Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
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Title
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
Authors
Keywords
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Journal
NANO LETTERS
Volume 21, Issue 13, Pages 5671-5680
Publisher
American Chemical Society (ACS)
Online
2021-07-01
DOI
10.1021/acs.nanolett.1c01353
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Note: Only part of the references are listed.- Clinical approval of nanotechnology-based SARS-CoV-2 mRNA vaccines: impact on translational nanomedicine
- (2021) Lara Milane et al. Drug Delivery and Translational Research
- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines
- (2021) Kelsey L. Swingle et al. TRENDS IN MOLECULAR MEDICINE
- Microfluidic formulation of nanoparticles for biomedical applications
- (2021) Sarah J. Shepherd et al. BIOMATERIALS
- Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
- (2020) Margaret M. Billingsley et al. NANO LETTERS
- Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes
- (2020) Cameron Webb et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Lipid nanoparticle technology for therapeutic gene regulation in the liver
- (2020) Dominik Witzigmann et al. ADVANCED DRUG DELIVERY REVIEWS
- Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
- (2020) Alexandre J. Debacker et al. MOLECULAR THERAPY
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics
- (2020) Carla B. Roces et al. Pharmaceutics
- Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand
- (2020) Zoltán Kis et al. Vaccines
- The current state and future directions of RNAi-based therapeutics
- (2019) Ryan L. Setten et al. NATURE REVIEWS DRUG DISCOVERY
- Lipid nanoparticles for delivery of messenger RNA to the back of the eye
- (2019) Siddharth Patel et al. JOURNAL OF CONTROLLED RELEASE
- Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide
- (2019) Dominik Witzigmann et al. eLife
- Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications
- (2019) Anna Angela Barba et al. Pharmaceutics
- A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
- (2019) Guojun Chen et al. Nature Nanotechnology
- Robust Microfabrication of Highly Parallelized Three-Dimensional Microfluidics on Silicon
- (2019) Sagar Yadavali et al. Scientific Reports
- Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening
- (2019) Pedro P.G. Guimaraes et al. JOURNAL OF CONTROLLED RELEASE
- The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
- (2019) Akin Akinc et al. Nature Nanotechnology
- Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA
- (2018) Rebecca L. Ball et al. NANO LETTERS
- Silicon and glass very large scale microfluidic droplet integration for terascale generation of polymer microparticles
- (2018) Sagar Yadavali et al. Nature Communications
- Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility
- (2018) Jayesh A. Kulkarni et al. Nucleic Acid Therapeutics
- Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems
- (2017) S Guan et al. GENE THERAPY
- Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices
- (2017) Michael J. Toth et al. LAB ON A CHIP
- Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles
- (2017) R. Krzysztoń et al. Nanoscale
- Clogging of microfluidic systems
- (2017) Emilie Dressaire et al. Soft Matter
- Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization
- (2016) Rebecca Ball et al. International Journal of Nanomedicine
- Microfluidics: a transformational tool for nanomedicine development and production
- (2016) Shyam Garg et al. JOURNAL OF DRUG TARGETING
- Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
- (2016) Matthias A. Oberli et al. NANO LETTERS
- Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
- (2016) Hao Yin et al. NATURE BIOTECHNOLOGY
- Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production
- (2016) Chia-Wen Tsao Micromachines
- Kilo-scale droplet generation in three-dimensional monolithic elastomer device (3D MED)
- (2015) Heon-Ho Jeong et al. LAB ON A CHIP
- Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
- (2015) Kevin J. Kauffman et al. NANO LETTERS
- A facile route to the synthesis of monodisperse nanoscale liposomes using 3D microfluidic hydrodynamic focusing in a concentric capillary array
- (2014) Renee R. Hood et al. LAB ON A CHIP
- Stabilization of Ostwald Ripening in Low Molecular Weight Amino Lipid Nanoparticles for Systemic Delivery of siRNA Therapeutics
- (2014) Marian E. Gindy et al. MOLECULAR PHARMACEUTICS
- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
- (2014) Kathryn A. Whitehead et al. Nature Communications
- Hybrid soft-lithography/laser machined microchips for the parallel generation of droplets
- (2013) M. Muluneh et al. LAB ON A CHIP
- Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study
- (2013) Jong-Min Lim et al. Nanomedicine-Nanotechnology Biology and Medicine
- RNA-Based Therapeutics: Current Progress and Future Prospects
- (2012) John C. Burnett et al. CHEMISTRY & BIOLOGY
- Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic
- (2012) Anu Puri et al. CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
- Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core
- (2012) Alex K. K. Leung et al. Journal of Physical Chemistry C
- Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation
- (2012) Delai Chen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- High throughput production of single core double emulsions in a parallelized microfluidic device
- (2012) Mark B. Romanowsky et al. LAB ON A CHIP
- Microfluidic technologies for accelerating the clinical translation of nanoparticles
- (2012) Pedro M. Valencia et al. Nature Nanotechnology
- Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
- (2012) Nathan M Belliveau et al. Molecular Therapy-Nucleic Acids
- Current prospects for RNA interference-based therapies
- (2011) Beverly L. Davidson et al. NATURE REVIEWS GENETICS
- Microfluidic Mixing and the Formation of Nanoscale Lipid Vesicles
- (2010) Andreas Jahn et al. ACS Nano
- Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles
- (2010) Randy Crawford et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Rational design of cationic lipids for siRNA delivery
- (2010) Sean C Semple et al. NATURE BIOTECHNOLOGY
- Lipid-like materials for low-dose, in vivo gene silencing
- (2010) K. T. Love et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipid-based nanotherapeutics for siRNA delivery
- (2009) A. Schroeder et al. JOURNAL OF INTERNAL MEDICINE
- Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment
- (2009) Marc T Abrams et al. MOLECULAR THERAPY
- A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
- (2008) Akin Akinc et al. NATURE BIOTECHNOLOGY
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