IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

Progress and challenges of predictive biomarkers of anti PD-1/PD-L1 immunotherapy: A systematic review

(2018) Feifei Teng et al.   CANCER LETTERS

Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment

(2018) Hirotake Tsukamoto et al.   CANCER RESEARCH

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Safety of combining radiotherapy with immune-checkpoint inhibition

(2018) William L. Hwang et al.   Nature Reviews Clinical Oncology

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations

(2018) Ioannis Zerdes et al.   ONCOGENE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

CCL15 recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma

(2018) Long-Zi Liu et al.   HEPATOLOGY

IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors

(2018) Sahil Gupta et al.   OncoImmunology

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Efficacy and Safety of Pembrolizumab for Heavily Pretreated Patients With Advanced, Metastatic Adenocarcinoma or Squamous Cell Carcinoma of the Esophagus

(2018) Manish A. Shah et al.   JAMA Oncology

IL-6 roles – Molecular pathway and clinical implication in pancreatic cancer – A systemic review

(2017) Vlad-Vasile Pop et al.   IMMUNOLOGY LETTERS

MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway

(2017) L Deng et al.   ONCOGENE

Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke’s cell morphology

(2017) Filip Garbicz et al.   Pituitary

Identification of a sixteen-microRNA signature as prognostic biomarker for stage II and III colon cancer

(2017) Havjin Jacob et al.   Oncotarget

Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma

(2017) Tomohiro Fujiwara et al.   Oncotarget

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer

(2016) Tae-Hwe Heo et al.   Oncotarget

Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish

(2016) Ye Zhao et al.   Scientific Reports

Identification of reference genes for circulating microRNA analysis in colorectal cancer

(2016) Yanqin Niu et al.   Scientific Reports

Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma

(2015) Yang Wen et al.   INTERNATIONAL JOURNAL OF CANCER

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway

(2015) Kim C. Ohaegbulam et al.   TRENDS IN MOLECULAR MEDICINE

PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma

(2015) Jiajie Hou et al.   Journal of Molecular Cell Biology

Correction: Circulating miR-25-3p and miR-451a May Be Potential Biomarkers for the Diagnosis of Papillary Thyroid Carcinoma

(2015) Min Li et al.   PLoS One

Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-κB Signaling and Protects against Endotoxin Shock

(2014) Yanbo Zhang et al.   IMMUNITY

Inactivation of MYC reverses tumorigenesis

(2014) Y. Li et al.   JOURNAL OF INTERNAL MEDICINE

A Genetic Variant in the Promoter Region of miR-106b-25 Cluster Predict Clinical Outcome of HBV-Related Hepatocellular Carcinoma in Chinese

(2014) Fuzhen Qi et al.   PLoS One

A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma

(2014) J Tang et al.   Cell Death & Disease

PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy

(2013) Yi-Teng Huang et al.   Journal of Translational Medicine

Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3

(2012) Jiajie Hou et al.   HEPATOLOGY

A Genetic Variant in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma

(2012) Yao Liu et al.   PLoS One

TSA Suppresses miR-106b-93-25 Cluster Expression through Downregulation of MYC and Inhibits Proliferation and Induces Apoptosis in Human EMC

(2012) Zhi-Ning Zhao et al.   PLoS One

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

(2011) O. M. Pello et al.   BLOOD

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

(2010) Kavya Rakhra et al.   CANCER CELL

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice

(2010) Y Gao et al.   ONCOGENE