLOGY

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

(2015) Y. Pylayeva-Gupta et al.   Cancer Discovery

TIMgenes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

(2015) Gordon J. Freeman et al.   IMMUNOLOGICAL REVIEWS

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

(2014) Nesrine I. Affara et al.   CANCER CELL

Enhanced frequency and potential mechanism of B regulatory cells in patients with lung cancer

(2014) Jiebai Zhou et al.   Journal of Translational Medicine

Molecular Control of Steady-State Dendritic Cell Maturation and Immune Homeostasis

(2013) Gianna Elena Hammer et al.   Annual Review of Immunology

HMGB1 in Cancer: Good, Bad, or Both?

(2013) R. Kang et al.   CLINICAL CANCER RESEARCH

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion

(2012) Yu Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases

(2012) Wei Yan et al.   HEPATOLOGY

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice

(2011) Qing Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

(2011) Douglas D. Taylor et al.   Seminars in Immunopathology

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

(2008) Takuya Ueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunostimulatory Tim-1–specific antibody deprograms Tregs and prevents transplant tolerance in mice

(2008) Nicolas Degauque et al.   JOURNAL OF CLINICAL INVESTIGATION