Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells

Lighting the way to personalized mRNA immune cell therapies

(2022) Ann E. Metzloff et al.   Science Advances

In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

(2022) Fang-Yi Su et al.   Science Advances

Nanomaterials for T-cell cancer immunotherapy

(2021) Ningqiang Gong et al.   Nature Nanotechnology

mRNA vaccine for cancer immunotherapy

(2021) Lei Miao et al.   Molecular Cancer

Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines

(2021) Kelsey L. Swingle et al.   TRENDS IN MOLECULAR MEDICINE

Delivery technologies for T cell gene editing: Applications in cancer immunotherapy

(2021) Ella S. Atsavapranee et al.   EBioMedicine

All‐In‐One Dendrimer‐Based Lipid Nanoparticles Enable Precise HDR‐Mediated Gene Editing In Vivo

(2021) Lukas Farbiak et al.   ADVANCED MATERIALS

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

(2021) Sarah J. Shepherd et al.   NANO LETTERS

Unravelling cytosolic delivery of cell penetrating peptides with a quantitative endosomal escape assay

(2021) Serena L. Y. Teo et al.   Nature Communications

Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery

(2021) Kelsey L. Swingle et al.   JOURNAL OF CONTROLLED RELEASE

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery

(2020) Jeonghwan Kim et al.   Cellular and Molecular Bioengineering

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

(2020) Zubao Gan et al.   Bioengineering & Translational Medicine

In Vitro-Transcribed mRNA Chimeric Antigen Receptor T Cell (IVT mRNA CAR T) Therapy in Hematologic and Solid Tumor Management: A Preclinical Update

(2020) Thangavelu Soundara Rajan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in Lipid Nanoparticles for mRNA-Based Cancer Immunotherapy

(2020) Maria L. Guevara et al.   Frontiers in Chemistry

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy

(2019) Jessica B. Foster et al.   MOLECULAR THERAPY

NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

(2019) Suzanne R. Pfeffer   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA delivery through nanoparticles

(2019) Sharon Wei Ling Lee et al.   JOURNAL OF CONTROLLED RELEASE

Challenges in assessing solid tumor responses to immunotherapy

(2019) Louis F. Chai et al.   CANCER GENE THERAPY

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Correlation Coefficients

(2018) Patrick Schober et al.   ANESTHESIA AND ANALGESIA

A guide to manufacturing CAR T cell therapies

(2018) Philipp Vormittag et al.   CURRENT OPINION IN BIOTECHNOLOGY

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA

(2018) Rebecca L. Ball et al.   NANO LETTERS

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

Quantitative analysis of receptor-mediated uptake and pro-apoptotic activity of mistletoe lectin-1 by high content imaging

(2018) N. Beztsinna et al.   Scientific Reports

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA

(2017) Siddharth Patel et al.   NANO LETTERS

Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers

(2017) Masatoshi Maeki et al.   PLoS One

Modulating Cholesterol Homeostasis to Build a Better T Cell

(2016) Yoko Kidani et al.   Cell Metabolism

The role of cholesterol in membrane fusion

(2016) Sung-Tae Yang et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

Lipid nanoparticles for targeted siRNA delivery – going from bench to bedside

(2016) Victor Kotelianski et al.   International Journal of Nanomedicine

The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA

(2016) Haitang Wang et al.   MOLECULAR THERAPY

In vitro and ex vivo strategies for intracellular delivery

(2016) Martin P. Stewart et al.   NATURE

Clinical manufacturing of CAR T cells: foundation of a promising therapy

(2016) Xiuyan Wang et al.   Molecular Therapy-Oncolytics

Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics

(2015) Cornelia Lorenzer et al.   JOURNAL OF CONTROLLED RELEASE

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Highly Stable and Sensitive Fluorescent Probes (LysoProbes) for Lysosomal Labeling and Tracking

(2015) Nazmiye B. Yapici et al.   Scientific Reports

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Rab11 regulates exocytosis of recycling vesicles at the plasma membrane

(2012) Senye Takahashi et al.   JOURNAL OF CELL SCIENCE

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An mRNA vaccine for influenza

(2012) Sook-San Wong et al.   NATURE BIOTECHNOLOGY

Oxysterols are allosteric activators of the oncoprotein Smoothened

(2012) Sigrid Nachtergaele et al.   Nature Chemical Biology

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

(2012) Mi Kyung Yu et al.   Theranostics

Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

(2011) David M. Barrett et al.   HUMAN GENE THERAPY

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

(2008) R. E. Infante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA