Editorial Material
Oncology
Pierre L. Levy, Alena Gros
Summary: In this study, single-cell multi-omics technology was used to identify phenotypic and transcriptomic signatures of neoantigen-reactive clonotypes in lung cancer resident lymphocytes. These findings have the potential to accelerate the selection of neoantigen-specific T cell receptors (TCRs) for individualized T cell therapies.
Editorial Material
Pharmacology & Pharmacy
Christina C. Kuismi, Behnam Nabet
Summary: NIR light can be used for precise release of PROTAC and protein degradation in mouse tumors, achieving tumor-specific protein loss.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Review
Multidisciplinary Sciences
Darrell J. Irvine, Marcela V. Maus, David J. Mooney, Wilson W. Wong
Summary: Immune cell therapy is a promising approach to treating diseases, especially cancer, by engineering immune cells to recognize and respond to specific conditions. This therapy has already been approved for clinical use and continues to be developed and tested in various applications.
Review
Medicine, General & Internal
Xing Huang, Gang Zhang, Tian Yu Tang, Xiang Gao, Ting Bo Liang
Summary: Pancreatic cancer vaccines offer multifaceted advantages, with personalized mRNA vaccines showing promising potential as a cutting-edge option for precise treatment. Further research and development in this area is warranted.
MILITARY MEDICAL RESEARCH
(2022)
Review
Cell & Tissue Engineering
Margit Rosner, Markus Hengstschlager
Summary: Clinicians and patients hope that stem cell-based therapies will be effective remedies for various diseases and injuries. However, the use of pluripotent stem cells is still hindered by their potential to cause immune reactions and tumor formation. In addition, stem cells can influence the behavior of nearby cells, which can have both beneficial and detrimental effects on therapeutic outcomes.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Carla Tortorella, Alessandra Aiello, Claudio Gasperini, Chiara Agrati, Concetta Castilletti, Serena Ruggieri, Silvia Meschi, Giulia Matusali, Francesca Colavita, Chiara Farroni, Gilda Cuzzi, Eleonora Cimini, Eleonora Tartaglia, Valentina Vanini, Luca Prosperini, Shalom Haggiag, Simona Galgani, Maria Esmeralda Quartuccio, Andrea Salmi, Federica Repele, Anna Maria Gerarda Altera, Flavia Cristofanelli, Alessandra D'Abramo, Nazario Bevilacqua, Angela Corpolongo, Vincenzo Puro, Francesco Vaia, Maria Rosaria Capobianchi, Giuseppe Ippolito, Emanuele Nicastri, Delia Goletti
Summary: This study evaluated the immune-specific response after full SARS-CoV-2 vaccination in patients with multiple sclerosis (MS) treated with different disease-modifying drugs. The results showed that mRNA vaccines induced both humoral and cell-mediated specific immune responses against viral spike proteins in the majority of patients with MS. These findings have important implications for promoting vaccination in all MS patients.
Editorial Material
Clinical Neurology
Mark J. Edwards
Summary: Patients with medically unexplained or functional symptoms, often avoided by health professionals, may hold the key to a more successful, meaningful, and just system of medical practice. They prompt us to consider the human and participatory aspect of illness, which is often neglected in medical training and practice. There is room for improvement in addressing this aspect in healthcare.
Article
Endocrinology & Metabolism
Peter S. Linsley, Carla J. Greenbaum, Gerald T. Nepom
Summary: The goal of personalized medicine is to match the right drugs to the right patients at the right time. However, for complex diseases like type 1 diabetes, personalized therapy should consider factors such as treatment timing, patient stratification, pharmacodynamic biomarkers, and efficacy biomarkers. Research in personalized medicine for type 1 diabetes is providing insights for achieving personalized therapies for other complex diseases.
Review
Chemistry, Multidisciplinary
Monika Nehra, U. T. Uthappa, Virendra Kumar, Rajesh Kumar, Chandra Dixit, Neeraj Dilbaghi, Yogendra Kumar Mishra, Sandeep Kumar, Ajeet Kaushik
Summary: This review explores the limitations of current brain cancer treatment and the potential benefits of using nanobiotechnology, such as nanocarriers and nano-assisted therapies, to improve efficacy and minimize adverse effects. The focus is on personalized approaches based on unique genetic characteristics of patients and their disease profiles, highlighting the emerging opportunities in nanotechnology for advancing brain cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Editorial Material
Medicine, General & Internal
Sham Mailankody, Ola Landgren
Summary: BCMA has been recognized as a prognostic marker in multiple myeloma for over two decades, and is now a major target for various treatments including CAR T cells, antibody drug conjugates, and bispecific antibodies. The rapid translation from preclinical studies to FDA-approved treatments demonstrates significant success in the field.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Immunology
Alice Mariottini, Paolo A. Muraro, Jan D. Luenemann
Summary: Development of disease-modifying therapies for multiple sclerosis, such as monoclonal antibody-based cell depletion therapies, has been successful in eliminating pathological immune cell components and promoting the reconstitution of a healthy immune system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Roberto Limongello, Andrea Marra, Antonella Mancusi, Samanta Bonato, Eni Hoxha, Loredana Ruggeri, Susanta Hui, Andrea Velardi, Antonio Pierini
Summary: Adverse genetic risk acute myeloid leukemia (AML) poses a significant treatment challenge with poor outcomes, necessitating novel therapeutic approaches. While allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the curative option, high relapse rates and dismal outcomes prompt the exploration of new transplant strategies. Recent research has shown that haploidentical allo-HSCT combined with T cell adoptive immunotherapy can overcome chemoresistance and improve survival in AML patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Jianpei Hu, Zhongze Yuan, Yifen Jiang, Zengnan Mo
Summary: This study identified five tumor antigens associated with PRCC and disclosed two immune subtypes with distinct characteristics. These findings provide insights for the design of anti-PRCC mRNA vaccines and the selection of suitable patients to be vaccinated.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Federica Dominelli, Maria Antonella Zingaropoli, Matteo Tartaglia, Eeva Tortellini, Mariasilvia Guardiani, Valentina Perri, Patrizia Pasculli, Federica Ciccone, Leonardo Malimpensa, Viola Baione, Anna Napoli, Aurelia Gaeta, Miriam Lichtner, Antonella Conte, Claudio Maria Mastroianni, Maria Rosa Ciardi
Summary: The study evaluated the humoral and specific T-cell response in people with MS under DMTs before and after vaccination. The results showed that DMTs may influence the immune response to vaccination in MS patients. The understanding of T-cell quality dynamic is important for determining the best vaccination strategy for MS patients under different DMTs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Jialing Zhang, Zhanxu Chen, An Wang, Zhenzhang Li, Wei Wan
Summary: This article proposes an intelligent control system for personalized lighting in home environments, using facial recognition and machine learning algorithms to automatically adjust the lighting environment and provide a personalized lighting experience, contributing to energy conservation and environmental sustainability.
Article
Pharmacology & Pharmacy
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Summary: Evasion of apoptosis is a characteristic of cancer, and overexpression of Bcl-2 is a contributing factor. Therapeutic targeting of Bcl-2 has shown efficacy in the clinic and is being extensively tested in combination with chemotherapy. Therefore, developing co-delivery systems for Bcl-2 targeting agents and chemotherapeutics, such as LNPs, holds promise for combination cancer therapies.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Cardiac & Cardiovascular Systems
Junchao Xu, Na Yan, Chunling Wang, Chao Gao, Xuexiang Han, Chengzhi Yang, Jiaqi Xu, Kun Wang, Michael J. J. Mitchell, Yinlong Zhang, Guangjun Nie
Summary: A study found that platelet-mimicking nanosponges can efficiently reverse the antiplatelet effect of drugs, reducing the risk of bleeding during surgery without causing thrombosis. This research provides a promising strategy for managing bleeding complications caused by antiplatelet therapy.
CIRCULATION RESEARCH
(2023)
Review
Biochemical Research Methods
Ghazal Bashiri, Marshall S. Padilla, Kelsey L. Swingle, Sarah J. Shepherd, Michael J. Mitchell, Karin Wang
Summary: Nanoparticle (NP)-based therapeutics have revolutionized translational medicine, but the mechanisms by which NPs interact and evolve in biological environments remain poorly understood. When exposed to physiological fluids, NPs are encased in a protein corona (PC) that can profoundly impact their behavior. The conformation and orientation of proteins in vivo can be influenced by biological factors and interactions with NPs, potentially altering their function. This review explores the effects of PC on protein conformation and discusses how this knowledge can be leveraged for therapeutic purposes.
Article
Nanoscience & Nanotechnology
Rebecca M. Haley, Alexander Chan, Margaret M. Billingsley, Ningqiang Gong, Marshall S. Padilla, Emily H. Kim, Hejia Wang, Dingzi Yin, Kirk J. Wangensteen, Andrew Tsourkas, Michael J. Mitchell
Summary: This study demonstrates the successful delivery of DARPin protein K27-D30 to the cytosol of liver cancer cells using a lipid nanoparticle platform, inhibiting RAS-driven tumor growth and highlighting the potential of K27 as a new cancer therapeutic.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Michael J. Mitchell, Kelsey L. Swingle, Hannah C. Safford, Hannah C. Geisler, Alex G. Hamilton, Ajay S. Thatte, Margaret M. Billingsley, Ryann A. Joseph, Kaitlin Mrksich, Marshall S. Padilla, Aditi A. Ghalsasi, Mohamad-Gabriel Alameh, Drew Weissman
Summary: This study developed ionizable lipid nanoparticles (LNPs) for mRNA delivery to the placenta to regulate placental vasodilation. By designing a combination of ionizable lipids, a lead LNP was identified that can deliver mRNA to trophoblasts, endothelial cells, and immune cells in the placenta. Injection of LNPs encapsulated with VEGF-A mRNA resulted in placental vasodilation, demonstrating the potential of mRNA LNPs for protein replacement therapy to treat placental disorders during pregnancy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Editorial Material
Chemistry, Physical
Ningqiang Gong, Alex G. G. Hamilton, Michael J. J. Mitchell
Summary: A curvature-sensing peptide is utilized to disrupt exosomes, leading to improved cancer immunotherapy.
Editorial Material
Nanoscience & Nanotechnology
Ningqiang Gong, Michael. J. J. Mitchell
Summary: Drug delivery to the bone marrow is not efficient enough. Hitchhiking on bone marrow homing neutrophils provides a solution.
NATURE NANOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Hannah C. Geisler, Hannah C. Safford, Michael J. Mitchell
Summary: The placenta, a temporary organ during pregnancy, plays a vital role in regulating exchange between maternal and fetal circulation. Placental disorders such as preeclampsia, fetal growth restriction, placenta accreta spectrum, and gestational trophoblastic disease arise from abnormal placental development and can lead to severe complications. Nanomedicine offers potential solutions to these disorders by selectively delivering therapeutics to the placenta while protecting the fetus. This review discusses nanomedicine strategies to diagnose and treat placental disorders and highlights novel disease targets for the rational design of precision nanocarriers.
Article
Biochemistry & Molecular Biology
Alex G. Hamilton, Kelsey L. Swingle, Michael J. Mitchell
Summary: The use of therapeutic nucleic acids has been challenging due to the barriers in their delivery. However, in the past two decades, the development of ionizable lipid nanoparticles as carriers for nucleic acid delivery has overcome these obstacles and found success in clinical applications.
Editorial Material
Engineering, Biomedical
Ningqiang Gong, Alex G. Hamilton, Michael J. Mitchell
Summary: Confining the Zika virus within a self-adjuvanting hydrogel that forms a subcutaneous inflammatory niche stimulates strong immune responses in mice without inducing infection.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Cell & Tissue Engineering
Christian G. Figueroa-Espada, Pedro P. G. Guimaraes, Rachel S. Riley, Lulu Xue, Karin Wang, Michael J. Mitchell
Summary: Our study utilized a lipid-polymer nanoparticle delivery system for RNAi therapy to effectively downregulate ES and CyPA expression and inhibit the colonization and dissemination of MM cells in the bone marrow microenvironment. In vivo delivery of these nanoparticles extended survival in a xenograft mouse model of MM. This combination siRNA therapy presents a potential shift in the treatment of MM and other cancers that colonize the bone marrow.
CELLULAR AND MOLECULAR BIOENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Ajay S. Thatte, Alex G. Hamilton, Benjamin E. Nachod, Alvin J. Mukalel, Margaret M. Billingsley, Rohan Palanki, Kelsey L. Swingle, Michael J. Mitchell
Summary: In this study, an ionizable lipid nanoparticle platform was developed to deliver Foxp3 mRNA to CD4(+) T cells, effectively engineering them into immunosuppressive cells. The results highlight the potential of this platform for engineering immunosuppressive T cells.
Article
Chemistry, Physical
Ningqiang Gong, Xuexiang Han, Lulu Xue, Rakan El-Mayta, Ann E. Metzloff, Margaret M. Billingsley, Alex G. Hamilton, Michael J. Mitchell
Summary: In situ PEGylation of CAR T cells provides a materials-based strategy for safer cellular immunotherapy by blocking cell-to-cell interactions and decreasing toxic cytokine secretion. It also allows for controlled tumor killing and immune response stimulation, mitigating cytokine release syndrome and reducing neurotoxicity.
Article
Chemistry, Multidisciplinary
Hannah C. Safford, Kelsey L. Swingle, Hannah C. Geisler, Alex G. Hamilton, Ajay S. Thatte, Aditi A. Ghalsasi, Margaret M. Billingsley, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Summary: During healthy pregnancy, the placenta allows for exchange of nutrients and oxygen between the mother and fetus. Placental dysregulation can lead to pregnancy disorders, but lipid nanoparticle-mediated mRNA delivery shows promise in treating these disorders.
